Field-effect transistor with a chemically synthesized MoS2 sensing channel for label-free and highly sensitive electrical detection of DNA hybridization

Lee, Doowon; Lee, Sung Yong; Sohn, Il Yung; Kim, Bo‐Yeong; Son, Young Min; Bark, Hunyoung; Jung, Jaehyuck; Choi, Minseok; Kim, Tae Hyeong; Lee, Changgu; Lee, Nae‐Eung

doi:10.1007/s12274-015-0744-8

Cited by 123 publications

(95 citation statements)

References 55 publications

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“…To decrease the vaporization influence of the metal precursor, it is possible to pre-deposit a transition-metal (TM) or transition-metal oxide (TMO) on a substrate with subsequent sulfurization from a S source. [9][10][11][12][13] The homogeneous S supply can also be achieved by using a gaseous precursor such as H 2 S. [14][15][16][17][18][19][20][21] The present paper elucidates the mechanisms of MoS 2 multilayer synthesis by the sulfurization technique. The influence of the process temperature, annealing time, and ramp rate is studied, as well as the nature of the pre-deposited layers MoO 3 , metallic Mo, and the nature of the substrate.…”

Section: Introductionmentioning

confidence: 95%

Multilayer MoS₂ growth by metal and metal oxide sulfurization

et al. 2016

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Section: Introductionmentioning

confidence: 95%

Multilayer MoS₂ growth by metal and metal oxide sulfurization

et al. 2016

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“…The results also improve by several orders of magnitude those obtained by traditional methods such as the enzyme‐linked immunosorbent assay and are similar to recent nanosensors with a more complicated fabrication process, offering a promising alternative for fast and low‐cost delivery and use in emergency situations or in remote areas. Comparable detection levels as well as sensing areas ( Table 1 ) were obtained by other recent electrical biosensors based on MoS 2 with more complex fabrication methodology, not flexible, or not tested down to such low bending radius (1 mm) . The biosensor also shows remarkable performance with similar or better limit of detection compared to other Ebola detection techniques, showing no particular drawbacks such as necessity of special safety facilities, labeling, or difficulties for miniaturization (see Table S2, Supporting Information).…”

Section: Resultsmentioning

confidence: 57%

Electrochemically Exfoliated High‐Quality 2H‐MoS₂ for Multiflake Thin Film Flexible Biosensors

Zhang

Yang

Pineda‐Gómez

et al. 2019

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transition metal dichalcogenides (TMDs), which present indirect bandgaps in the range of 1.0-2.0 eV and are suitable for electronic devices. [1] Molybdenum disulfide (MoS 2 ) is the one of the most explored TMDs, ideal for new generation electronics, [2] optoelectronics, [3] and topological insulators. [4] Several examples of applications can be found where MoS 2 thin films are used, such as sensors, [5] energy storage, [6] or flexible electronics. [7] Thus, a method to prepare highly concentrated and stable dispersions of excellent quality semiconducting TMDs materials is essential in order to achieve solutionprocessed, inexpensive, large area high performance devices.However, exfoliated MoS 2 flakes exhibit heterogeneous properties, depending on their thickness, lattice structures as well as chemical composition. The synthetic methods are thus critically important, in order to access their intact properties. Considerable progress have been achieved to overcome the weak interlayer interactions to produce mono-or few-layer MoS 2 using micromechanical cleavage, [2,8] chemical intercalation, [9] and ultrasound-promoted shear exfoliation. [10] While micromechanical cleavage is able to obtain pristine MoS 2 flakes with very limited yield, the chemical routes using harsh tert-butylithium-mediated intercalation are able to produce single-layer MoS 2 flakes with large quantity. However, the lithium intercalation converts MoS 2 from pristine semiconducting 2H phase to metallic 1T phase. Beyond that, liquid-phase exfoliation with suitable solvents (e.g., N-methyl-2-pyrrolidone (NMP)) offers macroscopic quantity of 2H-MoS 2 flakes. [11] Nonetheless, it requires long-last agitation (e.g., 23 h) and delivers low exfoliation yields (≈40%) as well as small sheet sizes (less than 1 µm). [12] By now, it remains a great challenge to prepare large sheet size, high-quality 2H-MoS 2 flakes with high yield.Herein, we demonstrated a novel scalable method to prepare high-quality 2H-MoS 2 flakes by cathodic exfoliation in organic electrolyte. Especially, the intercalation of tetra-n-butylammonium cations in bulk MoS 2 benefits to fast exfoliation within 1 h, high yield of 70% and large-sized flakes up to 50 µm. The method is appealing to obtain high quality multiflake films with no throughput limitations for the variety of electronic applications abovementioned. As a first application, we fabricated the large-area biosensor, developed by a restacking the 2H-MoS 2 flakes into thin film on the flexible polyimide 2D molybdenum disulfide (MoS 2 ) gives a new inspiration for the field of nanoelectronics, photovoltaics, and sensorics. However, the most common processing technology, e.g., liquid-phase based scalable exfoliation used for device fabrication, leads to the number of shortcomings that impede their large area production and integration. Major challenges are associated with the small size and low concentration of MoS 2 flakes, as well as insufficient control over their physical properties, e.g., internal heterogeneity of the metal...

