This study presents deterioration in groundwater quality of highly populated region of Punjab Province, Pakistan, by linking chemical data with rain, river recharge, and socioeconomic factors. Various chemical parameters like total dissolved solid (TDS), arsenic (As), fluoride (F − ), Iron (Fe), nitrate (NO 3 − ), nitrite (NO 2 − ), and pH were determined for 46,457 samples collected from 205,344 km 2 area of the Punjab. The samples were collected, stored, and analyzed as per the Environment Protection Agency (EPA) methods at laboratory. Commercial kits were used for analysis of Fe, As, NO 2 − , NO 3 − and F − , while TDS and pH were measured by respective meters. Chemical parameters were correlated with human and animal population, fertilizers consumption, tube wells, industrial density, rain occurrence, and river recharge rate. Data were analyzed using XLSTAT, and GIS 10.3 was used to draw the maps. Spatial classification of the districts was performed by principal component analysis and hierarchal cluster analysis.