Field trials with Vedaprofen, a new non‐steroidal anti‐inflammatory drug

A comparison of pre and post-operative vedaprofen with ketoprofen for pain control in dogs

“…It is available as a palatable gel formulation, which has a rapid and almost complete absorption after oral administration in dogs. The oral route has a terminal half-live of the same order of magnitude of the intravenous administration [ 16 ], but with the advantage that the oral route is less stressful to the animal and can be easily administered by the owner during postoperative home care [ 17 ]. Vedaprofen is known to preferentially inhibit the cyclo-oxygenase-2 in dogs [ 18 ], and it is apparently safe in this species, as there was a low incidence of gastrointestinal changes, like vomiting and diarrhea after a long-term treatment for 30–56 days [ 13 , 14 ].…”

A comparison of the analgesic efficacy of vedaprofeno, carprofen or ketofen after ovariohysterectomy in bitches

“…Studies investigating vedaprofen in dogs and horses found that it is a safe and satisfactory NSAID to prevent the acute release of inflammatory mediators, while providing excellent gastrointestinal and renal tolerance in these especies (BERGMAN et al, 1996;LEES et al, 1998). Although the pharmacokinetics of vedaprofen has been studied in dogs (HOEIJMAKERS et al, 1994), little information is available on its postoperative analgesic effects.…”