Fibrous Dysplasia and Central Giant Cell Granuloma: A Report of Hybrid Lesion with its Review and Hypotheticated Pathogenesis

Kurra, Saritha

doi:10.7860/jcdr/2013/5533.2987

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…[ 1 3 4 5 6 7 8 ] A search of the literature has failed to reveal the simultaneous occurrence of CGCG and FD except two case reports that have the same lesions as our case but with different appearance to our case. [ 5 8 ]…”

Section: Discussionmentioning

confidence: 85%

“…Hybrid lesions comprising CGCG with fibro-osseous component are very rare, with only nine cases reported in the literature so far. [ 1 3 4 5 6 7 8 ] These lesions may sometimes led to a confusion in their diagnosis as many pathologists report them taking into consideration one of the prominent histopathologic feature. These confusions may be because of the small number of cases reported in the literature with uncertain clinical, radiographic and histopathologic features of these lesions.…”

Section: Introductionmentioning

confidence: 99%

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Hybrid lesions comprising central giant cell granuloma and fibrous dysplasia: A diagnostic challenge for pathologist

Jawanda

Narula

Shankari

et al. 2015

J Oral Maxillofac Pathol

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Hybrid lesions are the lesions consisting of association of features from different pathologies. We present a rare case of hybrid lesion with features of central giant cell granuloma (CGCG) and fibrous dysplasia (FD) involving mandible in a 33-year-old male. Hybrid lesions consisting of features of both benign fibro-osseous lesions and CGCG are very rare. Thus, the purpose of this paper is not only to present a rare case of hybrid lesion with features of CGCG and FD but also to emphasize on the need of careful clinical, radiological and histopathological examination of each and every tissue. There is an important need to report similar and other such cases, which will lead us to understand the interrelationship between these hybrid lesions in a better way and will further clarify their biologic behavior. This will decrease the incidence of misdiagnosis for such cases and will help in preventing recurrences.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Hybrid lesions comprising central giant cell granuloma and fibrous dysplasia: A diagnostic challenge for pathologist

Jawanda

Narula

Shankari

et al. 2015

J Oral Maxillofac Pathol

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“…These bony trabeculae lacks osteoblastic border and are organised in the fibrous stroma, occupied with giant cells and erythrocytes. 4 …”

Section: Discussionmentioning

confidence: 99%

“…The most challenging issue with FD is regrowth of the lesion after reshaping. 4 Hybrid lesions are referred to those lesions that have distinct features from different pathologies in one lesion concomitantly. In the literature, co-occurrence of CGCG with fibro-osseous lesions such as FD, COF, cementoosseous dysplasia and Paget's disease has been reported.…”

Section: Introductionmentioning

confidence: 99%

Fibrous dysplasia associated with peripheral giant cell granoluma in maxilla in a young patient, a case report of rare hybrid lesion

et al. 2023

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Benign fibro-osseous lesions are a diverse range of entities that have distinct clinical and radiographic features. They can occur as solitary lesions or concomitant with other pathologies as hybrid lesions. Fibrous dysplasia (FD) accompanied by central giant cell granuloma (CGCG), peripheral giant cell granuloma (PGCG) or peripheral ossifying fibroma (POF) as hybrid lesions, is reported very rarely in the literature. Although we were unable to find any reports of FD with PGCG as a hybrid lesion. Fibro-osseous lesions have certain histopathological features in common with PGCG including multinucleated giant cells. Here we report a 28 year old female with a painless, slow growing and pedunculated swelling of the maxilla for 18 months. Differential diagnosis consisted of FD, cemento-ossifying fibroma (COF), chondrosarcoma and probable PGCG considering radiographic and clinical investigations. Histopathologic findings revealed PGCG and FD as a hybrid lesion. The combination of PGCG and FD has not been reported in the literature so far.

