Fibrosis as an Indication of Time in Infiltrating Breast Cancer and its Importance in Prognosis

Anastassiades, O. Th.; Pryce, D. M.

doi:10.1038/bjc.1974.62

Cited by 23 publications

(14 citation statements)

References 18 publications

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“…4. These women were prospectively randomized so that those with clinically negative axillae were treated by either radical mastectomy, total (simple) mastectomy a n d irradiation, or total mastectomy only.…”

Section: ~I a T E R I A L S And M E T I~o D Smentioning

confidence: 99%

See 1 more Smart Citation

The pathology of invasive breast cancerA Syllabus Derived from Findings of the National Surgical Adjuvant Breast Project (Protocol No. 4)

Fisher

Gregorio²,

Fisher³

et al. 1975

Cancer

717

140

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The inter-relationships of 32 pathologic and 7 clinical parameters encountered in the study of 1000 examples of invasive breast carcinoma have been presented. In some instances the biological significance of these associations is at present unclear. In others it is to be noted that there is no information provided as to the rank of their significance. Nevertheless, the associations that were encountered not only help further characterize the various forms of breast cancer but also provide information regarding the possible biological significance of some of their features. Although it is not our intention to minimize the possible significance of the inter-relationships of pathologic parameters, most emphasis in the summarizing statements which follow has been placed upon those correlations which may relate to prognosis. In this regard reference has been made to short-term treatment failure, vis a vis local recurrence and/or metastases, which may not necessarily accurately reflect patient survival, although generally such a relationship exists. Information in this regard as well as to the rank of the significance of these pathologic features shall be forthcoming when sufficient time has elapsed since the inception of this study to allow for such conclusions, i.e. survival or long-term treatment failure rates. Lastly, it becomes evident that the guidelines followed in the examination of these specimens appear to represent at least the minimum requirements necessary for a meaningful pathologic evaluation of breast carcinoma.

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Section: ~I a T E R I A L S And M E T I~o D Smentioning

confidence: 99%

“…4. A nosologic problem is presented by carcinomas totally or in part comprised of small or multinucleated giant or basaloid cells.…”

Section: Absent Tumor Necrosismentioning

confidence: 99%

The pathology of invasive breast cancerA Syllabus Derived from Findings of the National Surgical Adjuvant Breast Project (Protocol No. 4)

Fisher

Gregorio²,

Fisher³

et al. 1975

Cancer

717

140

View full text Add to dashboard Cite

show abstract

“…In addition, via their interactions with cell-surface receptors, or with growth factors, ECM proteins provide biochemical signals that control various cellular processes such as proliferation, survival, and differentiation of both normal and tumor cells456. ECM deposition is a hallmark of cancers and has been used by pathologists as a poor-prognosis factor, long before the complexity of the ECM was even appreciated7.…”

mentioning

confidence: 99%

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression

Naba

Clauser

Mani

et al. 2017

Sci Rep

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The angiogenic switch, the time at which a tumor becomes vascularized, is a critical step in tumor progression. Indeed, without blood supply, tumors will fail to grow beyond 1 mm3 and are unlikely to disseminate. The extracellular matrix (ECM), a major component of the tumor microenvironment, is known to undergo significant changes during angiogenesis and tumor progression. However the extent of these changes remains unknown. In this study, we used quantitative proteomics to profile the composition of the ECM of pancreatic islets in a mouse model of insulinoma characterized by a precisely timed angiogenic switch. Out of the 120 ECM proteins quantified, 35 were detected in significantly different abundance as pancreatic islets progressed from being hyperplastic to angiogenic to insulinomas. Among these, the core ECM proteins, EFEMP1, fibrillin 1, and periostin were found in higher abundance, and decorin, Dmbt1, hemicentin, and Vwa5 in lower abundance. The angiogenic switch being a common feature of solid tumors, we propose that some of the proteins identified represent potential novel anti-angiogenic targets. In addition, we report the characterization of the ECM composition of normal pancreatic islets and propose that this could be of interest for the design of tissue-engineering strategies for treatment of diabetes.

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“…Desmoplasia is significantly associated with invasive breast cancer and decreased relapse-free and overall survival. [13][14][15] Although uniform in their spindle-shaped appearance, fibroblasts may be identified by the expression of several different mesenchymal markers, including distinct non-overlapping markers such as α-smooth muscle actin and fibroblast-specific protein 1 (Fsp1). [16][17][18] As a key cellular component of the microenvironment, fibroblasts influence the growth and progression of breast cancers directly and indirectly, through secretion of growth factors, matrix proteins and angiogenic factors, as demonstrated through animal studies.…”

mentioning

confidence: 99%

Elevated expression of chemokine C-C ligand 2 in stroma is associated with recurrent basal-like breast cancers

Yao

Staggs

et al. 2016

Modern Pathology

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Despite advances in treatment, up to 30% of breast cancer patients experience disease recurrence accompanied by more aggressive disease and poorer prognosis. Treatment of breast cancer is complicated by the presence of multiple breast cancer subtypes, including: luminal, Her2 overexpressing, and aggressive basal-like breast cancers. Identifying new biomarkers specific to breast cancer subtypes could enhance the prediction of patient prognosis and contribute to improved treatment strategies. The microenvironment influences breast cancer progression through expression of growth factors, angiogenic factors and other soluble proteins. In particular, chemokine C-C ligand 2 (CCL2) regulates macrophage recruitment to primary tumors and signals to cancer cells to promote breast tumor progression. Here we employed a software-based approach to evaluate the prognostic significance of CCL2 protein expression in breast cancer subtypes in relation to its expression in the epithelium or stroma or in relation to fibroblast-specific protein 1 (Fsp1), a mesenchymal marker. Immunohistochemistry analysis of tissue microarrays revealed that CCL2 significantly correlated with Fsp1 expression in the stroma and tumor epithelium of invasive ductal carcinoma. In the overall cohort of invasive ductal carcinomas (n = 427), CCL2 and Fsp1 expression in whole tissues, stroma and epithelium were inversely associated with cancer stage and tumor size. When factoring in molecular subtype, stromal CCL2 was observed to be most highly expressed in basal-like breast cancers. By Cox regression modeling, stromal CCL2, but not epithelial CCL2, expression was significantly associated with decreased recurrence-free survival. Furthermore, stromal CCL2 (HR = 7.51 P = 0.007) was associated with a greater hazard than cancer stage (HR = 2.45, P = 0.048) in multivariate analysis. These studies indicate that stromal CCL2 is associated with decreased recurrence-free survival in patients with basal-like breast cancer, with important implications on the use of stromal markers for predicting patient prognosis.

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Fibrosis as an Indication of Time in Infiltrating Breast Cancer and its Importance in Prognosis

Cited by 23 publications

References 18 publications

The pathology of invasive breast cancerA Syllabus Derived from Findings of the National Surgical Adjuvant Breast Project (Protocol No. 4)

The pathology of invasive breast cancerA Syllabus Derived from Findings of the National Surgical Adjuvant Breast Project (Protocol No. 4)

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression

Elevated expression of chemokine C-C ligand 2 in stroma is associated with recurrent basal-like breast cancers

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