Antimicrobial Drug Discovery: Emerging Strategies 2012
DOI: 10.1079/9781845939434.0135
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Filamentous temperature-sensitive mutant Z (FtsZ) protein as an antibacterial target.

Abstract: This chapter reviews current knowledge on the structure, biochemistry and function of the FtsZ protein in bacterial pathogens, highlighting its potential as a promising drug target for the development of novel antibacterial agents. Strategies that can be utilized for the identification of potential Ftsz inhibitors are discussed.

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Cited by 2 publications
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“…The gene of FtsZ has the ability of high conservation and presented almost in all bacteria 9,36 . In bacterial cytokinesis, FtsZ protein is the earliest known step to build a contractile ring on the inner surface of the cytoplasmic membrane 9,36 . The inhibitors of FtsZ might prevent the cellular fission of bacteria, which lead to apoptosis of bacteria.…”
Section: Discussionmentioning
confidence: 99%
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“…The gene of FtsZ has the ability of high conservation and presented almost in all bacteria 9,36 . In bacterial cytokinesis, FtsZ protein is the earliest known step to build a contractile ring on the inner surface of the cytoplasmic membrane 9,36 . The inhibitors of FtsZ might prevent the cellular fission of bacteria, which lead to apoptosis of bacteria.…”
Section: Discussionmentioning
confidence: 99%
“…7 showed, the coccoid cells of S. aureus were swollen to 1.4 to 1.7-fold volume after treatment with compound 1 (1.4 fold), 2 (1.7 fold) and 5 (1.6 fold), respectively. In order to explain this interesting appearance, FtsZ, the key protein of cell division 8,9 , was explored to illustrate the mechanism of cells that became swollen. Thus, a molecular docking study was carried out to verify the deduction.…”
Section: Discussionmentioning
confidence: 99%
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“…It is present in almost all species of bacteria and is the ancestor of the eukaryotic tubulin. The three-dimensional structures of both proteins are remarkably similar despite low-level (10–18%) amino acid similarity [13]. Recent evidence that the plant antimicrobial berberine can also target FtsZ in the nematode Onchocerca volvulus is also intriguing [14].…”
Section: Advances In Bioactivity-guided Discoverymentioning
confidence: 99%