2023
DOI: 10.1002/iid3.846
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Fibulin‐2: A potential regulator of immune dysfunction after bone trauma

Abstract: Objectives To reveal the relationship between the fibulin‐2 protein and immune dysfunction after bone trauma. Methods Individuals who were admitted to the study were divided into a bone trauma group, a recovered from bone trauma group and a volunteer without bone trauma group based on the reason for admission. Fibulin‐2 levels in the three groups were compared. Fibulin‐2‐knockout (fibulin‐2−/−) mice and wild‐type (WT) mice were used to detect susceptibility to infection. Hematoxylin and eosin (HE) staining and… Show more

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Cited by 2 publications
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“…For its part, fibulin-2 deficiency also has no effect on normal mice development, likely due to fibulin-1 functional overlapping [21,56]. Yet, these mice showed important differences in recovery from several malignancies like myocardial infarction and bone fracture [54,57]. In the latest participation of fibulin-2 acts by modulation of the inflammatory response; levels of inflammatory cells are significantly lower in the spleen and thymus in fibulin-2 -/animals.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…For its part, fibulin-2 deficiency also has no effect on normal mice development, likely due to fibulin-1 functional overlapping [21,56]. Yet, these mice showed important differences in recovery from several malignancies like myocardial infarction and bone fracture [54,57]. In the latest participation of fibulin-2 acts by modulation of the inflammatory response; levels of inflammatory cells are significantly lower in the spleen and thymus in fibulin-2 -/animals.…”
Section: Discussionmentioning
confidence: 99%
“…In the latest participation of fibulin-2 acts by modulation of the inflammatory response; levels of inflammatory cells are significantly lower in the spleen and thymus in fibulin-2 -/animals. Furthermore, fibulin-2 seems to act also as an inhibitor of BMSCs osteogenesis through inhibition of the Notch2 pathway [57,58].…”
Section: Discussionmentioning
confidence: 99%