Fibromyalgia of Women Who Gave Birth and Pregnancy Outcome Parameters

Koné, Maïmouna Coura; Kambiré, Nabé Alphonse; Kouakou, Kouassi Joseph; Ahoua, Yapi

doi:10.4236/ojepi.2022.121001

Cited by 1 publication

(2 citation statements)

References 13 publications

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“…The literature on the interaction between FM and pregnancy is limited, though the available studies do provide evidence that justifies further exploration of this relationship. Two studies have reported that around 50% of their study population experienced FM symptoms after childbirth, and this rate was higher in those who had delivered by cesarians vs. vaginal births [45,46]. However, these studies did not confirm whether any of these patients had pre-existing FM.…”

Section: Interactions Between Fm and Pregnancymentioning

confidence: 94%

“…However, these studies did not confirm whether any of these patients had pre-existing FM. Other studies demonstrated that pregnant females with pre-existing FM experienced an aggravation of symptoms throughout pregnancy, and particularly in the third trimester, the symptoms were at their worst [46][47][48]. There were also reported changes to symptoms in the postnatal period, while hormonal changes connected with abortion, use of hormonal contraceptives, and breastfeeding did not modulate FM symptom severity [45,49,50].…”

Section: Interactions Between Fm and Pregnancymentioning

confidence: 96%

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Fibromyalgia in Pregnancy: Neuro-Endocrine Fluctuations Provide Insight into Pathophysiology and Neuromodulation Treatment

et al. 2023

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Fibromyalgia (FM) is a chronic pain disorder with unclear pathophysiological mechanisms, which leads to challenges in patient management. In addition to pain, the disorder presents with a broad range of symptoms, such as sleep disruption, chronic fatigue, brain fog, depression, muscle stiffness, and migraine. FM has a considerable female prevalence, and it has been shown that symptoms are influenced by the menstrual cycle and periods of significant hormonal and immunological changes. There is increasing evidence that females with FM experience an aggravation of symptoms in pregnancy, particularly during the third trimester and after childbirth. In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic “weakening” in a thalamocortical neural loop system. Based on our hypothesis, we introduce the possibility of utilizing transcranial direct current stimulation (tDCS) as a non-invasive treatment potentially capable of exerting sex-specific effects on FM patients.

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Section: Interactions Between Fm and Pregnancymentioning

confidence: 94%