Fibrosis Inhibition of Photobiomodulation Promoted Regeneration

Li, Xing-Er; La, Zhu; Liu, Timon Cheng-Yi

doi:10.1089/pho.2013.3513

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…These data was confirmed by the others studies, in which irradiation with the AsGaAl laser (635 nm, 7 mW) prevented the formation of fibrotic tissue [76]. Laser therapy inhibits fibrosis and accelerates muscle regeneration [77].…”

Section: Subgroupssupporting

confidence: 63%

Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine

Pissulin¹,

Fernandes

Orellana

et al. 2017

Journal of Photochemistry and Photobiology B: Biology

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Section: Subgroupssupporting

confidence: 63%

Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine

Pissulin¹,

Fernandes

Orellana

et al. 2017

Journal of Photochemistry and Photobiology B: Biology

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“…The dysfunctional nonessential function may be self-limited, but the dysfunctional essential function cannot be self-limited and its normalization may be promoted with a dPBM. For fibrosis [75], the nonessential oxidative stress or inflammation may be self-limited, but the delayed essential tissue self-regeneration can be promoted with a dPBM.…”

Section: Disease Treatment According Tomentioning

confidence: 99%

“…A PBM on the irradiated tissue should be decided by the tissue essential functions. For example, a dPBM on fibrosis can promote the delayed essential tissue self-regeneration [75]. A global PBM on an organism should be decided by the organism action, especially the normal action in its action-specific homeostasis (ASH).…”

Section: Action-dependent Organism Photobiomodulationmentioning

confidence: 99%

Action-Dependent Photobiomodulation on Health, Suboptimal Health, and Disease

Liu

Chen

et al. 2014

International Journal of Photoenergy

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The global photobiomodulation (PBM) on an organism was studied in terms of function-specific homeostasis (FSH) and scale-free functional network in this paper. A function can be classified into a normal function in its FSH and a dysfunctional function far from its FSH. An FSH-specific stress (FSS) disrupting an FSH can also be classified into a successful stress in its FSS-specific homeostasis (FSSH) and a chronic stress far from its FSSH. The internal functions of an organism can be divided into essential, special nonessential, and general nonessential functions. Health may be defined as a state of an organism in which all the essential and special nonessential functions are normal or their stresses are successful. Suboptimal health may be defined as a state of a disease-free organism in which only some special nonessential functions are dysfunctional in comparison with its healthy state. Disease may be defined as a state of an organism which is not in both health and suboptimal health. The global PBM of health, suboptimal health, or disease suggested that the PBM may depend on the organism action.

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Low-Level Laser Therapy Decreases Renal Interstitial Fibrosis

Oliveira

Sanders-Pinheiro

2013

Photomedicine and Laser Surgery

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Objective: the purpose of this study was to investigate the effect of low-level laser therapy (LLLT) on chronic kidney disease (CKD) in a model of unilateral ureteral obstruction (UUO). Background data: Regardless of the etiology, CKD involves progressive widespread tissue fibrosis, tubular atrophy, and loss of kidney function. This process also occurs in kidney allograft. At present, effective therapies for this condition are lacking. We investigated the effects of LLLT on the interstitial fibrosis that occurs after experimental UUO in rats. Methods: The occluded kidney of half of the 32 Wistar rats that underwent UUO received a single intraoperative dose of LLLT (AlGaAs laser, 780 nm, 22.5 J/cm 2 , 30 mW, 0.75 W/cm 2 , 30 sec on each of nine points). After 14 days, renal fibrosis was assessed by Sirius red staining under polarized light. Immunohistochemical analyses quantitated the renal tissue cells that expressed fibroblast (FSP-1) and myofibroblast (a-SMA) markers. Reverse transcriptase polymerase chain reaction (RT-PCR) was performed to determine the mRNA expression of interleukin (IL)-6, monocyte chemotactic protein-1 (MCP-1), transforming growth factor (TGF)-b1 and Smad3. Results: The UUO and LLLT animals had less fibrosis than the UUO animals, as well having decreased expression inflammatory and pro-fibrotic markers. Conclusions: For the first time, we showed that LLLT had a protective effect regarding renal interstitial fibrosis. It is conceivable that by attenuating inflammation, LLLT can prevent tubular activation and transdifferentiation, which are the two processes that mainly drive the renal fibrosis of the UUO model.

show abstract

Fibrosis Inhibition of Photobiomodulation Promoted Regeneration

Cited by 3 publications

References 17 publications

Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine

Low-level laser therapy (LLLT) accelerates the sternomastoid muscle regeneration process after myonecrosis due to bupivacaine

Action-Dependent Photobiomodulation on Health, Suboptimal Health, and Disease

Low-Level Laser Therapy Decreases Renal Interstitial Fibrosis

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