Fighting metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux by mitochondria-targeting AIEgens

Su, Yan; Lin, Hai; Tu, Ying; Wang, Mengmeng; Zhang, Guandong; Yang, Jin Ming; Liu, Hong‐Ke; Su, Zhi

doi:10.1039/d1sc06722b

Cited by 22 publications

(14 citation statements)

References 59 publications

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“…The reaction was mediated by the 1-ethyl-3-(3-dimethylamino)propylcarbodiimide (EDC)/ N -hydroxysulfosuccinimide (NHSS) method, obtaining ChiP (Figure S3). The presence of the phenyl proton peaks in the 1 H NMR spectrum shows that PPh 3 was successfully grafted to the final polymers ChiP (Figure S4), which is consistent with previous studies of characterization. − …”

Section: Resultssupporting

confidence: 90%

Regulation of Bacterial Behavior by Light and Magnetism Mediated by Mesoporous Silica-Coated MnFe₂O₄@CoFe₂O₄ Nanoparticles

Deng

Lin

Zink

et al. 2022

ACS Appl. Mater. Interfaces

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Unicellular bacterial cells exhibit diverse population behaviors (i.e., aggregation, dispersion, directed assembly, biofilm formation, etc.) to facilitate communication and cooperation. Suitable bacterial behaviors are required for efficient nutrient uptake, cell recycling, and stress response for environmental and industrial application of bacterial populations. However, it remains a great challenge to artificially control bacterial behaviors because of complicated genetic and biochemical mechanisms. In this study, we designed facile mesoporous silica nanoparticle (MSN)-based assemblies to intelligently regulate bacterial behaviors with the help of light and magnetic field. This system was composed of magnetic MSNs, i.e., MnFe 2 O 4 @CoFe 2 O 4 @MSN modified by photoactive spiropyran (SP), and the chitosan-based polymers ChiPSP, i.e., chitosan grafted by triphenylphosphine and SP. The assembly strongly bound bacterial cells, inducing reversible bacterial aggregation by visible-light irradiation and dark. Moreover, the formed bacterial aggregates could be further governed by a directed magnetic field (DMF) to form microfibers and by an alternating magnetic field (AMF) to form biofilms. This study realized stimulus-triggered regulation of bacterial behaviors by MSNs and implied the great power of chemical strategies in intelligent control of diverse biological processes for environmental and industrial applications.

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Section: Resultssupporting

confidence: 90%

Regulation of Bacterial Behavior by Light and Magnetism Mediated by Mesoporous Silica-Coated MnFe₂O₄@CoFe₂O₄ Nanoparticles

Deng

Lin

Zink

et al. 2022

ACS Appl. Mater. Interfaces

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“…However, cancer cells can develop metal drug resistance after multiple rounds of treatment, greatly limiting the efficacy of treatment, which is no exception for lung cancer treatment [ 173 ]. To overcome cisplatin resistance, Su et al proposed a new strategy to solve the problem through mitochondrial dysfunction according to the anticancer mechanism of cisplatin (cis-Pt) [ 174 ]. Two mitochondria-targeted AIE molecules, DP-PPh 3 and TPE-PPh 3 , demonstrated superior ability to overcome cisplatin resistance in lung cancer cells (A549R) by altering drug metabolism (up-regulation of influx CTR1 and down-regulation of efflux MRP2) and blocking autophagy flux (failure of the degradation of autophagosomes).…”

