Background: The Promoting Action on Research Implementation in Health Services (PARIHS) framework was utilized to design an evidence-based practice, Cocoa360’s COVID Preparedness & Outbreak Prevention Plan (CoCoPOPP), for rural communities in Ghana. Through participatory academic-community team discussion, interactive dissemination, systematic review of evidence about community-based interventions during Ebola, HIV/AIDS, and Influenza outbreaks and effective engagement with local and national stakeholders, CoCoPOPP was developed to be consistent with the PARIHS framework. Methods: Applying the three core elements of the PARIHS framework (evidence, context, and facilitation), the designers developed orientation, logistic needs and planning, and social mobilization. Components of CoCoPOPP also included participant recruitment and training, communication, research, monitoring & evaluation plan, execution, technical assistance, and facilitation. Results: This intervention achieved three (3) main aims: (1) meet a pressing health need during the COVID-19 pandemic in local underserved settings, (2) ensure that the strategy is informed by high-quality evidence from similar interventions in past outbreaks, and (3) evaluate and learn from research on interventions to garner data. Beyond the impact on health outcomes and healthcare services utilization, CoCoPOPP sought to garner data for organizational use and to share insights on pandemic management and control with the Ghanaian government and the broader global health community. Conclusion: The use of evidence-based public health framework, PARIHS, renders CoCoPOPP a replicable community-based model that can be implemented in other rural communities in Ghana and other Sub-Saharan African counties with similar cultural settings.