Fibromatosis of the Breast or Carcinoma?

Yiangou, C; Fadl, H.; Sinnett, H. D.; Shousha, S

doi:10.1177/014107689608901111

Cited by 16 publications

(16 citation statements)

References 10 publications

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“…Clinically, fibromatosis unusually presents as a solitary, palpable, mobile, firm, and typically painless mass [6] , [9] . Some patients may report skin and nipple retraction [4] , [6] , [9] . Fibromatosis of the breast is often unilateral, but up to 4% of patients may present with bilateral fibromatosis [6] .…”

Section: Discussionmentioning

confidence: 99%

“…Definitive diagnosis is based on histology, which shows lesions composed of bundles of long sweeping and intersecting spindle cells with varying amounts of collagen deposition and low mitotic rate [2] , [3] , [4] , [6] . The histologic differential diagnosis includes benign and malignant entities such as low-grade fibrosarcoma which usually shows increased cellularity with more pronounced cytologic pleomorphism and atypia and increased mitotic activity; metaplastic, or spindle cell carcinoma which usually has areas of cohesive atypical epithelium and immunohistochemical cytokeratin staining; nodular fasciitis which usually presents as a tender, rapidly growing subcutaneous mass and histologically contains abundant inflammatory cells dispersed in the loose myxoid stroma; phyllodes tumor which usually has epithelial-lined clefts and CD34 positivity; and scar and biopsy-site reaction [1] , [2] , [4] , [6] , [9] . Fibromatosis of the breast typically exhibits nuclear positivity for beta-catenin and lacks estrogen receptor and progesterone receptor positivity [6] .…”

Section: Discussionmentioning

confidence: 99%

“…Fibromatosis of the breast can occur anywhere in the breast and has been reported to arise primarily within the breast tissue or from the underlying pectoralis major muscle [4] . An association with Gardner syndrome, surgical trauma, or breast augmentation with saline or silicone breast implants has been reported [1] , [2] , [4] , [6] , [9] . Clonality of desmoid-type fibromatosis has been described [14] .…”

Section: Discussionmentioning

confidence: 99%

“…Fibromatosis of the breast usually recurs within 3 years of excision and requires radical excision [3] , [4] , [6] , [22] . The size, atypia, cellularity, and number of mitoses cannot predict likelihood of recurrence [9] .…”

Section: Discussionmentioning

confidence: 99%

“…Fibromatosis of the breast is more common in young and fertile women, but occurrences in men have been reported [1] , [6] . Patients range in age from 13 to 83 years old, with a reported mean age at diagnosis between 37 and 50.3 years [6] , [9] .…”

Section: Introductionmentioning

confidence: 99%

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Radiologic images of an aggressive implant-associated fibromatosis of the breast and chest wall: case report and review of the literature

Alanis

Roth

Lerman³

et al. 2017

Radiology Case Reports

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Fibromatosis of the breast is a rare benign disease compromising <0.2% of all primary breast tumors. Although the chest wall is a common location, occurrences of implant-associated fibromatosis of the breast are extremely rare; only 33 cases have been reported. We present a case of a 42-year-old female who underwent breast augmentation with silicone breast implants, and 2 years later developed an aggressive implant-associated fibromatosis of the breast and chest wall. On imaging studies, the tumor mimicked breast carcinoma, and despite chemotherapy, the fibromatosis rapidly enlarged and was locally invasive requiring wide surgical excision. Unlike previously reported imaging findings, magnetic resonance imaging revealed an oval circumscribed mass with fringe-like internal architecture. We provide a review of the literature and discuss the imaging features of implant-associated fibromatosis of the breast.

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