Fifty years of carborane chemistry: the history of discovery and the first results

Bregadze, V. I.

doi:10.1007/s11172-014-0543-5

Cited by 17 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carboranes display a rich chemistry, at the level of the C−H groups, but also in some cases at the level of B−H groups. The chemistry of carboranes has been reviewed [ 7 , 8 ], in particular with emphasis on their biological properties [ 9 ]. Indeed, the large number of boron atoms present in these boron clusters made them desirable instruments for cancer treatment using boron neutron capture therapy (BNCT).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Indeed, the large number boron atoms present in these boron clusters made them desirable instruments for canc treatment using boron neutron capture therapy (BNCT). The starting materials for BNC are based on 10 B, which is a nonradioactive constituent of the natural elemental boro Irradiation of 10 B with low energy thermal neutrons yields high linear energy transf (LET) α particles ( 4 He) and recoiling 7 Li nuclei [10] (Scheme 2). Scheme 2.…”

Section: Introductionmentioning

confidence: 99%

“…The starting materials for BNCT are based on 10 B, which is a nonradioactive constituent of the natural elemental boron. Irradiation of 10 B with low energy thermal neutrons yields high linear energy transfer (LET) α particles ( 4 He) and recoiling 7 Li nuclei [10] (Scheme 2). In order to sustain a deadly 10 B(n,α) 7 Li capture reaction, enough thermal neutrons must be captured by 10 B (neutron capture cross-section is 3840 barn) to produce the high LET particles due to their constrained path lengths in tissues (5-9 µm).…”

Section: Introductionmentioning

confidence: 99%

“…Irradiation of 10 B with low energy thermal neutrons yields high linear energy transfer (LET) α particles ( 4 He) and recoiling 7 Li nuclei [10] (Scheme 2). In order to sustain a deadly 10 B(n,α) 7 Li capture reaction, enough thermal neutrons must be captured by 10 B (neutron capture cross-section is 3840 barn) to produce the high LET particles due to their constrained path lengths in tissues (5-9 µm). For this reason, a sufficient amount of 10 B must be delivered to the tumor (≈20 µg/g or ≈10 9 atoms/cell), making boron clusters appealing delivery systems for this purpose.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties

2023

View full text Add to dashboard Cite

The presence of a large number of boron atoms in boron clusters make them attractive tools for the treatment of cancer using boron neutron capture therapy (BNCT). Since the quantity of boron atoms present in the target cell directly affects the effectiveness of BNCT, the idea of gathering a high number of boron atoms in a single entity has emerged many years ago. In this perspective, using hyper-branched macromolecules such as dendrimers appears as an interesting solution. In this review, we will first present the synthesis of diverse dendritic entities (dendrimers, dendrons, and Janus dendrimers) that incorporate boron clusters, in particular carboranes, anywhere in their structure. Four parts of this review present the synthesis of dendrimers having boron clusters on the surface, or inside their structure, of dendrons and of Janus dendrimers, bearing boron clusters. Practically all these boronated dendritic structures were synthesized with the objective to study their biological properties, but in fact only a few of them have been tested against cancerous cells, and even a smaller number was tested in BNCT experiments. The biological experiments are discussed in the fifth part of this review. A good efficiency is generally observed with the boronated dendrimers, even in animal models, with an increase in their mean survival time (MST).

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties

2023

View full text Add to dashboard Cite

show abstract

Substituent Effects on the Fluorescence Properties of ortho‐Carboranes: Unusual Emission Behaviour in C‐(2′‐Pyridyl)‐ortho‐carboranes

et al. 2016

View full text Add to dashboard Cite

Seventeen compounds including the parent ortho-, meta-and para-carboranes and derivatives of ortho-carborane were investigated for luminescence in cyclohexane and dichloromethane solutions. Fifteen of these carboranes revealed very weak emissions in the 285-493 nm range. These carboranes may arguably be viewed as non-emissive in solutions at room temperatures. No emissions could be observed for 1,2-dimethyl-ortho-carborane and 2-methyl-1-phenyl-ortho-carborane. The carboranes with a 2′-pyridyl substituent at the cluster

show abstract

(N,Se) and (Se,N,Se) Ligands Based on Carborane and Pyridine Fragments – Reactivity of 2,6‐[(1′‐Me‐1′,2′‐closo‐C₂B₁₀H₁₀)SeCH₂]₂C₅H₃N towards Copper and Silver

et al. 2017

View full text Add to dashboard Cite

Two new closo-carborane selenolated ligands, 2-[(1′-Me-1′,2′-closo-C 2 B 10 H 10 )SeCH 2 ]C 5 H 4 N (L 1 ) and 2,6-[(1′-Me-1′,2′closo-C 2 B 10 H 10 )SeCH 2 ] 2 C 5 H 3 N (L 2 ), were prepared by the C-H activation of 1-Me-1,2-C 2 B 10 H 11 with nBuLi, followed by the insertion of elemental selenium into the C-Li bond and reaction with 2-(BrCH 2 )C 5 H 4 N or 2,6-(BrCH 2 ) 2 C 5 H 3 N, respectively. The closo species L 1 and L 2 were deboronated with CsF to give the nido-carborane cesium salts Cs[2-{(1′-Me-1′,2′-nido-C 2 B 9 H 9 )SeCH 2 }C 5 H 4 N] (1) and Cs 2 [2,6-{(1′-Me-1′,2′-nido-C 2 B 9 H 9 )- [a]

show abstract

Fifty years of carborane chemistry: the history of discovery and the first results

Cited by 17 publications

References 39 publications

Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties

Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties

Substituent Effects on the Fluorescence Properties of ortho‐Carboranes: Unusual Emission Behaviour in C‐(2′‐Pyridyl)‐ortho‐carboranes

(N,Se) and (Se,N,Se) Ligands Based on Carborane and Pyridine Fragments – Reactivity of 2,6‐[(1′‐Me‐1′,2′‐closo‐C₂B₁₀H₁₀)SeCH₂]₂C₅H₃N towards Copper and Silver

Contact Info

Product

Resources

About

Fifty years of carborane chemistry: the history of discovery and the first results

Cited by 17 publications

References 39 publications

Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties

Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties

Substituent Effects on the Fluorescence Properties of ortho‐Carbor­anes: Unusual Emission Behaviour in C‐(2′‐Pyridyl)‐ortho‐carboranes

(N,Se) and (Se,N,Se) Ligands Based on Carborane and Pyridine Fragments – Reactivity of 2,6‐[(1′‐Me‐1′,2′‐closo‐C2B10H10)SeCH2]2C5H3N towards Copper and Silver

Contact Info

Product

Resources

About

Substituent Effects on the Fluorescence Properties of ortho‐Carboranes: Unusual Emission Behaviour in C‐(2′‐Pyridyl)‐ortho‐carboranes

(N,Se) and (Se,N,Se) Ligands Based on Carborane and Pyridine Fragments – Reactivity of 2,6‐[(1′‐Me‐1′,2′‐closo‐C₂B₁₀H₁₀)SeCH₂]₂C₅H₃N towards Copper and Silver