Fifteen years of imposex and tributyltin pollution monitoring along the Portuguese coast

Laranjeiro, Filipe; Sánchez-Marín, Paula; Oliveira, Isabel; Galante-Oliveira, Susana; Barroso, Carlos M.

doi:10.1016/j.envpol.2017.09.056

Cited by 67 publications

(34 citation statements)

References 53 publications

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“…Imposex is when female sea snails develop male sex organs, such as a penis and a vas deferens. This phenomenon was first reported in the 70's (Smith, ) and proposed as an indicator of TBT presence in several studies on molluscs (Laranjeiro, Sánchez‐Marín, Oliveira, Galante‐Oliveira, & Barroso, ). However, no OECD test guideline has been defined, because the mode‐of‐action of TBT underpinning imposex is still not clear, although some clues point out to retinoid X receptor (RXR) and PPAR (Lagadic et al, ; Pascoal et al, ).…”

Section: Introductionmentioning

confidence: 71%

Potential roles of nuclear receptors in mediating neurodevelopmental toxicity of known endocrine‐disrupting chemicals in ascidian embryos

Gomes

Gazo

Besnardeau

et al. 2019

Molecular Reproduction Devel

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Endocrine Disrupting Chemicals (EDCs) are molecules able to interfere with the vertebrate hormonal system in different ways, a major one being the modification of the activity of nuclear receptors (NRs). Several NRs are expressed in the vertebrate brain during embryonic development and these NRs are suspected to be responsible for the neurodevelopmental defects induced by exposure to EDCs in fishes or amphibians and to participate in several neurodevelopmental disorders observed in humans. Known EDCs exert toxicity not only on vertebrate forms of marine life but also on marine invertebrates. However, because hormonal systems of invertebrates are poorly understood, it is not clear whether the teratogenic effects of known EDCs are because of endocrine disruption. The most conserved actors of endocrine systems are the NRs which are present in all metazoan genomes but their functions in invertebrate organisms are still insufficiently characterized. EDCs like bisphenol A have recently been shown to affect neurodevelopment in marine invertebrate chordates called ascidians. Because such phenotypes can be mediated by NRs expressed in the ascidian embryo, we review all the information available about NRs expression during ascidian embryogenesis and discuss their possible involvement in the neurodevelopmental phenotypes induced by EDCs. K E Y W O R D S endocrine-disrupting chemicals, marine invertebrate, mode-of-action, neurodevelopment, nuclear receptors

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Section: Introductionmentioning

confidence: 71%

Potential roles of nuclear receptors in mediating neurodevelopmental toxicity of known endocrine‐disrupting chemicals in ascidian embryos

Gomes

Gazo

Besnardeau

et al. 2019

Molecular Reproduction Devel

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“…Persistence of organotin pollution in conditions such as fine-grained, organic-rich, mostly anoxic coastal sediments (48, 49) has made TBT and other organotins legacy pollutants, being considered as POPs by WHO-UNEP (1). As a matter of fact, this is probably the most important reason that would explain why imposex is still being reported in European waters (50–53), even when clear instances of improvement are being reported (54). The same occurs in other areas were organotins uses were banned, such as Korea, for instance (55, 56).…”

Section: Endocrine Disruption: Detection and Evaluation Of Effects Inmentioning

confidence: 99%

“…The widespread occurrence of imposex female aphally renders penis lengths indexes meaningless (for instance, total female aphally was recorded for 9 out of 19 stations for imposex monitoring in Nucella lapillus in 2014, causing values for RPLI in this species along the Portuguese coast to drop to almost zero, thus rendering its application unable to further indicate decreasing tendencies afterward but for one sampling station along the Portuguese coast [(53), Table 1]. The same observation was reported in Hexaplex trunculus , showing a temporal reduction pattern of phallic imposex development as observed in Stramonita brasiliensis in Brazil, by Lahbib et al (78) in Tunisia.…”

Section: Endocrine Disruption: Detection and Evaluation Of Effects Inmentioning

confidence: 99%

Populations Collapses in Marine Invertebrates Due to Endocrine Disruption: A Cause for Concern?

