Field synchronized bidirectional current in confined driven colloids

Meng, Fanyu; Ortiz-Ambriz, Antonio; Massana-Cid, Helena; Vilfan, Andrej; Golestanian, Ramin; Tierno, Pietro

doi:10.1103/physrevresearch.2.012025

Cited by 11 publications

(5 citation statements)

References 45 publications

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“…The SEM image in the inset, obtained with GTT, shows how the adsorbed particles are mostly immersed in the aqueous phase, with a small cap peaking above the interface (see ref. [ 27 ] ). b) The described mechanism is also used to transport two small particles (i and ii) or permanent aggregates of small particles (iii) between two nearby big spheres.…”

Section: Resultsmentioning

confidence: 99%

“…The collective behavior of the transported particles under confinement is found to be relevant in a broad range of systems. [8,11,17,22] Confined micro-swarms are found in a broad range of synthetic and biological systems, such as in the cooperative transport of molecular motors, [23] colloidal rollers on liquid/solid interfaces, [24,25] polarizable microparticles enclosed in narrow volumes, [26,27] growing biofilms [28] or motile synthetic designs and microorganisms confined in microfluidic channels, ducts, blood vessels or fluid and solid interfaces. [29][30][31][32][33][34][35] They exhibit different kind of collective behaviors, [36] ranging from alignment, [25] flocking, [12,[36][37][38] glassy transitions, [39] jamming and clogging phenomena, with temporary or permanent arrest and crystallization.…”

Section: Introductionmentioning

confidence: 99%

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Collective Transport of Magnetic Microparticles at a Fluid Interface through Dynamic Self‐Assembled Lattices

Martínez‐Pedrero

Ortega

Rubio

et al. 2020

Adv Funct Materials

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The transport of confined micron-sized particles plays an important role in a range of phenomena in biology, colloidal science, and solid-state physics. Here, an easily implementable strategy that allows for the collective and monitored transport of magnetic colloidal particles along fluid-fluid interfaces is introduced. Adsorbed microparticles are carried on time-dependent magnetic potentials, generated by dynamic self-assembled lattices of different-sized particles confined onto a parallel plane. In such binary system, the synchronized inversion of the precessing applied field allows for the ballistic and directional transport of the motile components along prescribed directions. The transportation mode can be tuned through the stoichiometry or the strength and orientation of the applied field. The described methodology can be used in the capture and manipulation of drugs or pollutants adsorbed on liquid surfaces, the segregation of colloidal mixtures or the assisted mixture of surface active molecules.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Collective Transport of Magnetic Microparticles at a Fluid Interface through Dynamic Self‐Assembled Lattices

Martínez‐Pedrero

Ortega

Rubio

et al. 2020

Adv Funct Materials

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“…Swimming microrobots capable of autonomously propelling, navigating, and performing various complex tasks in body fluids are attracting a lot of attention (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Inspired by motile microorganisms, such as bacteria, various types of swimming microrobots have been demonstrated to perform efficient locomotion in fluids, propelled by local chemical reactions or external physical stimuli, such as light, magnetic field, or acoustic field (11)(12)(13)(14)(15)(16)(17). Among them, magnetically actuated swimming microrobots hold great potential for active target delivery because they can be navigated into hardto-reach tissues (18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Dual-responsive biohybrid neutrobots for active target delivery

et al. 2021

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Swimming biohybrid microsized robots (e.g., bacteria- or sperm-driven microrobots) with self-propelling and navigating capabilities have become an exciting field of research, thanks to their controllable locomotion in hard-to-reach areas of the body for noninvasive drug delivery and treatment. However, current cell-based microrobots are susceptible to immune attack and clearance upon entering the body. Here, we report a neutrophil-based microrobot (“neutrobot”) that can actively deliver cargo to malignant glioma in vivo. The neutrobots are constructed through the phagocytosis of Escherichia coli membrane-enveloped, drug-loaded magnetic nanogels by natural neutrophils, where the E. coli membrane camouflaging enhances the efficiency of phagocytosis and also prevents drug leakage inside the neutrophils. With controllable intravascular movement upon exposure to a rotating magnetic field, the neutrobots could autonomously aggregate in the brain and subsequently cross the blood-brain barrier through the positive chemotactic motion of neutrobots along the gradient of inflammatory factors. The use of such dual-responsive neutrobots for targeted drug delivery substantially inhibits the proliferation of tumor cells compared with traditional drug injection. Inheriting the biological characteristics and functions of natural neutrophils that current artificial microrobots cannot match, the neutrobots developed in this study provide a promising pathway to precision biomedicine in the future.

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“…Although various drugs using oral or intravascular administration are available, they still suffer from clearance and a rapid transit period in the circulation system and various organs, making them both less effective and showing several side effects (8)(9)(10)(11). Learning from natural motile microorganisms, various propulsion strategies for cutting-edge swimming microrobots have been developed for low Reynolds number environments, using magnetic and acoustic actuation to offer better delivery of therapeutic agents to the diseased region (12)(13)(14)(15)(16)(17)(18)(19)(20). Magnetically powered swimming microrobots have, in particular, exhibited efficient and controllable propulsion in various complex biological media such as the gastrointestinal tract, the ocular vitreous medium, and the extracellular matrix (21)(22)(23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Bioinspired claw-engaged and biolubricated swimming microrobots creating active retention in blood vessels

Sun

et al. 2023

Sci. Adv.

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Swimming microrobots guided in the circulation system offer considerable promise in precision medicine but currently suffer from problems such as limited adhesion to blood vessels, intensive blood flow, and immune system clearance—all reducing the targeted interaction. A swimming microrobot design with clawed geometry, a red blood cell (RBC) membrane–camouflaged surface, and magnetically actuated retention is discussed, allowing better navigation and inspired by the tardigrade’s mechanical claw engagement, coupled to an RBC membrane coating, to minimize blood flow impact. Using clinical intravascular optical coherence tomography in vivo, the microrobots’ activity and dynamics in a rabbit jugular vein was monitored, illustrating very effective magnetic propulsion, even against a flow of ~2.1 cm/s, comparable with rabbit blood flow characteristics. The equivalent friction coefficient with magnetically actuated retention is elevated ~24-fold, compared to magnetic microspheres, achieving active retention at 3.2 cm/s, for >36 hours, showing considerable promise across biomedical applications.

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Field synchronized bidirectional current in confined driven colloids

Cited by 11 publications

References 45 publications

Collective Transport of Magnetic Microparticles at a Fluid Interface through Dynamic Self‐Assembled Lattices

Collective Transport of Magnetic Microparticles at a Fluid Interface through Dynamic Self‐Assembled Lattices

Dual-responsive biohybrid neutrobots for active target delivery

Bioinspired claw-engaged and biolubricated swimming microrobots creating active retention in blood vessels

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