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“…A mi eseteink során klinikailag három diagnózis merült fel: a fibrosus dysplasia, az OSG és a cherubismus. Egyes közlemények szerint [11][12][13][14] ritkán a fibrosus dys plasia és az OSG együttes előfordulása (ún. "hibrid laesio") is lehetséges.…”

Section: áBra)unclassified

A cherubismus előfordulása három testvérben

Jákob

Pintér

Kotmayer

et al. 2022

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Összefoglaló. A cherubismus ritka, autoszomális dominánsan öröklődő megbetegedés. A fibroossealis elváltozások csoportjába tartozik. Jellemzője az állcsontok szimmetrikus duzzanata, a típusos radiológiai elváltozások és az SH3BP2-gén mutációja. Szövettanilag nem különül el az óriássejtes granulomától. A csontelváltozások és a fibroticus szövet felszaporodása pubertás előtt kezdődik, ezután stagnálás vagy visszafejlődés következik be. A magyar orvosi irodalomban a szerzők elsőként tárgyalják három testvér kórtörténete alapján a cherubismust. A diagnózist a hasonló klinikai tünetek, a típusos kórlefolyás, a szinte azonos radiológiai kép, a szövettan és a genetikai elváltozások biztosítják. A testvérek és az anya csíravonalában kimutatott azonos mutáció akkor is megfelel egy dominánsan öröklődő szindrómának (például cherubismusnak), ha a betegség az anyában klinikailag nem manifesztálódott, de genetikailag igen. A szerzők összefoglalják a kórkép kezelési lehetőségeit: a sebészi (excochleatio, ,,decountouring”, esetleg reszekció) és a gyógyszeres (biszfoszfonát, kalcitonin, szteroid stb.) terápiát. Egyezik a véleményük azokéval, akik azon az állásponton vannak, hogy a beavatkozásokkal várni kell, és meg kell figyelni a betegeket a várható regresszió miatt. Saját eseteikben csak a növekvő tumorrész excochleatióját végezték, főleg kozmetikai okok és a szövettan biztosítása érdekében. Orv Hetil. 2022; 163(11): 446–452. Summary. Cherubism is a rare autosomal, dominant bone disorder, characterised by symmetrical expansion of the jaws along the typical radiological and genetic (SH3BP2 mutation) features. It belongs to the heterogenous group of fibro-osseous lesions. Its histology is the same as that of giant-cell granuloma. The bone lesions and fibrous tissue expansion increase before puberty and regress thereafter. For the first time in Hungarian medical literature, the authors discuss the condition of cherubism in the case of three siblings. The diagnosis of these three siblings is supported by the clinical, radiological, microscopic and genetic data. In all three, the bone lesions and fibrous tissue expansion increased before puberty and stabilized thereafter. The radiological results and the molecular findings were nearly identical. The identical mutation shown in the germ lines of the three siblings and the mother correspond to a dominantly inherited syndrome (e.g., cherubism) even if the condition did not manifest in the mother. The authors summarize the treatment options of the disease: surgical (excochleation, decountouring, in rare case resection) and drug (bisphosphonate, calcitonin, steroid, etc.) therapy. They agree with those who are of the opinion that interventions should wait and the patients should be observed („wait and see”) for the expected regression. In their own cases, only excochleation of the growing tumor was performed, mainly for cosmetic reasons and to secure the tissue. Orv Hetil. 2022; 163(11): 446–452.

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Fibrous Dysplasia and Central Giant Cell Granuloma: A Report of Hybrid Lesion with its Review and Hypotheticated Pathogenesis

Cited by 6 publications

References 16 publications

Hybrid lesions comprising central giant cell granuloma and fibrous dysplasia: A diagnostic challenge for pathologist

Hybrid lesions comprising central giant cell granuloma and fibrous dysplasia: A diagnostic challenge for pathologist

Fibrous dysplasia associated with peripheral giant cell granoluma in maxilla in a young patient, a case report of rare hybrid lesion

A cherubismus előfordulása három testvérben

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