Fighting with obesity: the "gold standard" and new horizons

Drapkina, О. М.; Dubolazova, Y. V.; Boytsov, S. А.

doi:10.20996/1819-6446-2016-12-4-450-458

Cited by 7 publications

(1 citation statement)

References 19 publications

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“…Obesity Impact on the Cardiovascular System Влияние ожирения на структуру и функцию сердца декса массы тела (ИМТ), так и по величине окружности талии (ОТ) [3]. Распространенность абдоминального ожирения (АО), определяемого по величине окружности талии, в РФ составила 55% (61,8% среди женщин и 44% среди мужчин), тогда как доля лиц с ожирением, определяемым по ИМТ, значительно ниже (33,4%) [4].…”

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Obesity and Mechanisms of its Negative Impact on the Cardiovascular System

Miklishanskaya

Solomasova

Mazur

2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Currently, the number of obese people in the world is constantly increasing. Obesity has a direct negative impact on the heart and blood vessels, which can be considered not only as an appropriate response to an increase in the volume of circulating blood due to an increase in body weight, but also as a side tissue reaction of the myocardium to hormonal and metabolic changes inherent in obesity. Our review is devoted to the description of the mechanisms of influence of obesity on the structural and functional parameters of the heart, which create prerequisites for the development of cardiovascular diseases, as well as the existing contradictions. Currently, the accumulated data suggest that an excessive amount of adipose tissue, in addition to metabolic disorders, including insulin resistance, imbalance of adipokines and inflammation markers, leading to the development of lipotoxicity, can directly penetrate the myocardium and cause violations of its contractile properties, as well as affect the conduction of excitation pulses and provoke the development of rhythm and conduction disorders. The development of endothelial dysfunction in obesity ultimately leads to the development of atherosclerosis and coronary heart disease. In addition, obesity contributes to the emergence of risk factors for hypertension, diabetes, atrial fibrillation, chronic heart failure, obstructive sleep apnea syndrome. Given the differences in the literature on the effect of obesity on long-term outcomes in patients with cardiovascular diseases, it is important to conduct prospective studies on the role of individual factors and their combinations that affect the mortality of patients with cardiovascular diseases.

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Obesity and Mechanisms of its Negative Impact on the Cardiovascular System

Miklishanskaya

Solomasova

Mazur

2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Obesity treatment and adherence to doctors′ recommendations in patients with cardiovascular diseases and/or cardiovascular disease risk factors (results of patients’ interviews within the outpatient registry «PROFILE»)

et al. 2019

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Relationship of obesity, low-density lipoprotein cholesterol and myocardial perfusion in patients with risk factors and without atherosclerotic cardiovascular diseases

Сергиенко

Аншелес

Сергиенко

et al. 2021

Cardiovasc Ther Prev

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Aim. In the retrospective study, to identify the relationship between body mass index (BMI), low-density lipoprotein cholesterol (LDL-C) levels and myocardial perfusion in patients without established atherosclerotic cardiovascular diseases.Material and methods. The study included 534 patients with cardiovascular risk factors but without established coronary artery disease, diabetes, myocardial infarction or coronary revascularization. In 76 of them, stress/rest myocardial perfusion single-photon emission computed tomography (SPECT) was performed.Results. The relationship between BMI and LDL-C levels is described by a quadratic (r2=0,21, p<0,001) function or a linear spline kinked in BMI of 27 kg/m2 (r=0,51, -0,46 — before and after this value, respectively; p<0,001). According to SPECT, focal stable and transient left ventricular myocardial perfusion abnormalities were not detected. However, there was a direct linear correlation between the heterogeneity of rest myocardial perfusion (ohet) and BMI (r=0,43, p<0,001), ohet and waist circumference (r=0,40, p<0,001), as well as between ohet and LDL-C (r=0,44, p<0,001).Conclusion. The relationship between BMI and LDL-C levels can be explained by endocrine dysfunction of adipose tissue, which disturbs the synthesis and metabolism of atherogenic lipoproteins. Obesity and increased LDL-C levels affect myocardial perfusion both by aggravating coronary atherogenesis and by microcirculatory disorders. Rest myocardial perfusion SPECT can be a method of screening for myocardial disorders caused by both diffuse atherosclerosis and metabolic syndrome.

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Fighting with obesity: the "gold standard" and new horizons

Cited by 7 publications

References 19 publications

Obesity and Mechanisms of its Negative Impact on the Cardiovascular System

Obesity and Mechanisms of its Negative Impact on the Cardiovascular System

Obesity treatment and adherence to doctors′ recommendations in patients with cardiovascular diseases and/or cardiovascular disease risk factors (results of patients’ interviews within the outpatient registry «PROFILE»)

Relationship of obesity, low-density lipoprotein cholesterol and myocardial perfusion in patients with risk factors and without atherosclerotic cardiovascular diseases

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