The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has stressed the importance of the use of personal protective of personal protective equipment (PPE). In the present time, face masks, as representative example of PPE, demonstrated useful significant contribution in COVID-19 pandemic management effectively. However, these commonly used face masks are made of materials without inactivation properties against either SARS-CoV-2 or multidrugresistant bacteria. Therefore, symptomatic and asymptomatic individuals can infect other people even if they wear them since some viable microbial loads can escape from the masks. Furthermore, microbial contact transmission can occur by touching the mask, and they are an increasing source of contaminated biological waste. In this regard, during the current pandemic, many researchers have been working on the development of face masks made of advanced materials with intrinsic antimicrobial properties to avoid these problems, and thus provide extra protection against pathogens. In this dazzling race against COVID-19, this review presents the types of commercialized face mask, their main fabrication methods and treatments, and the progress achieved in the development of smart antimicrobial face masks.