Introduction. In Russia, based on the provisions of the current regulatory documents, the time for the start of evacuation for a room in which a fire broke out is determined depending on the area of the room. According to some authors, the time of the start of the evacuation of people is a combination of “technical”, which includes the time of detection of a fire, and “psychophysical”, determined by the behavioral and organizational characteristics of the people who make it up. The fire detection time is currently not taken into account.Purpose. Evaluation of the influence of the size of the cells of the computational grid and the inhomogeneity of the computational domain on the estimated time of fire detection.Aims. 1. Establish the qualitative nature of the influence of the size of the cells of the computational grid and the inhomogeneity of the computational domain on the estimated time of fire detection.2. Offer recommendations for determining the estimated time of fire detection.Methods. For research, computer simulation methods were used using the Fire Dynamics Simulator software package.Results and discussion. The use of grids with different cell sizes can significantly reduce the number of cells in the computational domain and, as a result, the computation time. However, this leads to rather contradictory results. The minimum time values are reduced by almost 3–4 times compared to a homogeneous computational grid, and the maximum time increases by 2 times.Conclusions. 1. The size of the cells of the computational grid and the inhomogeneity of the computational domain have a significant impact on the time of fire detection.2. A sufficiently large spread in the values of the estimated fire detection time may indicate an unreliable estimate of the total time for the start of evacuation and incorrect conclusions about the safe evacuation of people and/or the probability of evacuation of people.3. For a correct estimate of the evacuation start time, taken into account the estimated fire detection time, it is recommended to use homogeneous computational grids with cell sizes not exceeding 0.25 m.