Fibrosarcoma of the mediastinum

Barua, Nil R.; Patel, Arun R.; Takita, Hiroshi; Jennings, E. C.

doi:10.1002/jso.2930120103

Cited by 22 publications

(1 citation statement)

References 13 publications

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“…Evaluation of these tumors can be made using various tests such as chest radiography, conventional radiography, CT angiography, bronchoscopy, sputum studies, and skin tests. 13 The thoracotomy and biopsy of the mediastinal mass is the most common method. Signs and symptoms depend on the size and location of the mass and may be variable.…”

Section: Discussionmentioning

confidence: 99%

A High Serum-Ascites Albumin Gradient and Mediastinal Fibrosarcoma: A Case Report

Hormati

Jameshorani

Sarkeshikian

et al. 2018

Middle East J Dig Dis

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Accumulation of free fluid in the peritoneal cavity is called ascites. The first step in identifying its etiology is to determine the serum-ascites albumin gradient (SAAG). According to this parameter, a high SAAG is regarded as a gradient greater than 1.1 g/dL. This condition has some differential diagnoses such as liver cirrhosis, Budd-Chiari syndrome, heart failure, and idiopathic portal fibrosis. In the present article, we present a young man with abdominal distention due to a high SAAG. Further evaluation of the abdominal and thoracic cavity revealed a mass in the posterior mediastinum, which had compressed the inferior vena cava and left atrium and led to Budd-Chiari syndrome. Evaluation of the biopsy sample showed fibrosarcoma. Mediastinal fibrosarcomas, though rare, should be considered in the differential diagnosis of mediastinal masses.

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Section: Discussionmentioning

confidence: 99%

A High Serum-Ascites Albumin Gradient and Mediastinal Fibrosarcoma: A Case Report

Hormati

Jameshorani

Sarkeshikian

et al. 2018

Middle East J Dig Dis

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The intrathymic expression of insulin-related genes: implications for pathophysiology and prevention of Type 1 diabetes

Geenen

Lefèbvre

1998

Diabetes Metab. Rev.

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Recent experimental work has challenged and shattered the old concept of a sequestration of pancreatic islet antigens from developing T-cells within the thymic environment. There is now compelling evidence that the central immunological tolerance of the whole insulin family may be induced during the process of T-cell ontogeny in the thymus. Transcripts of insulin-like growth factor II (IGF-II), IGF-I and insulin genes have been characterized in human, rat and mouse thymuses. At the peptide level, IGF-II was shown to be the dominant polypeptide of the insulin family in the thymus from different species. Data are presented which support a dual role of thymic IGF-II both in T-cell development as well as in T-cell negative selection. Using animal models of autoimmune diabetes, current research is investigating the hypothesis that a defect of thymic T-cell education to the insulin family is implicated in the pathophysiology of human Type 1 diabetes. An efficient and secure prevention of Type 1 diabetes could be designed on the basis of the strong natural tolerogenic properties of the thymus.

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Mesenchymal Tumors of the Mediastinum

Weissferdt

2020

Diagnostic Thoracic Pathology

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Fibrosarcoma of the mediastinum

Abstract: Fibrosarcoma is a rare primary malignant tumor of the mediastinum. Three cases are presented with different presenting symptoms and clinical manifestations. Thoracotomy with biopsy of the mass is the only method for arriving at a definitive histologic diagnosis.

Cited by 22 publications

References 13 publications

A High Serum-Ascites Albumin Gradient and Mediastinal Fibrosarcoma: A Case Report

A High Serum-Ascites Albumin Gradient and Mediastinal Fibrosarcoma: A Case Report

The intrathymic expression of insulin-related genes: implications for pathophysiology and prevention of Type 1 diabetes

Mesenchymal Tumors of the Mediastinum

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