Fifth day fits: a syndrome of neonatal convulsions.

Pryor, D S; Don, N.; Macourt, David C.

doi:10.1136/adc.56.10.753

Cited by 47 publications

(18 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in Goldberg's series there was no definite cause for 55 per cent (Goldberg 1983). This cryptogenic group is heterogenous; about half have familial benign neonatal seizures or 'fifth day' fits (Pryor et al 1981) and have a good prognosis. However, some are apparently normal term infants with multiple, prolonged seizures of unknown cause and a poor prognosis (Harris andTizard 1960, Eriksson andZetterstrom 1979).…”

Section: Discussionmentioning

confidence: 96%

Early Infantile Epileptic Encephalopathy With Suppression Burst: Ohtahara Syndrome

Clarke¹,

Gill

Noronha

et al. 1987

Develop Med Child Neuro

View full text Add to dashboard Cite

SUMMARY Eleven infants with neonatal onset of intractable epilepsy are described, who showed the clinical and electroencepahlographic features of Ohtahara syndrome. With time, transition to West and Lennox‐Gastaut syndromes occurred. No cause could be found in eight cases. All nine survivors are severely mentally and physically handicapped and continue to have seizures. Early infantile epileptic encephalopathy represents the earliest of the age‐dependent epileptic encephalopathies. RÉSUMÉ Encéphalopathie épileptogène infantile précoce avec bouffée suppressive (syndrome d'Ohtahara) L'article décrit 11 nourrissons avec un début néonatal d'épilepsie incurable présentant les caractéristiques cliniques et électroencéphalographiques du syndrome d'Ohtahara. Avec le temps, une transition survint vers les syndromes de West et de Lennox‐Gastaut. Aucune cause ne fut retrouvée dans huit cas. Les neuf survivants sont tous gravement handicapés sur les plans mental et physique et continuent à avoir des crises. L'encéphalopathie épileptogene infantile précoce représente la plus précoce des encéphalopathies épileptogènes reliées a l'âge. ZUSAMMENFASSUNG Infantile epileptische Encephalopathie mit burst suppression Muster (Ohtahara Syndrom) Es werden 11 Kinder mit einer im Neugeborenenalter beginnenden, unbeeinflußbaren Epilepsie beschrieben, die klinische und elektroencephalographische Merkmale des Ohtahara Syndroms aufwiesen. Im Verlauf traten Übergänge zu den West‐ und Lennox‐Gastaut Syndromen auf. In acht Fällen konnte keine Ürsache gefunden werden. Alle neun Überlebenden sind geistig und körperlich schwer behindert und haben weiterhin Anfälle. Die frühinfantile epileptische Encephalopathie ist die am frühsten auftretende altersabhängige epileptische Encephalopathie. RESUMEN Encefalopatia epileptica infantile precoz con accesos de supresión (sindrome de Ohtahara) Se describen once lactantes con epilepsia intratable de inicio neonatal, que mostraron las carasteristicas clinicas y EEG del sindrome de Ohtahara. Con el tiempo tuvo lugar su paso al sindrome de West y de Lennox‐Gastaut. No se halló ninguna etiologia en ocho casos. Todos los neuve supervivientes eran gravemente minusválidos, tanto mental como fisicamente y continuaron teniendo ataques. La encefalopatia epiléptica infantil precoz representa la más temprana de las encefalopatias epilépticas dependientes de la edad.

show abstract

Section: Discussionmentioning

confidence: 96%

Early Infantile Epileptic Encephalopathy With Suppression Burst: Ohtahara Syndrome

Clarke¹,

Gill

Noronha

et al. 1987

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

“…BFNC should be distinguished from a sporadic, nongenetic form of neonatal convulsions termed "fifth-day fits" (67,68), in which seizures occur in healthy term infants, often on the fourth or fifth days of life. The seizures last for -24 h, are refractory to drug therapy, and have no established etiology.…”

Section: Benign Familial Neonatal Convulsionsmentioning

confidence: 99%

Recent Advances in the Genetics of Epilepsy: Insights from Human and Animal Studies

Prasad

Stafstrom

1999

Epilepsia

View full text Add to dashboard Cite

Summary: Progress in understanding the genetics of epilepsy is proceeding at a dizzying pace. Due in large part to rapid progress in molecular genetics, gene defects underlying many of the inherited epilepsies have been mapped, and several more are likely to be added each year. In this review, we summarize the available information on the genetic basis of human epilepsies and epilepsy syndromes, and correlate these advances with rapidly expanding information about the mechanisms of epilepsy gained from both spontaneous and transgenic animal models. We also provide practical suggestions for clinicians confronted with families in which multiple members are afflicted with epilepsy. Key Words: Epilepsy-GeneticsHuman-Pathophysiology-Animal models.Over the past few years, there has been an explosion of information about the genetic basis of epilepsy and epilepsy syndromes. Some of these advances have been documented in recent reviews (1-6). In parallei with advances in understanding the genetics of human epilepsies, several spontaneous and transgenic animal models of inherited epilepsy have been produced. These approaches will expand our ability to dissect cellular mechanisms of seizure generation and propagation and help us to move from serendipity to rationality in designing targeted therapies for seizure disorders (7,8). In this review we summarize the recent progress in mapping genes for human epilepsy, describe some relevant animal models of genetic epilepsy, and examine the relation between gene defects and the cellular mechanisms of epilepsy. Finally, we provide practical suggestions for clinicians caring for patients and families with inherited epilepsies. Clinical details of the various epilepsy syndromes, available elsewhere, are largely omitted here.Epilepsy, characterized by recurrent seizures, results from excessive synchronous firing of neurons in cortical networks. A number of intricately linked mechanisms at the network, cellular, subcellular, and molecular levels

show abstract

“…Despite an overall poor prognosis for both survival and future impairments (largely cognitive and motor), separating the syndromes into those with a comparatively good outcome and those with a poor outcome is useful. Those with a good outcome include benign familial neonatal seizures, fifth day seizures,4 and seizures secondary to hypocalcaemia and subarachnoid haemorrhage. Those with a poor outcome include seizures secondary to hypoxic ischaemic encephalopathy and developmental brain defects.…”

Section: Neonatal Seizuresmentioning

confidence: 99%

Fortnightly review: Epilepsy in childhood

Neville

1997

BMJ

View full text Add to dashboard Cite

Fifth day fits: a syndrome of neonatal convulsions.

Cited by 47 publications

References 6 publications

Early Infantile Epileptic Encephalopathy With Suppression Burst: Ohtahara Syndrome

Early Infantile Epileptic Encephalopathy With Suppression Burst: Ohtahara Syndrome

Recent Advances in the Genetics of Epilepsy: Insights from Human and Animal Studies

Fortnightly review: Epilepsy in childhood

Contact Info

Product

Resources

About