Field trials of a method of induction of autoimmune gonad rejection in Atlantic salmon (Salmon salar L.)

Laird, Lindsay M.; Wilson, A. R.; Holliday, F. G. T.

doi:10.1051/rnd:19801004

Cited by 20 publications

(5 citation statements)

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“…Immunization of fish at maturity to prevent further maturations cannot be considered a practically useful technique but has the advantage for these experiments that the immune system is fully developed and the gonad possesses all potential auto-antigens. There are a number of different objectives in control of sexual maturation in aquaculture and fisheries management (Laird et al, 1980;Refstie, 1982). In aquaculture there is a need to eliminate secondary sexual characteristics and diversion of somatic growth into gonad development.…”

Section: Discussionmentioning

confidence: 99%

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The long‐term effects of auto‐immunologically induced granulomas on the testes of rainbowtrout, Salmo gairdneri Richardson

Secombes

Needham

Laird

et al. 1985

Journal of Fish Biology

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Complex giant cell granulomas were induced within the testis of mature rainbow trout following immunization with testis in Freund's complete adjuvant. Although such granulomas could completely fill the seminiferous tubules and sperm duct, they had no inhibitory effect on spermatogenesis during a subsequent maturation. Germ cells developed normally around the periphery of the granulomas. The spermatozoa produced, however, were often prevented from being released by the presence of these long-term granulomas within the sperm duct.

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Section: Discussionmentioning

confidence: 99%

“…The purpose of these experiments is to develop an immunological means to control sexual maturation in fish (Laird et al, 1978(Laird et al, , 1980. This paper examines whether the mature fish in which an auto-immune reaction to gonad tissue has been confirmed can show normal maturation in a subsequent breeding season.…”

Section: Introductionmentioning

confidence: 99%

The long‐term effects of auto‐immunologically induced granulomas on the testes of rainbowtrout, Salmo gairdneri Richardson

Secombes

Needham

Laird

et al. 1985

Journal of Fish Biology

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“…While immunocontraception serves the purpose of preventing outbreak of mammalian pest populations, it is not suitable for aquaculture as it does not affect gonadal development and the associated deteriorated growth and flesh quality. A study on rainbow trout ( Oncorhynchus mykiss ) demonstrated that injection of a gonadal extract resulted in a limited autoimmune response in gonads [16] . However, that study was performed on few individuals only and no recent published studies have explored this concept further.…”

Section: Introductionmentioning

confidence: 99%

Induced Autoimmunity against Gonadal Proteins Affects Gonadal Development in Juvenile Zebrafish

et al. 2014

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A method to mitigate or possibly eliminate reproduction in farmed fish is highly demanded. The existing approaches have certain applicative limitations. So far, no immunization strategies affecting gonadal development in juvenile animals have been developed. We hypothesized that autoimmune mechanisms, occurring spontaneously in a number of diseases, could be induced by targeted immunization. We have asked whether the immunization against specific targets in a juvenile zebrafish gonad will produce an autoimmune response, and, consequently, disturbance in gonadal development. Gonadal soma-derived factor (Gsdf), growth differentiation factor (Gdf9), and lymphocyte antigen 75 (Cd205/Ly75), all essential for early gonad development, were targeted with 5 immunization tests. Zebrafish (n = 329) were injected at 6 weeks post fertilization, a booster injection was applied 15 days later, and fish were sampled at 30 days. We localized transcripts encoding targeted proteins by in situ hybridization, quantified expression of immune-, apoptosis-, and gonad-related genes with quantitative real-time PCR, and performed gonadal histology and whole-mount immunohistochemistry for Bcl2-interacting-killer (Bik) pro-apoptotic protein. The treatments resulted in an autoimmune reaction, gonad developmental retardation, intensive apoptosis, cell atresia, and disturbed transcript production. Testes were remarkably underdeveloped after anti-Gsdf treatments. Anti-Gdf9 treatments promoted apoptosis in testes and abnormal development of ovaries. Anti-Cd205 treatment stimulated a strong immune response in both sexes, resulting in oocyte atresia and strong apoptosis in supporting somatic cells. The effect of immunization was FSH-independent. Furthermore, immunization against germ cell proteins disturbed somatic supporting cell development. This is the first report to demonstrate that targeted autoimmunity can disturb gonadal development in a juvenile fish. It shows a straightforward potential to develop auto-immunization-based technologies to mitigate fish reproduction before they reach maturation. However, the highly variable results between treatments and individuals suggest significant optimization should be performed to achieve the full potential of this technology.

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“…L7rradiation précoce des gonades provoque la destruction des cellules sexuelles (Purdom et Woodhead, 1973 Donaldson, 1972 ;Laird et al, 1981). …”

unclassified

La gonadogenèse des Poissons

Brusle¹,

Bruslé²

1983

Reprod. Nutr. Dévelop.

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Field trials of a method of induction of autoimmune gonad rejection in Atlantic salmon (Salmon salar L.)

Abstract: Summary. Autoimmune Introduction.

Cited by 20 publications

References 11 publications

The long‐term effects of auto‐immunologically induced granulomas on the testes of rainbowtrout, Salmo gairdneri Richardson

The long‐term effects of auto‐immunologically induced granulomas on the testes of rainbowtrout, Salmo gairdneri Richardson

Induced Autoimmunity against Gonadal Proteins Affects Gonadal Development in Juvenile Zebrafish

La gonadogenèse des Poissons

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