Fibrous Dysplasia

Parekh, Selene G.; Donthineni-Rao, Rakesh; Ricchetti, Eric T.; Lackman, Richard D.

doi:10.5435/00124635-200409000-00005

Cited by 134 publications

(127 citation statements)

References 32 publications

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“…The etiology of the tumor remains unclear, but fibrous dysplasia appears to be linked to a single nucleotide mutation in the G s α gene on the long arm of chromosome 20 (at 20q13.2-3) that results in a disturbance of the tissue differentiation process [5,6,17]. This mutation occurs in somatic cells sometime after fertilization and therefore is not inherited [17,19].…”

Section: Discussionmentioning

confidence: 99%

“…3 Fibrous dysplasia of the distal radius following curettage. The mass was light tan in color, rubbery in texture, and was easily removed as an intact single large mass They are typically said to have a "ground-glass" appearance, but depending on the extent of the dysplastic fibrous tissue and on the amount of bone and degree of calcification, they may range from radiolucent to sclerotic [2,7,17]. Radiographically, the differential diagnosis may include Paget's disease, solitary bone cysts, aneurysmal bone cysts, enchondroma, adamantinoma, low-grade intramedullary osteosarcoma, osteofibrous dysplasia, and giant cell tumor [5,19].…”

Section: Discussionmentioning

confidence: 99%

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Monostotic Fibrous Dysplasia of the Distal Radius Metaphysis: Case Report

Moseley

Friedrich

2011

Hand (New York, N,Y.)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Monostotic Fibrous Dysplasia of the Distal Radius Metaphysis: Case Report

Moseley

Friedrich

2011

Hand (New York, N,Y.)

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“…They sometimes cause cortical erosion, endosteal scalloping, bone expansion, and thinning of the cortex. Sudden appearance of pain associated with swelling in a patient with fibrous dysplasia usually indicates either pathologic fracture or in rare instances malignant transformation [11]. Radiographically, malignant transformation is associated with cortical destruction and an adjacent soft tissue mass [2].…”

Section: Introductionmentioning

confidence: 99%

Locally Aggressive Fibrous Dysplasia Mimicking Malignancy: A Report of Four Cases and Review of the Literature

Muthusamy

Subhawong

Conway

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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“…Monostotic fibrous dysplasia (MFD) is the common manifestation of diseases. It is four times 4 common than PFD, with location being craniofacial bone, proximal femur, and rib. 2,5 In MFD, zygomatico maxillary complex is commonly involved.…”

Section: Introductionmentioning

confidence: 99%

Extensive Craniofacial Fibrous Dysplasia: An Overview

2017

An International Journal Clinical Rhinology

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Introduction: Fibrous dysplasia (FD) is a common benign osseous tumor that may affect the craniofacial skeletal. It is a slowly progressing disease, presenting with swelling and pressure effects on adjacent structure. Epistaxis as presenting symptom is rare. The literatures reviewed rarely mention it.Aim: The aim of this article is to study the clinical presenta tion and management of extensive craniofacial FD along with review of literature, emphasizing ear, nose, and throat/ endocrinal and orthopedic checkup and computer tomo graphy evaluation and related hematological workup. Serum alkaline phosphatase was also done to see its correlation to disease activity. Brief overview of management and its related complication is done.Results: Both patients were presented with 2year history. There was no predisposing factor. Both were from tribal area. They were having slowly progressive nasal obstruction, facial swelling, and proptosis. In Case 1, it was loosening of tooth and facial pain. In Case 2, it was epistaxis which was the presenting complaint of patient. Nasal obstruction, swelling, and epistaxis in teenager male usually suggest angiofibroma. Craniofacial FD may have epistaxis and pain due to cystic degeneration in FD. Both patients had proptosis; however, their vision was normal. Serum alkaline phosphates was marginally raised, thus not signifying active disease. Computed tomography (CT) scan was diagnostic in both cases, with ground glass appear ance. In Case 2, there was cystic degeneration present and CT was useful in diagnosing the disease, to show the extent of lesion and any intracranial extension. Fine needle aspiration cytology was inconclusive and incision biopsy is better to get representative sample. Lateral rhinotomy approach with lip splitting and gingival component gave good exposure. The tumor was totally removed with thin bone at periphery. The tumor was vascular, and bleeding was controlled by anterior nasal packing.

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Fibrous Dysplasia

Cited by 134 publications

References 32 publications

Monostotic Fibrous Dysplasia of the Distal Radius Metaphysis: Case Report

Monostotic Fibrous Dysplasia of the Distal Radius Metaphysis: Case Report

Locally Aggressive Fibrous Dysplasia Mimicking Malignancy: A Report of Four Cases and Review of the Literature

Extensive Craniofacial Fibrous Dysplasia: An Overview

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