Field study on plasma haptoglobin concentrations and total milk somatic cell counts in cows with untreated and treated mastitis

Georgieva, T. M.; Vasilev, Nasko; Karadaev, Manol; Fasulkov, Ivan; Ceciliani, Fabrizio

doi:10.15547/bjvm.1052

Cited by 2 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This simultaneous elevation in serum concentrations of both SAA and Hp as seen in the current work is in agreement with observations made in several studies on APP in dairy cows. Eckersall in their study on the acute phase proteins in serum from dairy cows with clinical case of mastitis had indicated a significant positive strong correlation between Hp and SAA [72]. In contrast to our findings, however, only serum Hp concentration elevated in mastitis cows as was reported by [81], whereas both SAA and Hp levels have increased extensively PC in our findings.…”

Section: Interleukin 12contrasting

confidence: 92%

“…The current study had indicated that there was a significant increase in Hp concentrations of The findings of the current study are consistent with the reports of [72], who studied the acute phase proteins in serum from dairy cows with clinical case of mastitis, where they concluded that SAA and Hp have both been identified as a major acute phase protein in cattle associated with mastitis infection and that their elevation and detection in serum samples is always a clear indication of acute phase response (APR) to opsonisation, infection or challenge. In a more detailed report by [73] who conducted a study on the early pathogenesis and inflammatory responses in experimental bovine mastitis due to gram positive bacteria stipulated that increased in SAA and Hp is a tool of measuring the severity of mastitis infection in both experimentally and naturally challenged cows in dairy farms.…”

Section: Interleukin 12supporting

confidence: 92%

“…Acute phase proteins constitute part of innate immune components whose concentration varies with respect to stimuli of external or internal origin [71]. APPs concentration such as SAA and Hp increases during early phase of reaction of cows to bacterial challenge or infection [72,73]. These two APPs aid in determining the progress of inflammatory conditions thereby acting as a valuable diagnostic and prognostic tool in cases of mastitis in dairy cows [74,41].…”

Section: Interleukin 12mentioning

confidence: 99%

See 2 more Smart Citations

Acute Phase Proteins (Haptoglobin and Serum Amyloid A) and Pro-Inflammatory Cytokines (IL-12 and IL-10) in Cows Vaccinated with Prototype Killed S. aureus Mastitis Vaccine and Challenged with S. aureus Mastitis Infection.

Hambali

Abdallah

Bhuttu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background The economic downturn experienced by farmers and the fear of milk borne infection are of a greater public health concern. Haptoglobin, Serum Amyloid A, IL-12 and IL-10 in lactating Friesian cows vaccinated with prototype killed S. aureus mastitis vaccine and challenged with S. aureus were evaluated. Bacterin concentration at 10 8 cfu /ml of the local isolate of S. aureus was adjuvanted with KAl(SO₄)₂. Six lactating Friesian cows were grouped into A= Negative control, B = Positive control and C = vaccine group. Group C was vaccinated intramuscularly with 2ml of the monovalent vaccine, groups A and B with physiologic normal saline. Groups B and C were later challenged with the live bacterium via intramammary route . Result There was a significant increase in IL-10 concentration in vaccinated group post primary vaccination (PPV), booster phase (PB) and during the bacterial challenge phase. There was also a significantly increased IL-12 concentration in the vaccinated group at 24 hours, weeks 1 and 2 PPV. Haptoglobin at 12 and 24 hours PPV had a significant difference in group C. During the PB at 8 and 12 hours there was a significant difference in group C. During the bacterial challenged phase at 0, 3, 24 hours and day 7 PC there was a significant difference in group B. At 8 hours PC there was a significant difference in group C. For Serum Amyloid A, during PPV at 0, 3, 8, 12, 24 hours and weeks 1 and 2, the concentrations was significantly different in groups C. During PB at 0, 3, 8 and 12 hours PB there was a significant difference in groups C. During the bacterial challenge phase at 3, 8, 12, 24 hours, days 7 and 14 PC there was a significant difference in group B. At 0 hour PC there was a significant increase observed in group C. Conclusion The developed prototype killed S. aureus mastitis vaccine using local isolates was able to stimulate acute phase proteins and pro-inflammatory cytokines. The pattern of responses PC indicated protection, thereby suggesting that vaccination can protect against mastitis infection in dairy cows.

show abstract

Section: Interleukin 12contrasting

confidence: 92%

Section: Interleukin 12supporting

confidence: 92%

Section: Interleukin 12mentioning

confidence: 99%

See 1 more Smart Citation

Acute Phase Proteins (Haptoglobin and Serum Amyloid A) and Pro-Inflammatory Cytokines (IL-12 and IL-10) in Cows Vaccinated with Prototype Killed S. aureus Mastitis Vaccine and Challenged with S. aureus Mastitis Infection.

Hambali

Abdallah

Bhuttu

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Hp is significantly elevated in milk during mastitis [ 94 ]. Georgieva et al [ 95 ] suggested that the concentration of plasma Hp in the high SCC group (SCM) was approximately six times higher than that in the normal SCC group.…”

Section: Mastitis Diagnosismentioning

confidence: 99%

Basic concepts, recent advances, and future perspectives in the diagnosis of bovine mastitis

Algharib,

Dawood,

Huang

et al. 2024

J Vet Sci

View full text Add to dashboard Cite

Mastitis is one of the most widespread infectious diseases that adversely affects the profitability of the dairy industry worldwide. Accurate diagnosis and identification of pathogens early to cull infected animals and minimize the spread of infection in herds is critical for improving treatment effects and dairy farm welfare. The major pathogens causing mastitis and pathogenesis are assessed first. The most recent and advanced strategies for detecting mastitis, including genomics and proteomics approaches, are then evaluated . Finally, the advantages and disadvantages of each technique, potential research directions, and future perspectives are reported. This review provides a theoretical basis to help veterinarians select the most sensitive, specific, and cost-effective approach for detecting bovine mastitis early.

show abstract

Field study on plasma haptoglobin concentrations and total milk somatic cell counts in cows with untreated and treated mastitis

Cited by 2 publications

References 18 publications

Acute Phase Proteins (Haptoglobin and Serum Amyloid A) and Pro-Inflammatory Cytokines (IL-12 and IL-10) in Cows Vaccinated with Prototype Killed S. aureus Mastitis Vaccine and Challenged with S. aureus Mastitis Infection.

Acute Phase Proteins (Haptoglobin and Serum Amyloid A) and Pro-Inflammatory Cytokines (IL-12 and IL-10) in Cows Vaccinated with Prototype Killed S. aureus Mastitis Vaccine and Challenged with S. aureus Mastitis Infection.

Basic concepts, recent advances, and future perspectives in the diagnosis of bovine mastitis

Contact Info

Product

Resources

About