Fernandez

2019

Front. Endocrinol.

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In the beginning of the twenty first century, the International Program on Chemical Safety published a document entitled Global Assessment of the State-Of-The-Science of Endocrine Disruptors. The work indicated only weak evidence of endocrine-related effects in human populations, and in wild animal populations. This document was revised in 2012 (State of the Science of Endocrine Disrupting Chemicals−2012) (1). The new document and the extensive scientific evidence it provided showed clearly that ED effects could be a risk to human and wildlife health. These works, however, were focused in human health and related animal models, mainly vertebrates and particularly mammals. It can be argued that invertebrates and many other taxa are important parts of all ecosystems, and, in many instances, have been shown to be also vulnerable to endocrine disruption. Thus, this work is aimed to show some observations on important marine invertebrate taxa, from an ecological point of view. The most important example of endocrine disruption in marine wild populations is the imposex response of marine gastropods, known for more than 40 years, and worldwide used to evaluate marine antifouling pollution. Among the mollusks, other important natural resources are bivalve species, used as human food sources and cephalopods, free-living, highly specialized mollusks, and also human food sources. Effects derived from endocrine disruptors in these species indicate that consumption could bring these compounds to human populations in an almost direct way, sometimes without any form of cooking or preparation. While discussing these questions, this work is also aimed to stimulate research on endocrine disruption among the invertebrate taxa that inhabited our oceans, and on which these effects are poorly known today.

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“…In 2008, The International Convention on the Control of Harmful Anti‐fouling Systems on Ships, implemented by the International Maritime Organization, established a global ban on the use of organotin compounds as biocides in antifouling systems on ships. Recent estimates indicate declining organotin concentrations and amelioration of imposex endpoints in Europe (Cacciatore et al 2018; Laranjeiro et al 2018). Seawater concentrations of tributyltin decreased more than 50‐fold from 11.3 ng Sn L –1 in 1997 to 0.2 ng Sn L –1 in the semiclosed Jinhae Bay in South Korea (Kim et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Histological and Behavioral Toxicity of Tributyltin in the Tropical Guppy Poecilia vivipara

Paulo

Mariz

Alves

et al. 2020

Enviro Toxic and Chemistry

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The tropical estuarine guppy Poecilia vivipara was used to address fish early life stage toxicity caused by the antifouling contaminant tributyltin. Six-day-old P. vivipara were exposed for 7 d to control water and waterborne tributyltin at 15.8, 83.8, 716, and 818 ng tin (Sn) L-1. After exposure, swimming, feeding, growth, and eye histological endpoints were evaluated. Histopathological analysis of the retinal pigment epithelium (RPE) indicated alterations in pigment positioning at all tributyltin concentrations. A dose-dependent increase in photoreceptor layer disorganization and iris melanin hyperpigmentation was verified, and high frequencies of RPE invaginations and iris epithelial cell atrophy were observed even at the lowest exposure concentration of 15.8 ng Sn L-1. At the highest exposure level (818 ng Sn L-1) fish also presented reductions in swimming speed, swimming resistance, daily capture of Artemia nauplii, and growth in weight of 85, 60, 33, and 56% relative to controls, respectively. This association between retinal histopathology and reduced swimming and foraging behavior can reduce recruitment to the adult population.

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Fifteen years of imposex and tributyltin pollution monitoring along the Portuguese coast

Cited by 67 publications

References 53 publications

Potential roles of nuclear receptors in mediating neurodevelopmental toxicity of known endocrine‐disrupting chemicals in ascidian embryos

Potential roles of nuclear receptors in mediating neurodevelopmental toxicity of known endocrine‐disrupting chemicals in ascidian embryos

Populations Collapses in Marine Invertebrates Due to Endocrine Disruption: A Cause for Concern?

Histological and Behavioral Toxicity of Tributyltin in the Tropical Guppy Poecilia vivipara

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