2022
DOI: 10.1155/2022/2760027
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Fibrosis-4 Index Is Closely Associated with Arterial Damage and Future Risk of Coronary Heart Disease in Type 2 Diabetes

Abstract: This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet count, was calculated for all subjects. Carotid intima-media thickness (IMT), carotid artery calcification (CAC), and aortic arch calcification (AAC) grade (0–2… Show more

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Cited by 3 publications
(2 citation statements)
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“…There may be a similar relationship between the heart and the liver, through a “cardio-hepatic syndrome” [ 2 , 3 ]. Recently, there have been several reports on the association between hepatic fibrosis and cardiovascular disease including coronary artery disease (CAD) [ 4 , 5 , 6 , 7 , 8 ], although the number of papers is small. A history of cardiovascular disease in 6087 patients without known liver disease who had participated in an annual health checkup examination was significantly more common in subjects with a high fibrosis-4 index (FIB-4I), which is an index of the severity of liver fibrosis [ 4 ].…”
Section: Introductionmentioning
confidence: 99%
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“…There may be a similar relationship between the heart and the liver, through a “cardio-hepatic syndrome” [ 2 , 3 ]. Recently, there have been several reports on the association between hepatic fibrosis and cardiovascular disease including coronary artery disease (CAD) [ 4 , 5 , 6 , 7 , 8 ], although the number of papers is small. A history of cardiovascular disease in 6087 patients without known liver disease who had participated in an annual health checkup examination was significantly more common in subjects with a high fibrosis-4 index (FIB-4I), which is an index of the severity of liver fibrosis [ 4 ].…”
Section: Introductionmentioning
confidence: 99%
“…A history of cardiovascular disease in 6087 patients without known liver disease who had participated in an annual health checkup examination was significantly more common in subjects with a high fibrosis-4 index (FIB-4I), which is an index of the severity of liver fibrosis [ 4 ]. FIB4-I is closely associated with CAD in type 2 diabetes mellitus (DM) [ 5 ] and in metabolic-associated fatty liver disease [ 6 ]. FIB-4I is a valuable biomarker for predicting not only liver-related events but also extrahepatic cancers and major adverse cardiovascular events (MACEs) [ 7 ].…”
Section: Introductionmentioning
confidence: 99%