Fifty years of bone tumors

Bartelstein, Meredith K.; Boland, Patrick J.

doi:10.1002/jso.27027

Cited by 6 publications

(5 citation statements)

References 73 publications

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“…За последние десятилетия были достигнуты существенные улучшения в диагностике и лечении опухолей костей. Благодаря применению химиотерапии органосохраняющие операции заменили ампутацию, однако увеличение показателей выживаемости и уменьшение количества рецидивов затормозилось [2,3,[9][10][11][12]. Несмотря на это в мире изучаются новые направления в лечении опухолей костей: различные виды ТА, иммунная, таргетная терапия [2, 3, 11-13, 17, 18].…”

Section: заключениеunclassified

“…Частота их встречаемости не превышает 1 % всех злокачественных новообразований человека [1]. Несмотря на достижения современной медицины, смертность от данной патологии может достигать 50 % [2]. Главными задачами ее лечения являются уничтожение всех возможных опухолевых клеток и восстановление больших или функционально значимых костных дефектов [3].…”

Section: Introductionunclassified

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Radical intraoperative thermal ablation of osteogenic sarcoma: clinical observation

Anisenya,

Sitnikov,

Pakhmurin

et al. 2023

jour

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Introduction. Difficult diagnosis, aggressive progression, and absence of an increase in treatment effectiveness (especially in patients with osteosarcoma and Ewing sarcoma) make malignant tumors of the bones a significant medical problem. Use of traditional therapy methods is often associated with development of drug resistance and frequent recurrences. Therefore, there is a need for new treatment strategies and overcoming of the limitations of traditional methods through their improvement, combination or substitution to achieve higher survival, lower recurrence rate, and wider availability for patients with bone tumors.Aim. To present a clinical observation of the use of a new method of radical intraoperative thermal ablation for bone tumors, assess exposure tolerance, long-term oncological and functional results.Clinical observation. This article presents a clinical case of the use of a new radical treatment method for a patient with tibial osteosarcoma who underwent intraoperative thermal ablation using a new domestic complex of local hyperthermia “Phoenix-2”.Results. A session of intraoperative thermal ablation was performed in the operating room under anesthesia directly in the wound for 48 minutes. Access to the tumor-affected bone was performed with the standard oncological approach (en-block), the bone was not transected or removed. A constant heating mode of 90 °С was used, assuming a gradual increase in temperature. Thus, 60 °С reached 20 minutes, and the temperature at the end of high-temperature exposure was 78 °С (inside the medullary canal). The operation time was 2 hours 30 minutes. The postoperative period proceeded without complications. After 38 months of follow-up, examinations did not reveal any recurrence or progression in the patient.Conclusion. The technique of radical intraoperative thermal ablation using a local hyperthermia complex Phoenix-2 is effective and allows to widen the toolkit of treatment methods for patients with bone tumors. It can serve as an alternative or addition to organ-preserving surgical treatment without costly reconstruction stages.

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Section: заключениеunclassified

Section: Introductionunclassified

Radical intraoperative thermal ablation of osteogenic sarcoma: clinical observation

Anisenya,

Sitnikov,

Pakhmurin

et al. 2023

jour

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“…Although recovery after arthroplasties is facilitated by the application of protocols such as Enhanced Recovery After Surgery for primary hip and knee arthroplasty [ 15 , 16 , 17 ], as well as the provision of basic elements in improvement pathways [ 18 ], there is an increase in the incidence of the total hip and knee revision procedures [ 19 ]. At the same time, the number of operated fractures [ 20 , 21 ] and bone tumors [ 22 , 23 ] are also increasing. All this will lead to an increase in healthcare expenses in the future [ 24 , 25 ], even during periods of economic recession [ 10 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Research on the Prevalence and Evolution Trend of Orthopedic Surgeries in Romania

Moldovan

Bățagă

2023

Healthcare

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Accurate knowledge of the prevalence and trends of orthopedic surgeries can facilitate the design of medical plans for effective treatments. The National Endoprosthetic Registry (NER) in Romania provides statistics on endoprosthetic activity (hip, knee), cases of fractures and bone tumors as a result of the legal obligations to report interventions performed by all orthopedic traumatology hospitals/wards in the country. The aim of this study is to describe the annual volumes of orthopedic surgeries between 2001 and 2022 in Romania and analyze the current and future evolution trends of the studied surgeries, gender differences and regional differences based on a complete survey carried out at a national level. For the period 2001–2022, we extracted from the NER the annual volumes of orthopedic interventions performed. With these data, we studied the prevalence and estimated, with the support of an original calculation methodology, the variation trends of orthopedic surgeries in two situations: over the entire 21-year period, respectively, and over the period 2001–2020, which does not include the pandemic period. For hip replacement surgery and knee replacement surgery, we showed the prevalence by subcategory of interventions, gender distribution, regional prevalence and regional density calculated by the annual averages of the total number of cases reported per 100,000 people in the 40 counties of the country and the capital, Bucharest. We also determined the variations in hip and knee arthroplasty revision burdens, calculated as a percentage between the number of revisions and the number of primary interventions in the same period. We determined the regional densities of revision burdens. The total number of orthopedic surgeries in the period 2001–2022 was 1,557,247, of which 189,881 were hip replacement surgeries; 51,035 were knee replacement surgeries; 11,085 were revision hip arthroplasty; 1497 were revision knee arthroplasty; 541,440 were operated fractures; and 16,418 were operated bone tumors. The growth rates of surgical interventions are hip replacement surgery, +8.19%; knee replacement surgery, +19.55%; revision hip arthroplasty, +9.43%; and revision knee arthroplasty, +28.57%. With these data, we have estimated a doubling of the volume of primary and revision interventions of the hip until 2034 and the knee until 2027, respectively. Operated bone tumors register an annual decrease of −4.52% thanks to modern treatments. There are clear gender differences; for primary hip interventions, the proportion of women is 58.82%, and for knee interventions, the proportion of women is 76.42%. This is the first research that, with the support of exhaustive data from the NER, analyzes for the period 2001–2022 the annual number of orthopedic surgeries in Romania. It allows knowledge of the large, anticipated increases in orthopedic surgery and provides a quantitative basis for future policy decisions related to the need for medical personnel and material resources.

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Orthopaedic oncology has evolved dramatically as a discipline over the past 50 years. [1][2][3][4] With the advent of subspecialty fellowship training and transdisciplinary collaboration, our field has pushed the intellectual boundaries on several academic fronts, some of which we will highlight in this special edition of JSO. Broadly, we have chosen to focus on (1) outcomes, disparities and quality of life; (2) surgical management and technological developments; and (3) nonsurgical advancements.

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confidence: 99%

“…Orthopaedic oncology has evolved dramatically as a discipline over the past 50 years 1–4 . With the advent of subspecialty fellowship training and transdisciplinary collaboration, our field has pushed the intellectual boundaries on several academic fronts, some of which we will highlight in this special edition of JSO.…”

mentioning

confidence: 99%