Fibrous Solitary Tumour of the Liver

Teixeira, Frederico; Perina, André Luis de Freitas; Mendes, Gabriella de Oliveira; Andrade, André Bouzas de; Costa, Fabio Paganini Pereira da

doi:10.1007/s12029-014-9635-6

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…[28] The liver is a rare primary site for SFTs with less than 50 cases reported in the English literature. [7][8][9][10][11][12][13][14][15][16][17][18][19] Patient characteristics associated with hepatic SFTs include a mean age of 55 years at presentation, female sex predilection (2:1), and an average tumor size of 17 cm. [7] Although the vast majority of hepatic SFTs behave in a benign fashion, their unpredictable behavior must be emphasized.…”

Section: Discussionmentioning

confidence: 99%

“…Four of the reported cases in the literature displayed aggressive behavior with distant metastases, with one of the cases having a latency period of 6 years between initial diagnosis and advent of metastatic disease. [7][8][9][10][11][12] Metastatic primary hepatic SFTs are associated with larger tumor size (median size of 28 cm). and higher mitotic activity.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6] The liver is a rare primary site for SFTs with less than 50 cases reported in the English literature. [7][8][9][10][11][12][13][14][15][16][17] Although most cases of SFTs are benign, there have been cases of SFTs with malignant features and metastasis. [18,19] Both clinical and radiographic features are not entirely specific and cannot exclude malignancy.…”

Section: Introductionmentioning

confidence: 99%

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A rare case of primary hepatic solitary fibrous tumor associated with pregnancy

Acosta-Gonzalez

Cho

Rogers

et al. 2016

CRCP

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Purpose: To describe a case of histologically and immunohistochemically confirmed primary hepatic solitary fibrous tumor (SFT) associated with pregnancy. Case report: A 40-year-old Caucasian woman G3P1021 with history of oral contraceptive use and no other known significant past medical history delivered via C-section in November of 2012. Two months post delivery, she noted that her abdomen did not decrease in size and sought medical attention. As part of the work-up, an abdominal MRI revealed a 15.9 cm mass centered in segment 4b of the liver with extension into segments 5 and 8 within the right lobe. In addition, an exophytic component extending inferiorly from the liver into the right mid abdomen was noted. The patient underwent an uncomplicated hepatic segmentectomy with cholecystectomy. Grossly, the tumor consisted of a firm tan-white well-circumscribed and partially encapsulated mass. Histologically, the tumor was composed of cytologically bland spindle cells with a patternless architecture with hypocellular and hypercellular areas embedded within a collagenous fibrous stroma with occasional dilated branching thin-walled blood vessels. The tumor showed no infiltrative margins or necrosis and a mitotic count of 1/10HPF. Tumor cells were strongly and diffusely positive for CD34, BCL-2, and vimentin; weakly positive for STAT6 (nuclear distribution); and focally positive for CD99 and β-Catenin. In addition, estrogen and progesterone receptors (ER and PR) were also performed and showed positive staining. The diagnosis of SFT was confirmed. To date, 36 months post-resection, our patient has been followed with imaging, showing no evidence of residual or recurrent disease. Conclusions: Primary hepatic SFT is exceedingly rare and even more so in association with pregnancy. Positive immunohistochemical staining of tumor cells for progesterone and estrogen receptors may indicate hormonal stimulation as a driver of neoplastic cell proliferation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A rare case of primary hepatic solitary fibrous tumor associated with pregnancy

Acosta-Gonzalez

Cho

Rogers

et al. 2016

CRCP

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Tumors of the Liver

Albores‐Saavedra

Henson

Klimstra

2020

Oncological Surgical Pathology

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Solitary fibrous tumour of the liver—report on metastasis and local recurrence of a malignant case and review of literature

Chen

Slater

2017

World J Surg Onc

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BackgroundSolitary fibrous tumours (SFT) are neoplasms of mesenchymal origin that predominantly arise from the pleura. SFT of the liver (SFTL) are a rare occurrence with little number of cases reported in English literature. Malignant cases of hepatic SFT are an even rarer occurrence. For this reason, the prognostic evaluation of SFTLs is unknown and difficult to measure.MethodsA search on English literature on “Solitary Fibrous Tumour of the Liver” was conducted on common search engines (PubMed, Google). All published articles, case reports and literature reviews and their reference lists were reviewed.Case reportThis paper presents a 61-year-old male who was referred to a tertiary hospital in April 2010 with marked hepatomegaly. USS, CT and MRI scans were suggestive of a neoplasm, and the patient underwent a subsegmental IVb resection in June 2010. The specimen demonstrated histological and immunohistochemical features of malignant SFTL with clear resection margins. The patient was followed up regularly for 3 years with imaging and no suggestion of recurrence. Six years after the initial surgery, the patient represented with worsening right upper quadrant pain and dyspnoea secondary to extensive tumour recurrence adjacent to the resection site and metastatic deposits in the pleura. The patient was managed symptomatically and discharged for community follow-up after palliative involvement.ConclusionsSFTL are rare with only 84 cases reported in the English Literature including the present case. The average age of patients is 57.1 and occurs in females more than males (1.4:1). Most SFTLs follow a benign course, however, 17.9% of cases displayed malignant histological features. Only three cases including the current case are reported to have both local recurrence and metastasis. Surgical resection remains the mainstay of treatment and appears to be curative of most cases. The rarity of this tumour makes it difficult to evaluate its prognosis and natural course.

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Fibrous Solitary Tumour of the Liver

Cited by 5 publications

References 4 publications

A rare case of primary hepatic solitary fibrous tumor associated with pregnancy

A rare case of primary hepatic solitary fibrous tumor associated with pregnancy

Tumors of the Liver

Solitary fibrous tumour of the liver—report on metastasis and local recurrence of a malignant case and review of literature

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