Figure 2 from Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways

Abstract

<p><b>A,</b> Phylogenies inferred for the 14 patients. Only WES samples are included. Letters in brackets indicate melanoma subtype: A = acral, C = cutaneous, M = mucosal, U = melanoma of unknown primary. Branch length is proportional to the number of mutations. Branch colors represent the mutational signatures of the mutations. For clarity, only the most common mutational signatures are shown; the remainder are categorized as “unknown.” Scale bars indicate the number of mutations. The legend includes etiologies for each signature (<a href="#bib24" target="_blank">24</a>). MMR, mismatch repair. <b>B,</b> Boxplots indicate the ratio of subclonal mutations (length of branches) to clonal mutations (length of the trunk) by subtype and chemotherapy status. Values smaller than zero indicate the dominance of truncal mutations. Mann–Whitney <i>U</i> test was used for statistical comparisons (**, <i>P</i> < 0.01; ***, <i>P</i> < 0.001). Cut., cutaneous; mut., mutation.</p>