Residential solid fuel combustion significantly impacts air quality and human health. Pelletized biomass fuels are promoted as a cleaner alternative, particularly for those who cannot afford the high costs of gas/electricity, but their emission characteristics and potential effects remain poorly understood. The present laboratory-based study evaluated pollution emissions from pelletized biomass burning, including CH 4 (methane), NMHC (nonmethane hydrocarbon compounds), CO, SO 2 , NO x , PM 2.5 (particulate matter with an aerodynamic diameter ≤2.5 μm), OC (organic carbon), EC (element carbon), PAHs (polycyclic aromatic hydrocarbons), EPFRs (environmentally persistent free radicals), and OP (oxidative potential) of PM 2.5 , and compared with those from raw biomass burning. For most targets, except for SO 2 and NO x , the mass-based emission factors for pelletized biomass were 62−96% lower than those for raw biomass. SO 2 and NO x levels were negatively correlated with other air pollutants (p < 0.05). Based on real-world daily consumption data, this study estimated that households using pelletized biomass could achieve significant reductions (51−95%) in emissions of CH 4 , NMHC, CO, PM 2.5 , OC, EC, PAHs, and EPFRs compared to those using raw biomass, while the differences in emissions of NO x and SO 2 were statistically insignificant. The reduction rate of benzo(a)pyreneequivalent emissions was only 16%, much lower than the reduction in the total PAH mass (78%). This is primarily attributed to the more PAHs with high toxic potentials, such as dibenz(a,h)anthracene, in the pelletized biomass emissions. Consequently, impacts on human health associated with PAHs might be overestimated if only the mass of total PAHs was counted. The OP of particles from the pellet burning was also significantly lower than that from raw biomass by 96%. The results suggested that pelletized biomass could be a transitional substitution option that can significantly improve air quality and mitigate human exposure.