Fibromyxoma of the Petrous Apex

Srinivasan, U

doi:10.1159/000028936

Cited by 9 publications

(8 citation statements)

References 5 publications

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“…With respect to RT, Guha-Thakurta et al 8 noted that it is used only to reduce the size of large tumors and that preoperative embolization can be used to decrease the vascularity during resection. Sato et al, 32 Osterdock et al, 24 and Srinivasan 34 have reported that myxoid tumors are generally insensitive to RT and that postoperative RT has no therapeutic effect on myxomas of the bone in other areas; therefore, RT after surgery is unnecessary. However, Zhang et al 40 reported that among 8 cases receiving postoperative RT, 4 cases did not recur within the followup period.…”

Section: Progression-free Survival and Risk Factorsmentioning

confidence: 99%

Surgical management and prognostic factors for primary intracranial myxoma: a single-institute experience with a systematic review

Weng

Song

et al. 2019

Journal of Neurosurgery

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OBJECTIVEPrimary intracranial myxomas (PICMs) are extremely rare neoplasms, and their management and prognostic factors remain ambiguous. The authors aimed to elaborate the radiological features, evaluate the risk factors for progression-free survival (PFS), and propose a treatment protocol based on pooled data from cases treated at their institute and those found in the literature.METHODSClinical data from all cases of PICMs treated at the authors’ institute and those cases reported in the English-language literature between 1987 and December 2017 were reviewed. The authors searched the Ovid MEDLINE, Embase, PubMed, and Cochrane databases using the keywords “myxoma” and “central nervous system,” “intracranial,” “cerebral,” “skull base,” “skull,” or “brain.” Previously published data were processed and used according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Risk factors in the pooled cohort were evaluated.RESULTSCases from the authors’ institute included 21 males and 9 females, with a mean age of 35.7 ± 1.7 years. Gross-total resection (GTR) and non-GTR were achieved in 6 (20.0%) and 24 (80.0%) patients, respectively. After a mean follow-up of 86.7 ± 14.1 months, recurrence occurred in 6 (24%) patients, for a median PFS time of 85.2 months (range 36.0–136.0 months) and no deaths. In the literature between 1987 and 2017, 35 cases of PICM were identified in 14 males and 21 females with a mean age of 31.7 ± 3.2 years. GTR and non-GTR were achieved in 23 (65.7%) and 9 (25.7%) cases, respectively. After a mean follow-up of 25.8 ± 6.9 months (range 1.0–156.0 months), recurrence occurred in 4 (14.3%) patients, for a median PFS time of 11.0 months (range 3.0–36.0 months) and no deaths. Actuarial PFS rates at 1, 5, and 10 years were 93.0%, 80.6%, and 67.9%, respectively. A multivariate model demonstrated that GTR (HR 0.058, 95% CI 0.005–0.680, p = 0.023) was the only factor that favored PFS.CONCLUSIONSPICMs are rare neoplasms with a slightly higher occurrence in males. GTR was the only favorable factor for PFS. Based on statistical results, GTR alone, if tolerable, is advocated as the optimal treatment for PICM. Nevertheless, conservative excision may be preferred to avoid damage to vital structures. PICMs have a tendency to recur within a few years of the initial surgery if resection is incomplete; therefore, close postoperative follow-up is mandatory. Future studies with larger cohorts are necessary to verify the study findings.Systematic review registration no.: CRD42018091517 (www.crd.york.ac.uk/prospero/)

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Section: Progression-free Survival and Risk Factorsmentioning

confidence: 99%

Surgical management and prognostic factors for primary intracranial myxoma: a single-institute experience with a systematic review

Weng

Song

et al. 2019

Journal of Neurosurgery

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“…A comparable histopathology was identified in three other cases 12–14 (Table I). Histopathologic identification of proliferating fibroblasts‐fibrous tissue bands in the stroma, 15 fibromyxoid components, vascular spaces, cystic areas, focal fibrous and bony tissue, 16 atypical cellular elements, lipoblasts and mineralization, 17 abundant vascularity 18 or mitotic activity, bone areas with osteoblastic activity, and cysts as sign of degeneration 11 excluded these cases from the group of true primary myxomas. Moreover, one case clearly revealed a myxoma that was finally identified to be a metastasis from an atrial myxoma 19 .…”

Section: Resultsmentioning

confidence: 99%

“…Currently, for the head and neck region, myxomas are considered as a lesion that may derive from tooth germ cells, originating from the dental papilla, because of its predilection for the jaws in young adults, the presence of remnant odontogenic tissue within the tumor, and the association with unerupted teeth (i.e., odontogenic myxoma) 20 . Others believe that myxomas arise from primitive embryonic mesenchyme or fibroblasts with abundant proliferation of mucopolysaccharides because of its resemblance to the primitive connective tissue of the embryo 8,15,21 . The theory that it may arise from myxoblast cells or is a modified form of fibroma is not yet commonly accepted 22 .…”

Section: Discussionmentioning

confidence: 99%

Myxoma of the Lateral Skull Base: Clinical Features and Management

Windfuhr

Schwerdtfeger

2004

The Laryngoscope

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“…2 Fibromyxoma of petrous apex has also been reported. 3,4 This case is described to highlight the clinical presentation and management of this relatively rare neoplasm.…”

Section: Introductionmentioning

confidence: 98%