FIGO stage IV gestational choriocarcinoma misdiagnosed as pulmonary tuberculosis: A case report

Yang, Lianjun; Xu, Peng; Xi, Mingrong; Wang, Hongjing

doi:10.3892/ol.2015.3443

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Around 75% of choriocarcinoma even at stage FIGO IV will achieve complete or prolonged remission. 11 In this case if accurate and early prompt diagnosis could have been made then the number of chemotherapy doses have been less and anti-tubercular drugs would be avoided.…”

Section: Discussionmentioning

confidence: 99%

Importance of Suspecting a Hemorrhagic Intracranial Lesion as Metastatic Choriocarcinoma

et al. 2022

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Though the brain metastasis from gestational trophoblastic neoplasia is rare, incidence is 3-21.4%. In this article, we report the rare case of a young female, presented with the features of raised Intracranial Pressure (ICP) with intracranial space occupying lesion, who was treated for tubercular abscess because she was clinically diagnosed as case of pulmonary TB from core biopsy of lung mass and was under Anti tubercular treatment at other center and the differential diagnosis of cavernoma bleed made from imaging modalities. However, to our surprise the histopathology came out as metastatic choriocarcinoma. There was history of incomplete abortion 1 year back which could have developed from any gestational trophoblastic tissue resulting from a hydatidiform mole, miscarriage, or ectopic pregnancy. She gave this history after the histopathology came out as metastatic choriocarcinoma. The social tabu and going through traumatic experience, would be the region for her not to disclose the history before surgery. Although miscarriages are common and women continue to suffer in silence. The rarity of brain metastasis from gestational trophoblastic neoplasia, there are still no guidelines on treatment strategies for these patients yet.

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Section: Discussionmentioning

confidence: 99%

Importance of Suspecting a Hemorrhagic Intracranial Lesion as Metastatic Choriocarcinoma

et al. 2022

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“…Yang et al [2] reported a case of gestational choriocarcinoma misdiagnosed as pulmonary tuberculosis in a patient who had no abnormal uterine bleeding. When a patient presents with multiple pulmonary nodules, brain multiple mass, or other viscera multiple mass, we must consider choriocarcinoma, whether the patient is pregnant or not, whether or not menstruation has ceased, and whether or not there is irregular vaginal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Choriocarcinoma brain metastasis in a patient in the third trimester: a case report

Shen

et al. 2021

J Med Case Reports

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Background Metastatic choriocarcinoma in the third trimester of pregnancy is extremely rare. Case presentation A 25-year-old Chinese woman (gravida 3, para 0) who was 28 weeks pregnant was admitted for sudden convulsion, aconuresis, and unconsciousness. The decision was made to perform an emergency cesarean delivery and craniotomy, hematoma clearance, and decompression. Pathological examination confirmed choriocarcinoma with brain metastasis. The patient underwent chemotherapy with the etoposide, cisplatin (EP) and etoposide, methotrexate and dactinomycin alternating with cyclophosphamide and vincristine (EMACO) regimens. A satisfactory result was achieved. Conclusions When encountering intracranial mass or bilateral pulmonary nodules in a pregnant woman, especially one in the third trimester, metastatic choriocarcinoma should be considered.

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“…Choriocarcinomas spread hematogenously to the lungs, resulting in PE, pulmonary hypertension, or acute respiratory distress syndrome. Although the prognosis for metastatic gestational choriocarcinoma to the lungs (stage III) is good, the rarity of a PE can result in a misdiagnosis, and the patient might be treated for more common diseases, such as pneumonia and tuberculosis [ 1 , 2 ]. In the present case, the patient also was diagnosed incorrectly with tuberculosis and a venous pulmonary thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Pulmonary Tumor Embolism from Choriocarcinoma: Extracorporeal Membrane Oxygenation as a Bridge through Chemotherapy

et al. 2017

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A 22-year-old woman with a 1-month history of shortness of breath that was treated as a case of tuberculosis and pulmonary embolism was referred to the authors’ hospital. Because of the hemodynamic instability in this patient, venoarterial extracorporeal membrane oxygenation (ECMO) was administered in the intensive care unit. She underwent a pulmonary embolectomy for the treatment of progressive circulatory collapse secondary to a pulmonary embolism. The histopathologic result was consistent with a metastatic choriocarcinoma. Despite the surgical management, persistent refractory cardiogenic shock occurred. Subsequently, the patient was treated with chemotherapy in the presence of ECMO and responded well to chemotherapy. She was discharged after 3 months. This case suggests that metastatic choriocarcinoma should be considered as a differential diagnosis in women of childbearing age presenting with a pulmonary embolism, and ECMO may be beneficial in patients with pulmonary embolism for bridging to surgical embolectomy and chemotherapy.

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FIGO stage IV gestational choriocarcinoma misdiagnosed as pulmonary tuberculosis: A case report

Cited by 5 publications

References 18 publications

Importance of Suspecting a Hemorrhagic Intracranial Lesion as Metastatic Choriocarcinoma

Importance of Suspecting a Hemorrhagic Intracranial Lesion as Metastatic Choriocarcinoma

Choriocarcinoma brain metastasis in a patient in the third trimester: a case report

Treatment of Pulmonary Tumor Embolism from Choriocarcinoma: Extracorporeal Membrane Oxygenation as a Bridge through Chemotherapy

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