Fibromyalgia, sleep disturbance and menopause: Is there a relationship? A literature review

Dias, Rejane Camila Alvarenga; Kulak, Jaime; Costa, Eloise Haydeê Ferreira da; Nisihara, Renato

doi:10.1111/1756-185x.13713

Cited by 21 publications

(12 citation statements)

References 40 publications

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“…Chronic pain often leads to further psychiatric disorders such as anxiety and depression, which significantly affect the health-related quality of life [2][3][4]. Sleep disorders are the most common psychiatric disorders related to pain [5][6][7][8],…”

Section: Introductionmentioning

confidence: 99%

Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation

et al. 2022

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Both chronic pain and sleep disorders are associated with a reduction in the quality of life. They can be both a cause and a consequence of each other, and should therefore be simultaneously treated. However, optimal treatments for chronic pain-related sleep disorders are not well established. Here, we aimed to investigate the effects of suvorexant, a novel sleep drug, and mirtazapine, a noradrenergic and specific serotonergic antidepressant, on pain-related changes in sleep parameters in a preclinical chronic pain mice model, by partial sciatic nerve ligation. We evaluated the quantity, duration, and depth of sleep by analyzing the electroencephalogram and voluntary activity by counting the number of wheel rotations to determine various symptoms of sleep disorders, including reduced total sleep time, fragmentation, low quality, and impaired activity in the daytime. Suvorexant and mirtazapine normalized the reduction in sleep time and fragmented sleep, further regaining the sleep depth at sleep onset in the chronic pain state in nerve-ligated mice. Mirtazapine also increased the percentage of rapid eye movement sleep in mice. Suvorexant decreased voluntary activity, which was prolonged after administration; however, mirtazapine did not decrease it. Although the effects of suvorexant and mirtazapine on sleep and activity are different, both suvorexant and mirtazapine could be potential therapeutic agents for chronic pain-related sleep disorders.

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Section: Introductionmentioning

confidence: 99%

Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation

et al. 2022

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“…The study samples consisted of 150 women with a mean age of 42. 35 = 0.001, respectively). Besides, those with no history of depression had higher scores on the mental health subscale (52.4 ± 18.5 Vs. 44.4 ± 16.8, P-value = 0.007).…”

Section: Resultsmentioning

confidence: 90%

“…In other words, QoL has decreased with the onset of menopause. Studies have further shown that symptoms of premature or surgical menopausal hormone deficiency, as well as stress and mood swings, can lead to sleep disturbances and may be responsible for the onset or worsening of FMS-related symptoms and QoL (35,36).…”

Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life and Related Factors in Patients with Fibromyalgia: A Cross-sectional Study

Jafari

Mobini

Moradi

et al. 2022

Iran J Psychiatry Behav Sci

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Background: Fibromyalgia syndrome (FMS) is a chronic musculoskeletal condition, which can reduce the quality of life (QoL). Objectives: This study aimed to evaluate the impact of FMS on health-related quality of life (HRQoL) and the possible related factors such as sociodemographic and psychological variables. Methods: In this cross-sectional study, 150 women patients with FMS were included who visited a psychosomatic clinic at a referral center in northern Iran. The samples were selected in a consecutive procedure from April 2019 to March 2019. Sociodemographic variables, HRQoL score [36-Item Short Form (SF-36) Health Survey], and the Pittsburgh Sleep Quality Index (PSQI) were recorded. Data were analyzed using the SPSS Statistics software (ver. 24). The quantitative data were reported as mean ± SD, and the qualitative variables were presented as frequency and percentage. Also, analysis was performed using analytical tests such as chi-square test (χ2). P < 0.05 was considered to be significant. Results: The mean (SD) age was 42.35 (11.73) years. The mean physical and mental health scores were 33.45 (16.22) and 48.99 (18.19), respectively. Moreover, 88% of patients had moderate-to-severe sleep disorder, and those who did not, had a better physical and mental health status [42.7 (14.1) vs. 32.2 (16.1), P-value = 0.009 and 62.2 (16.3) vs. 47.2 (17.7), P-value = 0.001, respectively]. History of depression according to self-reporting was associated with worse mental health subscale scores [44.4 (16.8 Vs. 52.4 (18.5), P-value = 0.007], and lower scores in social functioning and emotional well-being (P-value = 0.012, P-value = 0.001, respectively). Being postmenopausal was associated with a lower physical health quality (P-value = 0.049). Body Mass Index (BMI) reversely correlated with HRQoL subscales (r = -0.163, P-value = 0.046), but the subscales were not affected by the level of income (P-value = 0.644, P-value = 0.170, respectively). Conclusions: Patients with fibromyalgia report a considerable significant impact on their quality of life and impaired sleep quality. Assessment of sleep quality and QoL are needed in patients with fibromyalgia.

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“…Pain, and particularly chronic pain, is very common in the general population, affecting 30% of women [61,62]. At menopausal age, pain can easily affect a woman's behavior, lowering the time spent walking and moving in general.…”

Section: Discussionmentioning

confidence: 99%

Soy-enriched bread, a pilot study to determine its beneficial effects in menopause

Giustarini¹,

Ricci²,

Ceccarelli³

et al. 2021

Preprint

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Menopause is the last step in the reproductive history of a woman. The ovaries stop producing hormones and the body reacts by lowering its functions, including the neuronal one. Phytoestrogens are plant products with estrogen-like activity able to affect many body functions. The aim of the present experiment was to study the effects of 30 days of regular consumption of a soy-enriched bread containing a known amount of phytoestrogens (genistein and daidzein). Women at climacteric, within 5 years or more than 5 years of menopause, were asked to include in their diet 200 g/day of a bread containing 40 mg of phytoestrogens. The effect on common menopausal symptoms and neurophysiological, hormonal and antioxidant parameters were determined before and after 30 days through questionnaires and experimental tests. Phytoestrogens were measured in the urine. In all groups, there was a significant increase of phytoestrogens in the urine and a decrease of the classical symptoms of menopause as well as a significant improvement in attentional performance tests, the quality of life index and pain intensity. Phytoestrogens present in the soy-enriched bread, are an important supplement in aging women due to their ability to induce estrogen-like effects without the potential side effects of estrogens.

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Fibromyalgia, sleep disturbance and menopause: Is there a relationship? A literature review

Cited by 21 publications

References 40 publications

Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation

Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation

Health-Related Quality of Life and Related Factors in Patients with Fibromyalgia: A Cross-sectional Study

Soy-enriched bread, a pilot study to determine its beneficial effects in menopause

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