Fiducial-Based Translational Localization Accuracy of Electromagnetic Tracking System and On-Board Kilovoltage Imaging System

Santanam, Lakshmi; Malinowski, K; Hubenshmidt, James; Dimmer, Steve; Mayse, Martin L.; Bradley, Jeffrey D.; Chaudhari, Amir; Lechleiter, Kristen; Goddu, S; Esthappan, Jacqueline; Mutic, Sasa; Low, Daniel A.; Parikh, Parag J.

doi:10.1016/j.ijrobp.2007.10.005

Cited by 41 publications

(49 citation statements)

References 25 publications

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“…It uses 2D X-ray images to accurately estimate the 3D target position at 5-10 Hz during the treatment delivery [18]. The Calypso® system uses implanted electromagnetic transponder-based markers [19] to report the position at 10 Hz. Each patient had three implanted markers.…”

Section: Patient Cohortmentioning

confidence: 99%

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Quantification of intrafraction prostate motion and its dosimetric effect on VMAT

Juneja

Colvill

Kneebone

et al. 2017

Australas Phys Eng Sci Med

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Compliance with ethical standards Conflict of interestRoyal North Shore Hospital has a collaborative research agreement with Varian Medical Systems to support Calypso® and Kilovoltage intrafraction monitoring (KIM) clinical trials. PK holds part ownership of the patent, between Stanford University and Varian Medical Systems, on KIM technology. Ethical approvalAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.Intrafraction prostate motion degrades the accuracy of radiation therapy (RT) delivery. Whilst a number of metrics in the literature have been used to quantify intrafraction prostate motion, it has not been established whether these metrics reflect the effect of motion on the RT dose delivered to the patients. In this study, prostate motion during volumetric modulated arc therapy (VMAT) treatment of 18 patients and a total of 294 fractions was quantified through novel metrics as well as those available in the literature. The impact of the motion on VMAT dosimetry was evaluated using these metrics and dose reconstructions based on a previously validated and published method. The dosimetric impact of the motion on planning target volume (PTV) and clinical target volume (CTV) coverage and organs at risk (OARs) was correlated with the motion metrics, using the coefficient of determination (R 2 ), to evaluate their utility. Action level threshold for the prostate motion metric that best described the dosimetric impact on the PTV D95% was investigated through iterative regression analysis. The average (range) of the mean motion for the patient cohort was 1.5 mm (0.3-9.9 mm). A number of motion metrics were found to be strongly correlated with PTV D95%, the range of R 2 was 0.43-0.81. For all the motion measures, correlations with CTV D99% (range of R 2 was 0.12-0.62), rectum V65% (range of R 2 was 0.33-0.58) and bladder V65% (range of R 2 was 0.51-0.69) were not as strong as for PTV D95%. The mean of the highest 50% of motion metric was one of the best indicator of dosimetric impact on PTV D95%. Action level threshold value for this metric was found to be 3.0 mm. For an individual fraction, when the metric value was greater than 3.0 mm then the PTV D95% was reduced on average by 6.2%. This study demonstrated that several motion metrics are well correlated with the dosimetric impact (PTV D95%) of individual fraction prostate motion on VMAT delivery and could be used for treatment course adaptation.

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Section: Patient Cohortmentioning

confidence: 99%

“…Each patient had three implanted markers. Both the KIM [9,15] and Calypso® [19] systems have been reported to have sub-millimetre accuracy. In both trials, the motion of the centroid of the implanted markers, with no corrections, was used as a surrogate for intrafraction prostate motion.…”

Section: Patient Cohortmentioning

confidence: 99%

Quantification of intrafraction prostate motion and its dosimetric effect on VMAT

Juneja

Colvill

Kneebone

et al. 2017

Australas Phys Eng Sci Med

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“…Patient and animal studies have also demonstrated strong correlation between transponder‐based systems and radiographic systems 5, 11, 13, 15, 16, 17, 18. Foster et al 15.…”

Section: Introductionmentioning

confidence: 99%

“…Other authors have compared transponder‐based systems with radiographic imaging in phantom studies 11, 12, 13, 14. Santanam et al.…”

