FIGO (International Federation of Gynecology and Obstetrics) initiative on fetal growth: Best practice advice for screening, diagnosis, and management of fetal growth restriction

Melamed, Nir; Baschat, Ahmet; Yinon, Yoav; Athanasiadis, Apostolos; Mecacci, Federico; Figueras, F.; Berghella, Vincenzo; Nazareth, Amala; Tahlak, Muna; McIntyre, H. David; Costa, Fabrício da Silva; Kihara, Anne Beatrice; Hadar, Eran; McAuliffe, Fionnuala M.; Hanson, Mark A.; Ronald, C.; Gooden, Rachel; Sheiner, Eyal; Kapur, Anil; Divakar, Hema; Ayres‐de‐Campos, Diogo; Hiersch, Liran; Poon, Liona C.; Kingdom, John; Romero, Roberto; Hod, Moshe

doi:10.1002/ijgo.13522

Cited by 283 publications

(289 citation statements)

References 468 publications

(871 reference statements)

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“…Early identification of SGA aims to reduce the risk of stillbirth and neonatal mortality and morbidity associated with this condition [29]. The use of sFlt-1 measured at 19 to 24 weeks as a biomarker for SGA is restricted by its low deviation in smaller babies and the temporal changes until 32 weeks' gestation.…”

Section: Discussionmentioning

confidence: 99%

Competing Risks Model for Prediction of Small for Gestational Age Neonates and the Role of Second Trimester Soluble Fms-like Tyrosine Kinase-1

Nowacka

Papastefanou

Bouariu

et al. 2021

JCM

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Small for gestational age (SGA) fetuses/neonates are characterized by the increased risk for adverse outcomes that can be reduced if the condition is identified antenatally. We have recently developed a new approach in SGA prediction that considers SGA a spectrum condition that is reflected in two dimensions: gestational age at delivery and Z score in birth weight for gestational age. The new method has a better predictive ability than the traditionally used risk-scoring systems and logistic regression models. In this prospective study in 40241 singleton pregnancies, at 19–24 weeks’ gestation, we examined the potential value of the antiangiogenic soluble fms-like tyrosine kinase-1 (sFlt-1) and the ratio of sFlt-1 to the angiogenic placental growth factor (PlGF) in the prediction of SGA. We found that first, sFlt-1 did not improve the performance of screening by maternal risk factors, and second, the ratio of sFlt-1/PlGF had a worse performance than PlGF alone in the prediction of SGA. Consequently, second trimester sFlt-1 and sFlt-1/PlGF are not useful in screening for SGA.

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Section: Discussionmentioning

confidence: 99%

Competing Risks Model for Prediction of Small for Gestational Age Neonates and the Role of Second Trimester Soluble Fms-like Tyrosine Kinase-1

Nowacka

Papastefanou

Bouariu

et al. 2021

JCM

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“…Intrauterine growth restriction (IUGR) occurs when the fetus does not grow as expected according to its gestational age. IUGR encompasses fetal growth restriction (FGR) and small for gestational age (SGA) [144]. While SGA fetuses are constitutionally small, FGR is diagnosed when a fetus' weight lies below the 10th percentile for its gestational age (GA) as a result of a pathological factor, and it is a very important cause of perinatal mortality and morbidity [144,145].…”

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

“…IUGR encompasses fetal growth restriction (FGR) and small for gestational age (SGA) [144]. While SGA fetuses are constitutionally small, FGR is diagnosed when a fetus' weight lies below the 10th percentile for its gestational age (GA) as a result of a pathological factor, and it is a very important cause of perinatal mortality and morbidity [144,145]. Maternal and placental factors, along with genetics, contribute to fetal growth.…”

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

Maternal HPV Infection: Effects on Pregnancy Outcome

Condrat

Filip

Gherghe

et al. 2021

Viruses

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The human papilloma virus (HPV) infection, caused by a ubiquitous virus typically transmitted through the direct contact of infected organs, either through the skin or mucosa, is the most common sexually transmitted infection, placing young women at a high risk of contracting it. Although the vast majority of cases spontaneously clear within 1–2 years, persistent HPV infection remains a serious concern, as it has repeatedly been linked to the development of multiple malignancies, including cervical, anogenital, and oropharyngeal cancers. Additionally, more recent data suggest a harmful effect of HPV infection on pregnancy. As the maternal hormonal environment and immune system undergo significant changes during pregnancy, the persistence of HPV is arguably favored. Various studies have reported an increased risk of adverse pregnancy outcomes among HPV-positive women, with the clinical impact encompassing a range of conditions, including preterm birth, miscarriage, pregnancy-induced hypertensive disorders (PIHD), intrauterine growth restriction (IUGR), low birth weight, the premature rupture of membranes (PROM), and fetal death. Therefore, understanding the mechanisms employed by HPV that negatively impact pregnancy and assessing potential approaches to counteract them would be of interest in the quest to optimize pregnancy outcomes and improve child survival and health.

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“…While multiple methods are available to monitor the fetuses of hypertensive pregnancies, no strategy of various methods and timings has been recognized to be superior in this group or in general. As the fetus with growth restriction and/or reduced liquor volume is at particular risk of stillbirth and neonatal mortality and morbidity, ultrasonographic assessment of fetal growth and liquor volume is recommended 43,44 . Trials suggest that in high‐risk pregnancies, Doppler ultrasound of the umbilical artery may reduce perinatal death and obstetric intervention, but the evidence is not definitive 45 ; it is important to note that near or at term, a normal umbilical artery Doppler does not exclude fetal compromise 46–48 .…”

Section: Blood Pressure Delivery and Postpartum Managementmentioning

confidence: 99%

A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre‐eclampsia

Poon

Magee

Verlohren

et al. 2021

Intl J Gynecology & Obste

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FIGO (International Federation of Gynecology and Obstetrics) initiative on fetal growth: Best practice advice for screening, diagnosis, and management of fetal growth restriction

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 283 publications

References 468 publications

Competing Risks Model for Prediction of Small for Gestational Age Neonates and the Role of Second Trimester Soluble Fms-like Tyrosine Kinase-1

Competing Risks Model for Prediction of Small for Gestational Age Neonates and the Role of Second Trimester Soluble Fms-like Tyrosine Kinase-1

Maternal HPV Infection: Effects on Pregnancy Outcome

A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre‐eclampsia

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