Fighting Carcinogenesis with Plant Metabolites by Weakening Proliferative
Signaling and Disabling Replicative Immortality Networks of Rapidly
Dividing and Invading Cancerous Cells

Wani, Atif Khurshid; Akhtar, Nahid; Sharma, Arun; El‐Zahaby, Sally A.

doi:10.2174/1567201819666220414085606

Cited by 10 publications

(2 citation statements)

References 174 publications

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“…Indigenous societies have long utilized plants for the treatment of diseases [12]. Plants act as useful anti-cancer agents, with more than 3000 plants evaluated for their role in fighting cancer by targeting apoptotic pathways [13][14][15]. In the last couple of decades, plants have been embraced as potent apoptotic inducers in cancer chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials

et al. 2023

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Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic proteins. Apoptosis maintains cellular balance within the human body through cell cycle progression. Loss of apoptosis control prolongs cancer cell survival and allows the accumulation of mutations that can promote angiogenesis, promote cell proliferation, disrupt differentiation, and increase invasiveness during tumor progression. The apoptotic pathway has been extensively studied as a potential drug target in cancer treatment. However, the off-target activities of drugs and negative implications have been a matter of concern over the years. Phytochemicals (PCs) have been studied for their efficacy in various cancer cell lines individually and synergistically. The development of nanoparticles (NPs) through green synthesis has added a new dimension to the advancement of plant-based nanomaterials for effective cancer treatment. This review provides a detailed insight into the fundamental molecular pathways of programmed cell death and highlights the role of PCs along with the existing drugs and plant-based NPs in treating cancer by targeting its programmed cell death (PCD) network.

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Section: Introductionmentioning

confidence: 99%

Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials

et al. 2023

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“…As mentioned above, these metabolites also have a wide range of biological activities (antioxidants, antimicrobials, anticancer agents, etc. ), making them highly valuable for human health and wellbeing, hence the use of plants in traditional medicine in many ancient communities [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Antioxidant Investigations of Extracts from the Leaves of Macaranga heterophylla (Müll. Arg.) (Euphorbiaceae), A Medicinal Species used in Côte d'Ivoire

N’cho,

N’gaman-Kouassi,

N’guessan

et al. 2024

Int. J. Biochem. Res. Rev.

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Aims: This work aims to investigate the phytochemical composition and antioxidant potential of the leaves of Macaranga heterophylla. Methodology: For this purpose, phytochemical screening by detection tests and thin layer chromatography (TLC), determination of total phenols content, total flavonoids content and condensed tannins content, and assessment of antioxidant potential by DPPH and reducing power tests were carried out on aqueous crude extracts, ethanolic crude extracts and selective extracts of the leaves of M. heterophylla. Results: The percentage yields obtained with ethanol (70%) (28.90 and 24.70% for the ethanolic decoction and ethanolic macerate respectively) are higher than those obtained with water (24.30 and 21.10% for the aqueous decoction and aqueous macerate respectively). The phytochemical screening highlighted the presence of several phytochemical families such as phenolic compounds (coumarins, flavones, tannins), quinones, sterols and polyterpenes, saponosides, glycosides, cardiotonic glycosides and oligosaccharides. Quantitative analysis of total phenolics, total flavonoids and proanthocyanidols showed that their respective levels in the leaves of M. heterophylla varied depending on the solvent and the extraction technique. Concerning total phenolics, the aqueous decoction and ethanolic macerate gave the best total phenol contents (129.04 ± 9.53 and 119.82 ± 2.63 mg EAG/g DM respectively); for total flavonoids, the aqueous decoction gave the best content (33.03 ± 1.61 mg EQ/g DM), while for condensed tannins, the aqueous macerate gave the best content (0.87 ± 0.02 mg ECT/g DM). With regard to DPPH antioxidant activity, the results showed that the ethanolic decoction has more pronounced antioxidant activity than the aqueous decoction, while the aqueous macerate showed better antioxidant activity than the ethanolic macerate. Concerning the reducing power test, the opposite trend was observed. Conclusion: The present study demonstrated that M. heterophylla is a concentrate of secondary metabolites with antioxidant properties, which would explain its use in traditional medicinal practice.

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Formulation and Characterization of RBCS Coated Carboplatin Loaded Nano‐Liposomal Formulation for Managing Breast Cancer

Dubey,

Raju,

Lobo

et al. 2024

Drug Development Research

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Cell membrane‐coated Nano‐Liposomes (CM‐NLPs) offer a promising approach that combines the advantages of both host cells and synthetic nano‐liposomes (NLPs). This technique involves coating liposomes with red blood cell (RBC) membranes to enhance their functionality. In this study, novel carboplatin‐loaded NLPs (CP‐NLPs) were formulated using phospholipids (Soya Phosphatidyl Choline) and cholesterol through the thin‐film hydration method, and optimized using a 32 full factorial design. The optimized CP‐NLPs were coated with RBC membranes, resulting in the formulation “CP‐RBCs‐NLPs.” These were characterized for particle size, zeta potential, entrapment efficiency, transmission electron microscopy (TEM), differential scanning calorimetry (DSC), protein content, in vitro drug release, cell viability, and stability. The optimized CP‐RBCs‐NLPs exhibited a particle size of 103.6 nm, with zeta potential values of −27.3 mV indicating good stability. The entrapment efficiency was approximately 56%, and the drug release profile showed sustained release for up to 8 h. Cytotoxicity studies in human triple‐negative breast cancer (MDA‐MB468) cell lines demonstrated that CP‐RBCs‐NLPs effectively delivered the drug into target cells, facilitating cell death due to their bilayer structure similar to cell membranes. Overall, CP‐RBCs‐NLPs outperformed both carboplatin‐loaded conventional NLPs (CP‐CNLPs) and carboplatin‐conventional solution (CP‐CNS), making it a superior formulation for drug delivery.

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Fighting Carcinogenesis with Plant Metabolites by Weakening Proliferative Signaling and Disabling Replicative Immortality Networks of Rapidly Dividing and Invading Cancerous Cells

Cited by 10 publications

References 174 publications

Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials

Targeting Apoptotic Pathway of Cancer Cells with Phytochemicals and Plant-Based Nanomaterials

Phytochemical and Antioxidant Investigations of Extracts from the Leaves of Macaranga heterophylla (Müll. Arg.) (Euphorbiaceae), A Medicinal Species used in Côte d'Ivoire

Formulation and Characterization of RBCS Coated Carboplatin Loaded Nano‐Liposomal Formulation for Managing Breast Cancer

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