Background: To compare the clinical/functional outcomes of supramalleolar osteotomy (SMOT) and ankle arthrodesis (AA) for the treatment of modified Takakura stage 3B ankle osteoarthritis. Methods: Outcomes of 28 SMOT patients and 30 AA patients were reviewed at an average of 50 and 51 months, respectively. The baseline characteristics of the 2 groups were similar. The preoperative tibial articular surface angle and talar tilt angle in the SMOT group were 82.6 and 10 degrees and in the AA group, 83.9 and 9.1 degrees, respectively. The American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot score, visual analog scale (VAS) score, 12-item Short-Form Health Survey (SF-12) mental component summary (MCS) and physical component summary (PCS) scores, range of motion (ROM), radiologic parameters, and complications were compared. Results: The AOFAS, VAS, and SF-12 MCS and PCS scores improved significantly postoperatively in both groups ( P < .001). The VAS and SF-12 PCS scores indicate marginally better improvement in the AA group ( P < .05). The patient satisfaction value ( P = .028) and the possibility of repeated surgery value ( P = .012) were also significantly higher in the AA group. The early ( P = .905) and late ( P = .181) complications did not significantly differ between the 2 groups. The reoperation rate was significantly higher in the SMOT group ( P = .038). Conclusion: Both SMOT and AA showed improvements in function, pain, alignment, and quality of life after surgery. Patients in the AA group reported better pain relief, had a lower reoperation rate, and better hindfoot alignment during a short- to mid-term follow-up time. Level of Evidence: Level III, retrospective comparative study.