Fibulin-5 (FBLN5) gene polymorphism is associated with pelvic organ prolapse

Khadzhieva, Maryam B.; Камоева, С В; Chumachenko, A. G.; Иванова, А. В.; Volodin, I.V.; Vladimirov, Ivan S.; Абилев, С. К.; Salnikova, Lyubov E.

doi:10.1016/j.maturitas.2014.05.003

Cited by 28 publications

(13 citation statements)

References 34 publications

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“…The findings in this paper may be intuitive to many the influence of acquired factors (particularly childbirth) are more likely to be important than genetic or epigenetic considerations in females. Yet this conclusion is at odds with some of the previous findings relating to Fibulin-5 in female pelvic ligaments, as the authors allude to, and is also discrepant with a recent study on Fibulin-5 genetic polymorphisms in females with advanced pelvic organ prolapse [2].…”

contrasting

confidence: 76%

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Colorectal Disease

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Colorectal Disease

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“…The FBLN5 gene rs929608 variation (IVS10-45 A>G) is located in intron 10 (27). Khadzhieva et al (28) showed no association between the FBLN5 rs929608 (T>C) variation and pelvic organ prolapse. Random Forests analysis ranking is found 3 for rs929608 in prostate cancer aggressiveness and Lin et al (29) suggested that FBLN5 gene variation can influence this disease.…”

Section: Discussionmentioning

confidence: 96%

The Sequencing of the Insulin-like Growth Factor 1 and Fibulin 5 Gene Variants in the Pre and Post-menopausal Women with Stress Urinary Incontinence

Pençe¹,

Alsaadoni²,

Çaykara³

et al. 2019

eamr

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Objective: Urinary incontinence (UI) is defined as a social problem via involuntary incontinence. Genetic variations that occur especially in muscle and connective tissue can cause the susceptibility stress type UI. We aimed to investigate the variations in insulin-like growth factor 1 and Fibulin 5 (FBLN5) genes in the pre and postmenopausal women with stress UI (SUI). Methods: The study consisted of 4 groups: 43 premenopausal women with SUI, 30 premenopausal women without SUI, 43 postmenopausal women with SUI and 30 postmenopausal women without SUI. DNA was isolated from blood samples and sequenced with Illumina®MiSeq. The results were analyzed with SPSS22 (IBM Corp., Armonk, NY, USA) and p value less than 0.05 was considered as statistically significant. Results: The A>G variant of rs6214 was found 5.26% (2/38) in the patient group and 0% (0/30) in the control group of the premenopausal group (p>0.05). This variant was found 2.44% (1/41) in the postmenopausal SUI group (p>0.05). The FBLN5 rs929608 variant was not found in any group. Conclusion: No significant association was found between UI and these variants.

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“…Changes in blood concentrations of fibulins have been reported in numerous clinical settings, including in patients with intracerebral hemorrhage, chronic obstructive pulmonary disease, aortic aneurysm, peripheral vascular disease, demyelinating neuropathy, acute pulmonary embolism, malignancies, and pelvic organ prolapse. [25][26][27][28][29] The presence of any of these conditions in a patient with acute chest pain may influence the diagnostic potential of fibulins. Therefore, our findings have to be interpreted with caution.…”

Section: What's New?mentioning

confidence: 99%

Fibulin‑1 and fibulin‑5 as rule‑out tests for non–ST‑elevation myocardial infarction in the emergency setting

Zencir

Sivri

Gülaştı³

et al. 2019

Kardiol Pol

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BACKGROUND Fibulin-1 and fibulin-5 are extracellular glycoproteins from the fibulin family. Both are expressed in the vessel wall and protect against vascular damage. AIMS We aimed to investigate whether fibulin-1 and-5 may be used to exclude non-ST-segment elevation myocardial infarction (NSTEMI) in the emergency setting. METHODS The study included 48 patients in the NSTEMI group and 42 controls who presented with chest pain of noncardiac origin as confirmed by a comprehensive evaluation including coronary angiography. Blood samples for fibulin-1, fibulin-5, and troponin I measurements were drawn on admission to the emergency department. RESULTS Demographic characteristics were similar in patients with NSTEMI and controls. The median levels of both glycoproteins were lower in patients with NSTEMI as compared with controls: fibulin-1, 96.9 µg/ml (interquartile range [IQR], 20-503 µg/ml) vs 111.5 (IQR, 71-457 µg/ml), P = 0.01, and fibulin-5, 38 ng/ml (IQR, 15-509 ng/ml vs 57 ng/ml (IQR, 26-631 ng/ml), P <0.001. The receiver operating characteristic curve analysis revealed the cutoff value of 105.6 µg/ml for fibulin-1 and of 49.4 ng/ml for fibulin-5 to exclude NSTEMI on admission. CONCLUSIONS The present study demonstrated that fibulin-1 and-5 measurements might be used to exclude NSTEMI in patients admitted to the emergency department with acute chest pain.

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Fibulin-5 (FBLN5) gene polymorphism is associated with pelvic organ prolapse

Cited by 28 publications

References 34 publications

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The Sequencing of the Insulin-like Growth Factor 1 and Fibulin 5 Gene Variants in the Pre and Post-menopausal Women with Stress Urinary Incontinence

Fibulin‑1 and fibulin‑5 as rule‑out tests for non–ST‑elevation myocardial infarction in the emergency setting

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