Figure 1 from: Angelina M, Mardhiyah A, Dewi RT, Fajriah S, Muthiah N, Ekapratiwi Y, Dewijanti ID, Sukirno, Jamilah, Hartati S (2021) Physicochemical and phytochemical standardization, and antibacterial evaluation of Cassia alata leaves from different locations in Indonesia. Pharmacia 68(4): 947-956. https://doi.org/10.3897/pharmacia.68.e76835

Angelina, Marissa; Mardhiyah, Ainul; Dewi, Rizna Triana; Fajriah, Sofa; Muthiah, Nusaibah; Ekapratiwi, Yasmin; Dewijanti, Indah Dwiatmi; Sukirno, Sukirno; Jamilah, Jamilah; Hartati, Sri

doi:10.3897/pharmacia.68.e76835.figure1

2021

DOI: 10.3897/pharmacia.68.e76835.figure1

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Figure 1 from: Angelina M, Mardhiyah A, Dewi RT, Fajriah S, Muthiah N, Ekapratiwi Y, Dewijanti ID, Sukirno, Jamilah, Hartati S (2021) Physicochemical and phytochemical standardization, and antibacterial evaluation of Cassia alata leaves from different locations in Indonesia. Pharmacia 68(4): 947-956. https://doi.org/10.3897/pharmacia.68.e76835

Marissa Angelina¹,

Ainul Mardhiyah²,

Rizna Triana Dewi³

et al.

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Formulation and Antibacterial Activity Test of Cream containing Cassia alata Leaves Extract against Propionibacterium acnes and Staphylococcus epidermidis

2024

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Propionibacterium acnes and Staphylococcus epidermidis are Gram-positive commensal bacteria on human skin that can turn opportunistic. In a previous study, Cassia alata L. leaves extract had shown antibacterial activity against Gram-positive bacteria. In this study, C. alata leaves extract is used as an active ingredient in a topical cream preparation. This study aimed to determine the stability and the antibacterial activity of C. alata leaves extract cream against P. acnes and S. epidermidis. We prepared topical cream containing 1.25%, 2.5%, and 5% of C. alata extract and evaluated their physical parameters. The prepared C. alata leaves extract cream had good physical characteristics, but there were underwent changes during the accelerated stability test. The antibacterial activity of the C. alata leaves extract cream was studied using the agar well diffusion method. The results showed that the variations of C. alata leaves extract affected the antibacterial activity against P. acnes and S. epidermidis. Cream containing 5% ethanolic extract of C. alata leaves had the highest antibacterial activity.

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Formulation and Antibacterial Activity Test of Cream containing Cassia alata Leaves Extract against Propionibacterium acnes and Staphylococcus epidermidis

2024

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Antioxidant activity of Yellow Candle bush (Cassia alata) leaves extract and Bioactive fractions through LC-QTOF-MS/MS and Molecular Docking Approach

Megawati,

Ernawati,

Angelina

et al. 2024

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Free radicals play a significant role in numerous cellular functions, such as cell signaling, metabolism, and defense mechanism. Cassia alata, well known as Yellow Candle bush or locally known as Ketepeng Badak, has been known to possess biological activities including antiinflamation and antidiabetic. This current study investigates the antioxidant potential of C. alata leaves crude extract and resultant fractions. DPPH, ABTS radical scavenging activity, and FRAP assay were evaluated for the determination of the antioxidant activity, while the active constituents in C. alata leaf extract and fractions were identified with LC-QTOF-MS/MS. Total phenolic, flavonoid, and DPPH radical scavenging activities were highest in the ethyl acetate fraction with IC50: 18.54±0.01µg/mL on DPPH assay. Meanwhile, butanol fraction exhibited the strongest activity in ABTS and FRAP tests with IC50 of 4.29±0.26µg/mL and 4.39±0.11µg/mL, respectively. An in silico study using a molecular docking technique was conducted to determine the free energy of binding between human heme oxygenase-1 (HO-1) with bioactive compounds contained in C. alataethanolic leaves extract. Molecular docking of the main constituents in C. alata ethyl acetate fraction showed a greater binding affinity for kaempferol-3-O-β-D-glucopyranoside (-8.95kcal/mol), followed by coclaurine (-7.94kcal/mol), quercetin (-7.66kcal/mol) and 3-Hydroxy-7-methoxy baicalein (-7.32kcal/mol). These results corroborate the potent antioxidant activity of C. alata extract and fractions and its use as possible antioxidant agents in the pharmaceutical industry.

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Cited by 2 publications

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Formulation and Antibacterial Activity Test of Cream containing Cassia alata Leaves Extract against Propionibacterium acnes and Staphylococcus epidermidis

Formulation and Antibacterial Activity Test of Cream containing Cassia alata Leaves Extract against Propionibacterium acnes and Staphylococcus epidermidis

Antioxidant activity of Yellow Candle bush (Cassia alata) leaves extract and Bioactive fractions through LC-QTOF-MS/MS and Molecular Docking Approach

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