Fibrosis and cancer: A strained relationship

Piersma, Bram; Hayward, Mary-Kate; Weaver, Valerie M.

doi:10.1016/j.bbcan.2020.188356

Cited by 422 publications

(338 citation statements)

References 184 publications

(230 reference statements)

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“…The presence of CAFs in many solid tumors such as pancreatic, lung, colon and breast cancers has been recognized for many years. They contribute to a desmoplastic reaction, increase tumor tissue stiffness and promote the proliferation and invasion of cancer cells [ 7 , 8 ]. CAFs represent a heterogeneous population of mesenchymal cells expressing a variety of markers such as fibroblast specific protein (FSP)-1 (aka S100A4), fibroblast activation protein-α (FAP)-α, (aka dipeptidyl peptidase IV), α-SMA, platelet-derived growth factor receptor (PDGFR)-β, and β1 integrin (CD29) in addition to other proteins such as thrombospondin-1, tenascin-C, stromelysin, desmin-1, and VEGF-A [ 9 , 10 ].…”

Section: Cafs New Players Cooperating With Tams In Nb Progressionmentioning

confidence: 99%

The Tumor Microenvironment in Neuroblastoma: New Players, New Mechanisms of Interaction and New Perspectives

Blavier

Yang

DeClerck

2020

Cancers

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The contribution of the tumor microenvironment (TME) to cancer progression has been well recognized in recent decades. As cancer therapeutic strategies are increasingly precise and include immunotherapies, knowledge of the nature and function of the TME in a tumor becomes essential. Our understanding of the TME in neuroblastoma (NB), the second most common solid tumor in children, has significantly progressed from an initial focus on its Schwannian component to a better awareness of its complex nature, which includes not only immune but also non-immune cells such as cancer-associated fibroblasts (CAFs), the contribution of which to inflammation and interaction with tumor-associated macrophages (TAMs) is now recognized. Recent studies on the TME landscape of NB tumors also suggest significant differences between MYCN-amplified (MYCN-A) and non-amplified (MYCN-NA) tumors, in their content in stromal and inflammatory cells and their immunosuppressive activity. Extracellular vesicles (EVs) released by cells in the TME and microRNAs (miRs) present in their cargo could play important roles in the communication between NB cells and the TME. This review article discusses these new aspects of the TME in NB and the impact that information on the TME landscape in NB will have in the design of precise, biomarker-integrated clinical trials.

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Section: Cafs New Players Cooperating With Tams In Nb Progressionmentioning

confidence: 99%

The Tumor Microenvironment in Neuroblastoma: New Players, New Mechanisms of Interaction and New Perspectives

Blavier

Yang

DeClerck

2020

Cancers

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“…Not surprisingly, tumor aggression and poor patient prognosis correlate with degree of tissue fibrosis in addition to the level of stromal stiffness [ 101 ]. Fibrosis promoting malignancy is a result of extracellular matrix (ECM) remodeling, deposition and cross-linking.…”

Section: Targets Of Resveratrol In Tumor Microenvironmentmentioning

confidence: 99%

Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets

et al. 2020

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Resveratrol (3,4′,5 trihydroxystilbene) is a naturally occurring non-flavonoid polyphenol. It has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory and anti-cancer. Many studies have given special attention to different aspects of resveratrol anti-cancer properties and proved its high efficiency in targeting multiple cancer hallmarks. Tumor microenvironment has a critical role in cancer development and progression. Tumor cells coordinate with a cast of normal cells to aid the malignant behavior of cancer. Many cancer supporting players were detected in tumor microenvironment. These players include blood and lymphatic vessels, infiltrating immune cells, stromal fibroblasts and the extracellular matrix. Targeting tumor microenvironment components is a promising strategy in cancer therapy. Resveratrol with its diverse biological activities has the capacity to target tumor microenvironment by manipulating the function of many components surrounding cancer cells. This review summarizes the targets of resveratrol in tumor microenvironment and the mechanisms involved in this targeting. Studies discussed in this review will participate in building a solid ground for researchers to have more insight into the mechanism of action of resveratrol in tumor microenvironment.

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Section: Cafs In Bone Metastasis Formationmentioning

confidence: 99%

“…CAFs regulate ECM deposition, remodeling, and cross-linking, thereby stiffening stroma [ 95 ]. The resultant rigid stroma can enhance cancer cell survival, growth, and migration, induce its EMT, enhance hypoxia and subsequent angiogenesis, and compromise tumor immunity [ 95 , 96 ]. ECM solidification activates glycolysis in CAFs, which provided aspartate to sustain cancer cell proliferation and simultaneously triggered glutamine metabolism in cancer cells, which consequently balanced the redox states of CAFs to accelerate ECM modeling [ 97 ].…”

Section: Cafs In Bone Metastasis Formationmentioning

confidence: 99%

Emergence of Cancer-Associated Fibroblasts as an Indispensable Cellular Player in Bone Metastasis Process

Mukaida

Zhang

Sasaki

2020

Cancers

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Bone metastasis is frequently complicated in patients with advanced solid cancers such as breast, prostate and lung cancers, and impairs patients’ quality of life and prognosis. At the first step of bone metastasis, cancer cells adhere to the endothelium in bone marrow and survive in a dormant state by utilizing hematopoietic niches present therein. Once a dormant stage is disturbed, cancer cells grow through the interaction with various bone marrow resident cells, particularly osteoclasts and osteoblasts. Consequently, osteoclast activation is a hallmark of bone metastasis. As a consequence, the drugs targeting osteoclast activation are frequently used to treat bone metastasis but are not effective to inhibit cancer cell growth in bone marrow. Thus, additional types of resident cells are presumed to contribute to cancer cell growth in bone metastasis sites. Cancer-associated fibroblasts (CAFs) are fibroblasts that accumulate in cancer tissues and can have diverse roles in cancer progression and metastasis. Given the presence of CAFs in bone metastasis sites, CAFs are emerging as an important cellular player in bone metastasis. Hence, in this review, we will discuss the potential roles of CAFs in tumor progression, particularly bone metastasis.

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Fibrosis and cancer: A strained relationship

Cited by 422 publications

References 184 publications

The Tumor Microenvironment in Neuroblastoma: New Players, New Mechanisms of Interaction and New Perspectives

The Tumor Microenvironment in Neuroblastoma: New Players, New Mechanisms of Interaction and New Perspectives

Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets

Emergence of Cancer-Associated Fibroblasts as an Indispensable Cellular Player in Bone Metastasis Process

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