Fibrosis in canine transmissible venereal tumor after chemotherapy with vincristine

Abstract

The canine transmissible venereal tumor is type of transmissible cancer that occurs naturally through allogenic cellular transplants. Commonly diagnosed in the genital area of sexually active dogs, the tumor typically responds well to vincristine sulfate chemotherapy, although there are cases of resistance to the drug correlated with the tumoral phenotype. We describe herein a case of fibrosis in an area affected by the tumor in a dog after vincristine chemotherapeutic treatment that was associated with an idiosyncratic reaction to the drug.

Current Challenges in the Association between Canine Leishmaniasis and Malignant Disorders

“…Clinical signs often consist of genital lesions which, when present, may manifest as a single or multiple mass, friable on the foreskin or vulva [76,77,79], serosanguineous secretion, odor foul, and areas with or without necrosis [73]. In a case reported por Duzanski et al [79] dog's tumor initially adhered to the adjacent tissues, and developed to a friable hyperemic mass of the cauliflower aspect. Metastasis may occur with lymphatic or visceral spread usually associated with underlying immunological impairment.…”