Section: Aie-pss For Different Cancers Treatmentmentioning

confidence: 99%

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

et al. 2022

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Cancer remains a serious threat to human health owing to the lack of effective treatments. Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment that consists of three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone to aggregation-caused quenching (ACQ), leading to reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due to their distorted structure, suppress the strong molecular interactions, making them more photosensitive in the aggregated state instead. Activated by light, they can efficiently produce ROS and induce cell death. PS is one of the core factors of efficient PDT, so proceeding from the design and preparation of AIE-PSs, including how to manipulate the electron donor (D) and receptor (A) in the PSs configuration, introduce heavy atoms or metal complexes, design of Type I AIE-PSs, polymerization-enhanced photosensitization and nano-engineering approaches. Then, the preclinical experiments of AIE-PSs in treating different types of tumors, such as ovarian cancer, cervical cancer, lung cancer, breast cancer, and its great potential clinical applications are discussed. In addition, some perspectives on the further development of AIE-PSs are presented. This review hopes to stimulate the interest of researchers in different fields such as chemistry, materials science, biology, and medicine, and promote the clinical translation of AIE-PSs. Graphical Abstract

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“…The assembly of PTPE salts with different alkyl chain lengths and counter anions under different conditions was further explored [ 100 ], and the targetability and imaging ability of mitochondria are ascribed to AIE effects, which are promising for cancer therapy. In a recent study, Su et al developed AIEgens for the treatment of cis -platin-resistant cancer cells for the first time, which can induce ROS production and disrupt the mitochondrial structure, impairing mitochondrial and glycolytic metabolism [ 101 ]. Chemotherapeutic agents with AIE properties and anticancer activity offer a promising platform for integrating diagnosis and treatment.…”

Section: Aiegen-based Assembly For Theranostic Applicationsmentioning

confidence: 99%

Self-Assembly of Small Organic Molecules into Luminophores for Cancer Theranostic Applications

Wang

Yang

et al. 2022

Biosensors

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Self-assembled biomaterials have been widely explored for real-time fluorescence imaging, imaging-guided surgery, and targeted therapy for tumors, etc. In particular, small molecule-based self-assembly has been established as a reliable strategy for cancer theranostics due to the merits of small-sized molecules, multiple functions, and ease of synthesis and modification. In this review, we first briefly introduce the supramolecular chemistry of small organic molecules in cancer theranostics. Then, we summarize and discuss advanced small molecule-based self-assembly for cancer theranostics based on three types, including peptides, amphiphilic molecules, and aggregation-induced emission luminogens. Finally, we conclude with a perspective on future developments of small molecule-based self-assembled biomaterials integrating diagnosis and therapy for biomedical applications. These applications highlight the opportunities arising from the rational design of small organic molecules with self-assembly properties for precision medicine.

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Fighting metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux by mitochondria-targeting AIEgens

Abstract: PPh3-decorated mitochondrial-targeting AIEgens could fight metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux.

Cited by 22 publications

References 59 publications

Regulation of Bacterial Behavior by Light and Magnetism Mediated by Mesoporous Silica-Coated MnFe₂O₄@CoFe₂O₄ Nanoparticles

Regulation of Bacterial Behavior by Light and Magnetism Mediated by Mesoporous Silica-Coated MnFe₂O₄@CoFe₂O₄ Nanoparticles

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Self-Assembly of Small Organic Molecules into Luminophores for Cancer Theranostic Applications

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Fighting metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux by mitochondria-targeting AIEgens

Abstract: PPh3-decorated mitochondrial-targeting AIEgens could fight metallodrug resistance through alteration of drug metabolism and blockage of autophagic flux.

Cited by 22 publications

References 59 publications

Regulation of Bacterial Behavior by Light and Magnetism Mediated by Mesoporous Silica-Coated MnFe2O4@CoFe2O4 Nanoparticles

Regulation of Bacterial Behavior by Light and Magnetism Mediated by Mesoporous Silica-Coated MnFe2O4@CoFe2O4 Nanoparticles

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Self-Assembly of Small Organic Molecules into Luminophores for Cancer Theranostic Applications

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Product

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Regulation of Bacterial Behavior by Light and Magnetism Mediated by Mesoporous Silica-Coated MnFe₂O₄@CoFe₂O₄ Nanoparticles

Regulation of Bacterial Behavior by Light and Magnetism Mediated by Mesoporous Silica-Coated MnFe₂O₄@CoFe₂O₄ Nanoparticles