Fibromyalgia Pathophysiology

Abstract

This article examines the biological, genetic, and environmental aspects of fibromyalgia that may have an impact on its pathogenesis. Symptoms of fibromyalgia may be related to aberrations in the endogenous inhibition of pain as well as changes in the central processing of sensory input. Genetic research has revealed familial aggregation of fibromyalgia and other related disorders like major depressive disorder. Dysfunctional pain processing may also be influenced by exposure to physical or psychological stressors, abnormal biologic reactions in the autonomic nervous system, and neuroendocrine responses. With more research the pathophysiology of fibromyalgia will be better understood, leading to more logical and focused treatment options for fibromyalgia patients.

Correlation between Different Psychological Variables in Women with Fibromyalgia with Symptoms of Neurogenic Inflammation: A Cross-Sectional Study

“…Research into the pathophysiological mechanisms responsible for the pain suffered by patients with FM is of great interest in the scientific community [ 12 ]. Several alterations in the nociceptive system have been identified, including the transmission, processing and modulation of painful stimuli [ 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model

“…Classic fibromyalgia symptoms often begin after a triggering event and progressively accumulate without eliciting occurrence. Fibromyalgia often occurs in women who also have tension headaches, irritable bowel syndrome, anxiety, and depression [ 1 , 2 , 3 ]. Currently, there is no cure for fibromyalgia, medication can only manage the symptoms.…”

Mechanisms of transcranial direct current stimulation (tDCS) for pain in patients with fibromyalgia syndrome

“…Persistent musculoskeletal pain was linked to worse physical and cognitive function, burdening individuals and society ( Xu et al, 2023 ; Zheng et al, 2023 ). Along with musculoskeletal pain, people with FMS often report fatigue, dyscognition, stiffness, sleep disturbances, mood issues, and hypervigilance, further reducing quality of life ( Arnold et al, 2019 ; Gyorfi et al, 2022 ). FMS affects 2–4% of people worldwide ( Häuser and Fitzcharles, 2018 ), with 7% of women aged 50–80 affected ( White and Robinson, 2015 ).…”