Field study of the urinary excretion of ethoxyacetic acid during repeated daily exposure to the ethyl ether of ethylene glycol and the ethyl ether of ethylene glycol acetate.

Abstract

13 (1987) 239-242. The urinar y excretion of ethoxyacetic acid (EAA) was stud ied in a gro up of five wome n da ily expo sed to the ethy l ether of ethylene glycol (EGEE) and the ethyl ether of ethylene glycol acetat e (EGEE-A c) dur ing 5 d of nor mal p rodu ctio n a nd 7 d after a 12-d productio n stop . The mean combined exposure conce ntration o f EGEE and EGEE-Ac (expres sed in equ ivalent weight of EGEE) was 14.0 mg/ m ' with occasio nal slight excursion s above the curr ent Belgian occupationa l exposure limit. The daily combined expos ure profiles for EG EE an d EG EE-Ac were rath er cons ta nt dur ing the first observatio n period, but they ten ded to decrease dur ing the last week . The urinar y EAA excretion clear ly increased during the work week . Over the weeke nds the elimination was far from complete, and even afte r a prolonged no nexposur e period of 12 d traces of the metabolite were still detecta ble. Based on the observations from the first period, a goo d linea r correlation (r =0.92) was found between the averag e exposure over 5 d (14.4 mg/ m ' ) and the EAA excretion at the end of the week (105.7 mg/ g creatinine). An EAA estimate of 150 ± 35 mg/ g was fou nd to correspond with repeated 5-d full-shift exposures to the respective occup atio nal exposure limit o f EGEE (19 mg /m') or EGEE-Ac (27 mg/m').

2‐Ethoxyethanol, 2‐Ethoxyethylacetat [MAK Value Documentation in German language, 1994]

“…eines Glycinkonjugates, gefunden (Groeseneken et al 1988). Basierend auf den Daten von Groeseneken et al (1986a, b) und den Beobachtungen von Veulemans et al (1987), daß es bei einer Exposition gegenüber 2-Ethoxyethanol am Arbeitsplatz über die Arbeitswoche zu einer Kumulation der 2-Ethoxyessigsäure im Harn kommt (siehe unten), wurden die resultierenden 2-Ethoxyessigsäure-Konzentrationen im Harn abgeschätzt: Bei einer rein inhalativen Exposition am Arbeitsplatz (8 Stunden/Tag) gegenüber 2-Ethoxyethanol-Konzentrationen in Höhe des bisherigen MAK-Wertes von 20 ml/m 3 (75 mg/m 3 ) ist am Ende der Arbeitswoche,je nach der Höhe der körperlichen Belastung, mit 2-Ethoxyessigsäure-Konzentrationen im Harn zwischen 40 und 140 mg/l zu rechnen (Henschler und Lehnert 1993).…”

“…Der Zusammenhang zwischen einer Exposition am Arbeitsplatz und der 2-Ethoxyessigsäure-Ausscheidung wurde von Veulemans et al (1987) an einer Gruppe von 5 Frauen untersucht, die mit Siebdruckarbeiten beschäftigt waren. Die Arbeiterinnen waren einem Lösungsmittelgemisch ausgesetzt, das u. a.…”

2‐Ethoxyethanol, 2‐Ethoxyethyl acetate [MAK Value Documentation, 1998]

“…On the basis of the data from Groeseneken et al (1986aGroeseneken et al ( , 1986b) and the observations of Veulemans et al (1987) that, after occupational exposure to 2-ethoxyethanol, 2-ethoxyacetic acid accumulates in the urine during the working week (see below), an estimate was made of the resulting 2-ethoxyacetic acid concentrations in the urine: after exposure exclusively by inhalation at the workplace (8 hours/day) to 2-ethoxyethanol concentrations at the level of the previous MAK value of 20 ml/m 3 (75 mg/m 3 to be between 40 and 140 mg/l depending on the level of physical activity (Henschler and Lehnert 1993). (Groeseneken et al 1986a(Groeseneken et al , 1986b(Groeseneken et al , 1988 2-Ethoxyethyl acetate (Groeseneken et al 1987a(Groeseneken et al , 1987b Absorption ( …”

“…The relationship between exposure at the workplace and excretion of 2-ethoxyacetic acid was investigated by Veulemans et al (1987) in a group of 5 women employed in screen printing. The women were exposed to a mixture of solvents containing 2-ethoxyethanol and 2-ethoxyethyl acetate.…”

Ethylene glycol monoethyl ether [MAK Value Documentation, 2008]

“…A value of 110 μmol ethoxyacetic acid/mmol creatinine (95th percentile) in biological material corresponding to about 120 mg/l urine was calculated for 8-hour exposure to EGEE at 18 mg/m 3 (about 5 ml/m 3 ) (Truchon et al 2006; see Table 1). Veulemans et al 1987 workers (n = 30) EGEE A: 12 (2.9-34) 1.3-32 1) Lowry et al 1993 workers in the production of varnishes (n = 12) EGEE:2.8 128.5 (PRS); 167.8 (POS) Angerer et al 1990 EGEE A: 2.7 worker (formulation; n = 19) Friday EGEE: 1.9 EGEE A: 2.2…”