Fibromyalgia Syndrome is Associated with Hypocortisolism

Riva, Roberto; Mork, Paul Jarle; Westgaard, Rolf H.; Rø, Magne; Lundberg, Ulf

doi:10.1007/s12529-010-9097-6

Cited by 121 publications

(114 citation statements)

References 68 publications

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“…Recent research indicates that FM patients exhibit hypocortisolism, particularly as an attenuated cortisol awakening response [53]. In the present study, 11% of FMS patients were having higher levels of cortisol hormone, while in 10 controls also, cortisol level was higher.…”

Section: Cortisol Abnormalities In Fmssupporting

confidence: 47%

Is Fibromyalgia a Syndrome of Hormonal Imbalance?

Tanwar

Mattoo

Kumar

et al. 2018

Asian J Pharm Clin Res

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Objectives: The present study was conducted to estimate cortisol and thyroid-stimulating hormone (TSH) levels in patients with fibromyalgia syndrome (FMS) and to find correlation if any between hormone levels and pain duration in FMS.Methods: Plasma cortisol and TSH concentration were determined by electro chemiluminescence immunoassay in 89 female patients with FMS and 74 age-matched healthy women.Results: No significant difference in TSH level was observed between FMS and healthy subjects. Ten patients had higher cortisol levels than the standard reference range, 48 patients with reduced cortisol and 31 patients with normal cortisol levels. No significant correlation was observed between pain duration and levels of cortisol. Conclusion:The study has confirmed the equivocal data regarding cortisol/hypothalamic-pituitary-adrenal axis related dysfunction in FMS. To the best of our knowledge, it is the first Indian study on FMS which assessed the cortisol and TSH levels and their correlation with pain duration if any.

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Section: Cortisol Abnormalities In Fmssupporting

confidence: 47%

Is Fibromyalgia a Syndrome of Hormonal Imbalance?

Tanwar

Mattoo

Kumar

et al. 2018

Asian J Pharm Clin Res

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“…51 An enhanced negative feedback sensitivity of the HPA-axis has also been demonstrated in unexplained syndromes associated with pain which show comorbidity with depression. For example, patients with fibromyalgia, 28,29 chronic myogenous facial pain, 20 and chronic whiplash-associated disorder 33 exhibit lowered post-DST cortisol levels. Finally, both burn-out and chronic fatigue syndrome, which are associated with increased depressive symptomatology, have also been reported to exhibit hypoactivity of the HPA-axis.…”

Section: Discussionmentioning

confidence: 99%

“…5,7,8 The present study focuses on the HPA-axis, which plays a central role in the neuroendocrine response to stress with cortisol being it's main effector constituent, since both IBS and depression have been reported to exhibit HPAaxis dysregulation and that stress-dysregulation has been suggested as one important etiologic factor in both conditions. [9][10][11][12][13][14][15][16][17][18] While stress has traditionally been associated with increased cortisol levels and HPA-axis hyperactivity, there is a growing body of literature describing lowered cortisol levels and hypoactivity of the HPA-axis in a number of stress related disorders [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] ; eg, posttraumatic stress disorder (PTSD), 30,31 chronic fatigue syndrome, [22][23][24] burnout, 25,26 as well as in fibromyalgia and chronic somatic pain conditions of unknown or uncertain etiology. 28,29,[32][33][34] Dysfunction of the HPA-axis, including hypoactivity, has also been reported in IBS.…”

Section: Introductionmentioning

confidence: 99%

Hypothalamus-Pituitary-Adrenal Axis Hypersuppression Is Associated with Gastrointestinal Symptoms in Major Depression

Karling

Wikgren

Adolfsson

et al. 2016

J Neurogastroenterol Motil

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Background/AimsGastrointestinal symptoms and hypothalamus-pituitary-adrenal (HPA) axis dysfunction are frequently observed in patients with major depression. The primary aim of the study was to investigate the relationship between HPA-axis function and self-perceived functional gastrointestinal symptoms in major depression. MethodsPatients with major depression (n = 73) and controls representative of the general population (n = 146) underwent a weightadjusted very low dose dexamethasone suppression test (DST). Patients and controls completed the gastrointestinal symptom rating scale-iritable bowel syndrome (GSRS-IBS) and the hospital anxiety depression scale. Medical records of the patients were screened over a ten year period for functional gastrointestinal disorder and pain conditions. ResultsPatients with high GSRS-IBS scores (above median) exhibited HPA-axis hypersuppression more often than controls (defined by the lowest 10% cutoff of the post-DST cortisol values among controls, adjusted OR 7.25, CI 1.97-26.7) whereas patients with low GSRS-IBS scores did not differ from controls concerning their post-DST cortisol values. Patients who had consulted primary care for functional gastrointestinal disorder (P = 0.039), lumbago (P = 0.006) and chronic multifocal pain (P = 0.057) also exhibited an increased frequency of hypersuppression. Conclusions

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“…Nonetheless, a number of studies have now reported hypercortisolism associated with a variety of medical conditions, including fibromyalgia (Riva, Mork, Westgaard, Rø, & Lundberg, 2010), post-traumatic stress disorder (Bicanic et al, 2013), and chronic fatigue syndrome (Papadopoulos & Cleare, 2012).…”

Section: Discussionmentioning

confidence: 99%