Fibroepithelial Lesions of the Breast: Update on Molecular Profile With Focus on Pediatric Population

Abstract

Context.— This review article derives from the breast pathology lecture at the Eighth Princeton Integrated Pathology Symposium (PIPS VIII). Objective.— To provide a literature review and update on fibroepithelial lesions of the breast with molecular findings and findings regarding the pediatric population. Data Sources.— The sources include extensive literature review, personal research, and experience. Conclusions.— Given significant differences in prognosis and management of fibroepithelial lesions, we aim to provide readers with pertinent definitions, pathomorphology, molecular findings, and management for each diagnosis, with insights on the pediatric population.

The Genetic Landscape of Fibroepithelial Lesions of the Breast

“…Advances in molecular pathology in recent years have provided new insights into the genetic landscape of various tumors, thereby improving diagnostic accuracy and helping to guide treatment decisions. The molecular pathogenesis of FELs of the breast is still not fully understood, but the characterization of the genetic landscape of these lesions has been pursued with the goal of creating a more objective and clinically relevant classification scheme for FELs of the breast 10,11 …”

“…The molecular pathogenesis of FELs of the breast is still not fully understood, but the characterization of the genetic landscape of these lesions has been pursued with the goal of creating a more objective and clinically relevant classification scheme for FELs of the breast. 10,11 In this review, we summarize the challenges in the diagnosis of FELs of the breast, most notably their overlapping histology and limitations of current ancillary techniques in stratifying them into biologically relevant groups. We highlight the most recent molecular and genetic findings which inform their pathogenesis and, if properly applied, may assist in the diagnostic evaluation of this morphologic spectrum of breast tumors.…”