Fibulin Protein Expression in Mid-dermal Elastolysis and Anetoderma: A Study of 23 Cases

Gambichler, Thilo; Reininghaus, L; Skrygan, Marina; Schulze, Hans‐Joachim; Schaller, Jörg; Colato, Chiara; Girolomoni, Giampiero

doi:10.2340/00015555-2340

Cited by 15 publications

(25 citation statements)

References 13 publications

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“…We have recently demonstrated that the expression of fibulin‐4 and fibulin‐5 is significantly reduced in MDE when compared with healthy controls . The fibulin family of extracellular matrix/matricellular proteins is composed of long and short fibulins, which may bind the monomeric form of elastin (tropoelastin) and are involved in various aspects of elastic fibre development .…”

mentioning

confidence: 99%

Lysyl oxidase-like 2 promoter hypermethylation in mid-dermal elastolysis

et al. 2016

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mentioning

confidence: 99%

Lysyl oxidase-like 2 promoter hypermethylation in mid-dermal elastolysis

et al. 2016

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“…Reactive fibroblasts seem to contribute to an MMP-2 rich dermal microenviroment and do not seem to involve MMP-9 secretion in anetoderma. Recently, Gambichler et al observed decreased fibulin-4 expression in patients with anetoderma or MDE, whereas decreased fibulin-5 expression was only observed in patients with MDE [21]. …”

Section: Discussionmentioning

confidence: 99%

A Clinicoimmunohistopathologic Study of Anetoderma: Is Protruding Type More Advanced in Stage Than Indented Type?

Kim

Sohn

Woo

et al. 2016

Journal of Immunology Research

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Background. The clinical and histopathologic classification of anetoderma are not well characterized. Objective. We aimed to investigate the clinical and histopathologic characteristics of anetoderma and to correlate clinical phenotypes with immunohistopathologic findings. Methods. We retrospectively reviewed the medical records of 30 patients with anetoderma and performed immunohistochemistry for elastin, fibrillin-1, metalloproteinase- (MMP-) 2, MMP-7, MMP-9, and MMP-12, and tissue inhibitor of metalloproteinase- (TIMP-) 1 and TIMP-2. Results. Protruding type (n = 17) had a longer disease duration and more severe loss of elastin, without changes in fibrillin, than indented type (n = 13). MMP-2 and MMP-9 showed significantly higher expressions in the dermis compared with controls (p < 0.05). MMP-7 and MMP-12 showed little expressions in both anetoderma and control tissue. TIMP-1 was highly expressed in anetoderma lesions and controls. TIMP-2 expression was variable. Conclusions. Our findings suggest that protruding type anetoderma may represent a more advanced stage and that MMP-2 and MMP-9 could be responsible for elastic fiber degradation in anetoderma.

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“…Inflammatory infiltration is usually scarce or absent; giant cells and obvious elastophagocytosis are uncommon findings . There is evidence of an imbalance between proteolytic metalloproteases (MMPs) and their inhibitors (TIMPs) . Immunohistologically, MDE reveals reduced expression of fibulin‐4 and ‐5, two proteins that are critical for elastic fiber assembly.…”

Section: Mid‐dermal Elastolysismentioning

confidence: 99%