Fifteen years of bone tumor cryosurgery: A single-center experience of 440 procedures and long-term follow-up

No Recurrences in Selected Patients after Curettage with Cryotherapy for Grade I Chondrosarcomas

“…Although we have no data, we believe the sheets helped protect the incised skin and muscle and we replaced the sheets after each of the three instillations of liquid nitrogen into the tumor cavity. The risk of fracture was reported from 1% (four of 440) by Meller et al [19] to 20% by Marco et al [17]. Van der Geest et al reported a rate of 14% in a series of 130 enchondromas and Grade I chondrosarcomas, six fractures in the proximal humerus and 12 in the distal femur [30].…”

“…Each author certifies that his or her institution has approved the reporting of these cases, that all investigations were conducted in conformity with ethical principles of research, and that informed consent was obtained. intralesional treatment of these low-grade chondrosarcomas combining tumor excision with skeletal conservation [1,14,18,19,24,28]. After curettage alone, Bauer et al noted two cases of recurrence among 23 patients with chondrosarcomas [2].…”

What are the Oncologic and Functional Outcomes After Joint Salvage Resections for Juxtaarticular Osteosarcoma About the Knee?

“…When the tumor transgresses the physes with no hope of growth-plate preservation, the surgical goal should be retaining as much epiphysis as possible. Microwave and argon-based ablations are tools that have been widely used for primary and metastatic malignancy [11,31,43]. Both methods could devitalize a tumor in situ through an antenna.…”

Anatomical model-based finite element analysis of the combined cryosurgical and hyperthermic ablation for knee bone tumor

“…Clinical practice for cryosurgery suggested that maximum cryoinjury is achieved when the target tissue undergo below so-called lethal temperature −40 • C [31][32][33]. In addition, another two key temperature −20 • C and −10 • C are tracked for bone [4,23]. The Arrhenius damage model is often used to determine the boundaries of hyperthermic ablation zone, where two parameters should be given from experimental measurements.…”

“…The bone tumors often occur at the distal femur. Meller [4] has reported 440 cryosurgical treatments for bone tumor, where about 87 cases were located at the distal femur. In current work, we thus predefine a large ellipsoidal bone tumor at the left distal femur (shown in Fig.…”