Field efficacy of two netobimin oral suspensions (5% and 15%) in sheep naturally infected with Dicrocoelium dendriticum

Şenlik, Bayram; Çirak, Veli Yılgör; Tinar, Recep

doi:10.1016/j.smallrumres.2008.09.004

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…Thiophanate and netobimin, two compounds that are metabolised to benzimidazole by animals, have also been shown to be effective against small flukes. Netobimin at a dose of 15 mg/kg or 20 mg/kg showed efficacy of 91.9% and 91.5% respectively [19].This study was carried out to compare the efficacy of two suspensions (5% and 15%) of netobimin against Dicrocoelium dendriticum in naturally infected sheep. The efficacy was checked by post-mortem examination twenty-one days post-treatment.…”

Section: Introductionmentioning

confidence: 99%

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Lack of Efficacy of Albenzole Against <em>Dicrocoelium dendriticum</em> Infection in a Sheep Farm in France

Petermann,

Grisez,

Lavigne

et al. 2024

Preprint

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Dicrocoeliosis is a common parasitic disease in European sheep farming. The prevalence of infec-tion by this parasite can reach almost 70% in areas where the environment is favourable to inter-mediate hosts. In France, only one drug is currently available for the treatment of dicrocoeliosis, albendazole at a dose of 15 mg/kg in a single administration. However, a control coproscopy fol-lowing a routine treatment led us to suspect that the efficacy of albendazole against Dicrocoelium dendriticum had diminished. We therefore carried out an efficacy test on 15 animals by treating them with albendazole at a dose of 15 mg/kg and performing a coproscopy on D0 and a control coproscopy 14 days later. We obtained a 38% reduction in the excretion of Dicrocoelium dendriticum eggs. This shows a re-duction in the expected efficacy of albendazole, which is normally more than 90% in other studies involving this molecule at a dosage of 15 mg/kg.

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Section: Introductionmentioning

confidence: 99%

“…The efficacy was checked by post-mortem examination twenty-one days post-treatment. The results showed that the efficacy of 5% and 15% suspension of netobimin was 90.80% and 91.50%, respectively, and the use of 15% suspension in sheep is discussed [19,20]) . Thiophanate showed 74.4% efficacy at a dose of 50mg/kg [18].…”

Section: Introductionmentioning

confidence: 99%

Lack of Efficacy of Albenzole Against <em>Dicrocoelium dendriticum</em> Infection in a Sheep Farm in France

Petermann,

Grisez,

Lavigne

et al. 2024

Preprint

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“…Dicrocoeliosis has been reported in sheep Senlik et al, 2008;Sargison et al, 2012;Bosco et al, 2015), goats (Jithendran and Bhat, 1996;Khanjari et al, 2014), cattle (Colwell and Goater, 2010), buffalo (Rinaldi et al, 2009), deer (Otranto et al, 2007), camels (Wahba et al, 1997), pigs (Capucchio et al, 2009) and llamas (Dadak et al, 2013) in specific ecological niches around the world. This generalist definitive host strategy extends to sympatric rodent (Berry and Tricker, 1969), lagomorph (Sargison et al, 2012) and ungulate (Goater and Colwell, 2007;Beck et al, 2014) wildlife.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of molecular methods for the field study of the natural history of Dicrocoelium dendriticum

Mitchell

Cuthill

Haine

et al. 2017

Veterinary Parasitology

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“…In spite of there being various chemotherapeutic compounds available for treatment of dicrocoeliosis (Rojo-Vazquez et al, 1989;Ambrosi et al, 1995;Otranto and Traversa, 2002;Senlik et al, 2008), none are effective against the juvenile and immature stages of D. dendriticum, or, if they are effective, as is diamphenethide, the dose is high (240 mg/kg: 93-95% efficacy) and serious side effects appear after administration (Stratan, 1986).…”

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confidence: 99%

Strategic control of Dicrocoelium dendriticum (Digenea) egg excretion by naturally infected sheep

Manga-González¹,

Quiróz-Romero²,

González-Lanza³

et al. 2010

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to determine the most appropriate months for applying albendazole (ABZ; oral suspension dose 20 mg/kg body weight) to sheep naturally infected with Dicrocoelium dendriticum and kept at pasture, in order to reduce parasite egg shedding to a minimum, mainly during the cold months and, as a result, decrease pasture contamination by viable eggs. Five animal groups (G), homogeneous as regards the number of eggs per gram (EPG) in faeces, were established. The treatment months were: G1, November and January; G2, November and February; G3, November and April; G4, January; and G5 (control), April. Ten samplings (S1-S10) were carried out every 35 to 45 days to collect faecal samples from the rectum of each animal in the five groups. The sedimentation technique and McMaster egg counting chambers were used to analyze the faecal samples. Due to the effect of albendazole (ABZ) treatments, the five groups behaved differently with regard to EPG reduction and the percentage of samples positive for D. dendriticum eggs. Using the Kruskal-Wallis test, statistically significant differences (P < 0.05) were observed between the EPG values obtained in G5 and the rest of the groups from November to May, but not from May onwards. The biggest reduction in egg excretion was obtained in G1, mainly in the cold period when elimination is highest and egg survival greatest, so G1 gave the best result, followed by G2, G4, G3 and finally G5 in descending order.

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Field efficacy of two netobimin oral suspensions (5% and 15%) in sheep naturally infected with Dicrocoelium dendriticum

Cited by 8 publications

References 9 publications

Lack of Efficacy of Albenzole Against <em>Dicrocoelium dendriticum</em> Infection in a Sheep Farm in France

Lack of Efficacy of Albenzole Against <em>Dicrocoelium dendriticum</em> Infection in a Sheep Farm in France

Evaluation of molecular methods for the field study of the natural history of Dicrocoelium dendriticum

Strategic control of Dicrocoelium dendriticum (Digenea) egg excretion by naturally infected sheep

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