Fibrotic Response to Biomaterials and all Associated Sequence of Fibrosis

Jones, Kim S.

doi:10.1016/b978-0-12-800196-7.00009-8

Cited by 23 publications

(25 citation statements)

References 296 publications

(259 reference statements)

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“…Data are median of n=5-7 samples/group analyzed by Mann-Whitney U test; *P < 0.05 and **P < 0.01. fibrosis at 6 weeks and in turn stimulates Tgfb1 expression. A balance between TGFb and TIMP-1also aids nonfibrotic tissue repair (Jones, 2015). Tgfb also causes fibroblast deposition of ECM and secretion of many paracrine and autocrine growth factors, including CTGF (Leask et al, 2009) as confirmed by increased Ctgf gene expression in the presence of eMSCs.…”

Section: Discussionmentioning

confidence: 93%

“…Therefore, it is likely that fibroblasts participate in the later stages of inflammation by responding to Tgfb1, Il1b and Il6, proteins which increase matrix production, in addition to lipids such as prostaglandins and leukotrienes (Kendall and Feghali-Bostwick, 2014;Jones, 2015). Fibroblasts can also produce TGFb1, IL-1b, IL-33, CXC and CC-chemokines, and ROS, which serve to recruit and activate macrophages (Kendall and Feghali-Bostwick, 2014;Jones, 2015). Our results indicate that eMSC influence gene expression of these factors released in repairing tissues such as Tgfbs, Il1b, and Il6.…”

Section: Discussionmentioning

confidence: 99%

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Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor

et al. 2020

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Purpose: Transvaginal meshes for the treatment of Pelvic Organ Prolapse (POP) have been associated with severe adverse events and have been banned for clinical use in many countries. We recently reported the design of degradable poly L-lactic acid-co-poly e-caprolactone nanofibrous mesh (P nanomesh) bioengineered with endometrial mesenchymal stem/stromal cells (eMSC) for POP repair. We showed that such bioengineered meshes had high tissue integration as well as immunomodulatory effects in vivo. This study aimed to determine the key molecular players enabling eMSC-based foreign body response modulation.Methods: SUSD2 + eMSC were purified from single cell suspensions obtained from endometrial biopsies from cycling women by magnetic bead sorting. Electrospun P nanomeshes with and without eMSC were implanted in a NSG mouse skin wound repair model for 1 and 6 weeks. Quantitative PCR was used to assess the expression of extracellular matrix (ECM), cell adhesion, angiogenesis and inflammation genes as log 2 fold changes compared to sham controls. Histology and immunostaining were used to visualize the ECM, blood vessels, and multinucleated foreign body giant cells around implants.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor

et al. 2020

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“…Histologically, granulation tissue appears bright red and granular. It is a collection of small, microscopic blood vessels and is characterized by the proliferation of fibroblasts, accompanied by inflammatory cell infiltration [ 62 ]. Granulation tissue plays an important role in the process of wound healing and fill wounds, conferring protection from infection and further damage [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Preparation of Silk Fibroin/Carboxymethyl Chitosan Hydrogel under Low Voltage as a Wound Dressing

Chen

Zhang

Jiang

et al. 2021

IJMS

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At present, silk fibroin (SF) hydrogel can be prepared by means of electrodeposition at 25 V in direct current (DC) mode. Reducing the applied voltage would provide benefits, including lower fabrication costs, less risk of high voltage shocks, and better stability of devices. Here, a simple but uncommon strategy for SF-based hydrogel preparation using 4 V in DC mode is discussed. SF was mixed and cross-linked with carboxymethyl chitosan (CMCS) through hydrogen bonding, then co-deposited on the graphite electrode. The thickness, mass, and shape of the SF/CMCS hydrogel were easily controlled by adjusting the electrodeposition parameters. Morphological characterization of the prepared hydrogel via SEM revealed a porous network within the fabricated hydrogel. This structure was due to intermolecular hydrogen bonding between SF and CMCS, according to the results of thermogravimetric analysis and rheological measurements. As a potential wound dressing, SF/CMCS hydrogel maintained a suitable moisture environment for wound healing and demonstrated distinct properties in terms of promoting the proliferation of HEK-293 cells and antibacterial activity against Escherichia coli and Staphylococcus aureus. Furthermore, histological studies were conducted on a full-thickness skin wound in rats covered with the SF/CMCS hydrogel, with results indicating that this hydrogel can promote wound re-epithelization and enhance granulation tissue formation. These results illustrate the feasibility of using the developed strategy for SF-based hydrogel fabrication in practice for wound dressing.

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“…The implantation of airway devices is associated with an increase in microbiological colonisation [29,30]. It has been hypothesised that micro-organism presence at the site of implantation leads to a more severe or persistent tissue response upon device implantation causing significant granulation tissue formation [22,27]. Two studies described a correlation between granulation tissue formation after airway stenting and airway colonisation [31,32].…”

Section: Micro-organism Presencementioning

confidence: 99%

“…Host response to device implantation Implantation of any medical device causes some degree of injury to the local tissue [22]. Following this injury, an interaction between the host immune system and the implanted device will occur.…”

Section: Introductionmentioning

confidence: 99%

Airway granulation response to lung-implantable medical devices: a concise overview

2021

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Increasing numbers of endoscopically implantable devices are implanted in the airways, such as airway stents, one-way valves and coils, to treat both malignant and benign diseases. They significantly improve patient outcomes, but their long-term effectiveness and sustainability is hampered by the reaction of the formation of granulation tissue. Factors including procedural-related tissue injury; micro-organism presence; device-related factors, such as the material, design and sizing in relation to the airway; and patient-related factors, including genetic susceptibility, comorbidities and medication use, might all effect the severity of the tissue response and the subsequent degree of granulation tissue formation. However, research into the underlying mechanism and risk factors is scarce and therefore our knowledge is limited. Joint efforts from the scientific community, both pre-clinical and clinical, are needed to gain a deeper understanding and eventually improve the long-term treatment effectiveness of lung-implantable devices.

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Fibrotic Response to Biomaterials and all Associated Sequence of Fibrosis

Cited by 23 publications

References 296 publications

Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor

Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor

Preparation of Silk Fibroin/Carboxymethyl Chitosan Hydrogel under Low Voltage as a Wound Dressing

Airway granulation response to lung-implantable medical devices: a concise overview

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