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“…Recently, Duan et al developed a few‐layer MoS 2 ‐nanosheet‐based FET for Hg 2+ detection, showing a detection limit as low as 30 pM . For sensing biomolecules, FET biosensors have been widely investigated in view of their high sensitivity, label‐free detection ability, low power consumption, and compatibility with commercial planar processes for large‐scale production . For example, Sarkar et al fabricated a MoS 2 ‐nanosheet‐based FET biosensor for detection of streptavidin .…”

Section: Tmd Nanosheets and Their Composite‐based Electronic Sensorsmentioning

confidence: 99%

Recent Advances in Sensing Applications of Two‐Dimensional Transition Metal Dichalcogenide Nanosheets and Their Composites

Ping

Fan

Sindoro

et al. 2017

Adv Funct Materials

244

136

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of 18) 1605817As a newly emerging class of nanomaterials, 2D TMD nanosheets possess a unique layered structure and large surface areas, as well as outstanding physical, chemical, optical, and electronic properties, which holds great potential for applications in catalysis, [37] sensing, [38] optics, [39] and energy. [40] In this review, we will focus on the introduction of state of the art sensing applications for 2D TMD nanosheets and their composites. In particular, different sensing strategies together with signal-transducing mechanisms in sensors based on 2D TMD nanosheets and their composites are thoroughly discussed. Our aim is to demonstrate a complete concept in this rapidly emerging research area and to address basic knowledge, opportunities, and challenges in this promising field. We expect that more 2D TMD nanosheets and their composites, as well as more sensing strategies, will be explored in this research field, enabling the fabrication of more accurate sensing devices for practical applications. TMD Nanosheets and Their Composite-Based Electrochemical SensorsThe electrochemical method has been extensively recognized as a powerful tool for fast access to biochemical information in complex samples due to its easy operation, fast response, high sensitivity, and low cost. Inspired by the use of graphene as transducers in electrochemical sensors, [41][42][43] researchers have attempted to use 2D TMD nanosheets as a transducer layer. Their good conductivity, large surface area, fast electron transfer kinetics, high signal/noise ratio, and, more importantly, their feasibility for forming composites, make 2D TMD nanosheets attractive as for electrochemical sensors. [44][45][46][47][48][49][50] Table 1 summarizes the recent progress of electrochemical sensors based on 2D TMD nanosheets and their composites. TMD Nanosheets as a Transducer Layer in Electrochemical SensorsIn 2012, our group developed a single-layer TMD-nanosheetbased electrochemical sensor, in which a single-layer MoS 2nanosheet-modified glassy carbon electrode was directly used for selective detection of dopamine in the presence of uric acid Two-dimensional (2D) transition metal dichalcogenide (TMD) nanosheets, such as MoS 2 , WS 2 , etc., are attracting increasing interest due to their intriguing physical, chemical, electronic, and optical properties. Success in development of methods for large-scale production of 2D TMD nanosheets and their composites has given great potential for various novel applications. In this review, recent progress in sensing applications of 2D TMD nanosheets and their composites is introduced. Moreover, different sensing strategies and signal-transducing mechanisms for sensing devices based on 2D TMD nanosheets and their composites are also summarized and discussed.

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Field-effect transistor with a chemically synthesized MoS2 sensing channel for label-free and highly sensitive electrical detection of DNA hybridization

Cited by 123 publications

References 55 publications

Multilayer MoS₂ growth by metal and metal oxide sulfurization

Multilayer MoS₂ growth by metal and metal oxide sulfurization

Electrochemically Exfoliated High‐Quality 2H‐MoS₂ for Multiflake Thin Film Flexible Biosensors

Recent Advances in Sensing Applications of Two‐Dimensional Transition Metal Dichalcogenide Nanosheets and Their Composites

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Field-effect transistor with a chemically synthesized MoS2 sensing channel for label-free and highly sensitive electrical detection of DNA hybridization

Cited by 123 publications

References 55 publications

Multilayer MoS2 growth by metal and metal oxide sulfurization

Multilayer MoS2 growth by metal and metal oxide sulfurization

Electrochemically Exfoliated High‐Quality 2H‐MoS2 for Multiflake Thin Film Flexible Biosensors

Recent Advances in Sensing Applications of Two‐Dimensional Transition Metal Dichalcogenide Nanosheets and Their Composites

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Multilayer MoS₂ growth by metal and metal oxide sulfurization

Multilayer MoS₂ growth by metal and metal oxide sulfurization

Electrochemically Exfoliated High‐Quality 2H‐MoS₂ for Multiflake Thin Film Flexible Biosensors