Field trial of the efficacy of a combination of ivermectin and praziquantel in horses infected with roundworms and tapeworms

Barrett, Eugene J.; Farlam, J.; Proudman, C. J.

doi:10.1136/vr.154.11.323

Cited by 18 publications

(12 citation statements)

References 16 publications

(16 reference statements)

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“…In Brazil, horses are being used for restoration of public order, military ceremonials, and equestrian sports, such as jumping competitions and riding competitions (Campos, 2017). In equine breeding, parasitic infections represent significant economic losses that affect animal health by causing diseases such as diarrhea and colic and also lead to weak physical conditions and performance (Barrett et al, 2004). The breeding systems of these animals are intensive, extensive, or semi-intensive, and can cause parasitic infections, especially in the first few weeks of life (Molento, 2005).…”

Section: Introductionmentioning

confidence: 99%

Multiple resistance in equine cyathostomins: a case study from military establishments in Rio Grande do Sul, Brazil

Flores

Osmari

Ramos

et al. 2020

Rev. Bras. Parasitol. Vet.

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Semi-intensive equine breeding system favors gastrointestinal nematode infections. The treatment of these infections is based on the use of anthelmintics. However, the inappropriate use of these drugs has led to parasitic resistance to the available active principles. The objective of this study was to evaluate the efficacy of the main classes of antiparasitic (ATP) used in control in adult and young animals, including: benzimidazoles (fenbendazole), pyrimidines (pyrantel pamoate), macrocyclic lactones (ivermectin and moxidectin), as well as the combination of active ingredients (ivermectin + pyrantel pamoate). The study was carried out in two military establishments, located in Rio Grande do Sul (RS), from January to December, 2018. The intervals between the treatments of the animals were performed from 30 to 90 days. Coproparasitological evaluations were determined by the egg count reduction in the faeces. Cyatostomine larvae were identified in pre and post-treatment cultures. The results demonstrated the multiple parasitic resistance of cyathostomins to fenbendazole, moxidectin in young animals, and to fenbendazole, pyrantel pamoate in adult animals. Thus, it is necessary to define or diagnose parasitic resistance to assist in the creation of prophylactic parasitic control, using suppressive treatment with ATP associated with integrated alternatives. The progress of parasitic resistance can be slowed.

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Section: Introductionmentioning

confidence: 99%

Multiple resistance in equine cyathostomins: a case study from military establishments in Rio Grande do Sul, Brazil

Flores

Osmari

Ramos

et al. 2020

Rev. Bras. Parasitol. Vet.

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“…Ivermectin given to horses orally, as a paste or liquid at 0.2 mg/kg bwt, is highly effective (95-100%) against adult and most fourth-stage larvae of cyathostomes, large strongyles, ascarids, pinworms, stomach worms, threadworms and lungworm (Barrett et al 2004). Although an i.m.…”

Section: Introductionmentioning

confidence: 99%

Clinical trial of efficacy of ivermectin pour‐on against gastrointestinal parasitic nematodes in silvopasturing horses

Francisco¹,

Sánchez²,

Cortiñas³

et al. 2009

Equine Veterinary Journal

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The aim of this study was to assess, by a clinical trial, the efficacy of an ivermectin-based pour-on treatment against gastrointestinal parasitic nematodes in naturally infected horses using 2 groups of mature indigenous Pura Raza Galega grazing mares. Faecal and blood samples were collected individually over a 21 week period. Faeces were analysed by the coprological flotation, sedimentation and migration techniques. Changes in circulating blood cells were monitored over the study period. The administration of the ivermectin suppressed the egg-elimination of ascarids and pinworms throughout the study and no strongyle-eggs were observed in the treatment group between the 3rd and 10th weeks. The numbers of red cells increased significantly after the anthelmintic therapy, and a statistical reduction in circulating leucocytes was recorded. No side effects were observed. The pour-on ivermectin formulation was highly successful against gastrointestinal nematodes and appears to be a useful therapeutic routine for large groups of horses.

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“…This is longer than suggested by previous uncontrolled studies (Proudman and Trees 1996, Proudman and Holdstock 2000, Barrett and others 2004) and may be due to differences in the reinfection pressure after their treatment; all the horses in this study shared their original grazing.…”

Section: Discussionmentioning

confidence: 60%

Serological changes observed in horses infected with Anoplocephala perfoliata after treatment with praziquantel and natural reinfection

et al. 2008

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The serological changes in two groups of horses known to be harbouring Anoplocephala perfoliata were studied; 12 were treated with 1.5 mg/kg praziquantel and 200 microg/kg ivermectin, and 14 were treated with 200 microg/kg ivermectin. Serological and faecal analyses were carried out on each animal at intervals for 758 days. The titres of antibodies specific for A perfoliata decreased from the day of treatment to day 28 in both groups, and continued to decrease in the group treated with praziquantel and ivermectin, with the first significant decrease from the other group at day 121. From day 151 to day 295 the first significant increase in antibody levels in the group treated with both drugs was observed; no A perfoliata eggs were detected in the faeces of these animals until day 295 when five of the 10 were positive.

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Field trial of the efficacy of a combination of ivermectin and praziquantel in horses infected with roundworms and tapeworms

Cited by 18 publications

References 16 publications

Multiple resistance in equine cyathostomins: a case study from military establishments in Rio Grande do Sul, Brazil

Multiple resistance in equine cyathostomins: a case study from military establishments in Rio Grande do Sul, Brazil

Clinical trial of efficacy of ivermectin pour‐on against gastrointestinal parasitic nematodes in silvopasturing horses

Serological changes observed in horses infected with Anoplocephala perfoliata after treatment with praziquantel and natural reinfection

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