Section: Introductionmentioning

confidence: 99%

Comparison between electromagnetic transponders and radiographic imaging for prostate localization: A pelvic phantom study with rotations and translations

Hamilton

McKenzie

Perkins

2017

J Applied Clin Med Phys

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The aim of this study was to evaluate the differences in target localization between Calypso®, kV orthogonal imaging and cone‐beam computed tomography (CBCT) for combined translations and rotations of an anthropomorphic pelvic phantom. The phantom was localized using all three systems in 50 different positions, with applied translational and rotational offsets randomly sampled from representative normal distributions of prostate motion. Lin's concordance correlation coefficient (ρc) and 95% confidence intervals were calculated to assess the agreement between the localization systems. Mean differences and difference vectors between the three systems were also calculated. Agreement between systems for lateral, vertical, and longitudinal translations was excellent, with ρc values of greater than 0.98 between all three systems in all axes. There was excellent agreement between the systems for rotations around the lateral axis (pitch) (ρc > 0.99), and around the vertical axis (yaw) (ρc > 0.97). However, somewhat poorer agreement for rotations around the longitudinal axis (roll) was observed, with the lowest correlation observed between Calypso and kV orthogonal imaging (ρc = 0.895). Mean differences between the phantom position reported by Calypso and the radiographic systems were less than 1 mm and 1° for all translations and rotations. The results for translations are consistent with the publications of previous authors. There is no comparable published data for rotations. While there is lower correlation between the three systems for roll than for the other angles, the mean differences in reported rotations are not clinically significant.

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“…Here, a typical patient-specific motion pattern is applied to simulate the motion of the tumor target volume (usually the lung or the liver) during irradiation. The identification of fiducial markers implanted into the tissue neighboring the tumor with planar x-ray imaging [9,10] or the implantation of passive electromagnetic transponders [19] is an alternative method to achieve motion monitoring. The increase in dose delivery precision is, however, accompanied by additional clinical effort and trauma caused by the implantation.…”

Section: Introductionmentioning

confidence: 99%

High-performance GPU-based rendering for real-time, rigid 2D/3D-image registration and motion prediction in radiation oncology

Spoerk

Gendrin

Weber

et al. 2012

Zeitschrift für Medizinische Physik

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A common problem in image-guided radiation therapy (IGRT) of lung cancer as well as other malignant diseases is the compensation of periodic and aperiodic motion during dose delivery. Modern systems for image-guided radiation oncology allow for the acquisition of cone-beam computed tomography data in the treatment room as well as the acquisition of planar radiographs during the treatment. A mid-term research goal is the compensation of tumor target volume motion by 2D/3D registration. In 2D/3D registration, spatial information on organ location is derived by an iterative comparison of perspective volume renderings, so-called digitally rendered radiographs (DRR) from computed tomography volume data, and planar reference x-rays. Currently, this rendering process is very time consuming, and real-time registration, which should at least provide data on organ position in less than a second, has not come into existence. We present two GPU-based rendering algorithms which generate a DRR of 512 × 512 pixels size from a CT dataset of 53 MB size at a pace of almost 100 Hz. This rendering rate is feasible by applying a number of algorithmic simplifications which range from alternative volume-driven rendering approaches -namely so-called wobbled splatting -to sub-sampling of the DRR-image by means of specialized raycasting techniques. Furthermore, general purpose graphics processing unit (GPGPU) programming paradigms were consequently utilized. Rendering quality and performance as well as the influence on the quality and performance of the overall registration process were measured and analyzed in detail. The results show that both methods are competitive and pave the way for fast motion compensation by rigid and possibly even non-rigid 2D/3D registration and, beyond that, adaptive filtering of motion models in IGRT.

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Fiducial-Based Translational Localization Accuracy of Electromagnetic Tracking System and On-Board Kilovoltage Imaging System

Cited by 41 publications

References 25 publications

Quantification of intrafraction prostate motion and its dosimetric effect on VMAT

Quantification of intrafraction prostate motion and its dosimetric effect on VMAT

Comparison between electromagnetic transponders and radiographic imaging for prostate localization: A pelvic phantom study with rotations and translations

High-performance GPU-based rendering for real-time, rigid 2D/3D-image registration and motion prediction in radiation oncology

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