Filaricidal Activity of Phytochemicals Against Lymphatic Filariasis

Hanchinalmath, Jayashree V.; D'mello, Darcia; Shivasharanappa, Kirankumar; Pramod, Toshniwal; Patil, Sharangouda J.

doi:10.1002/9781119617143.ch9

Cited by 1 publication

(1 citation statement)

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“…Filariasis of animals, especially mammals, can be transmitted to humans and is often characterised by the absence of specific symptoms [ 6 , 7 ]. Human infections with zoonotic filariasis are reported worldwide [ 8 ] and were first described in modern research over a century ago [ 9 ]. A number of different genera of filaria have been isolated from humans, including Dirofilaria [ 10 , 11 ], Brugia [ 12 , 13 ], Onchocerca [ 14 , 15 ], Dipetalonema [ 16 , 17 ], Loa [ 18 , 19 ], and Mansonella [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Beyond Tradition: Exploring Cutting-Edge Approaches for Accurate Diagnosis of Human Filariasis

Pietrzak,

Łuczak,

Wiśniewski

2024

Pathogens

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Filariasis is recognised as a global public health threat, particularly in tropical and subtropical regions. It is caused by infection with a nematode parasite of the superfamily Filarioidea, including Wuchereria bancrofti, Brugia malayi, Onchocerca volvulus, and Onchocerca lupi. Three main types of filariasis have been classified: lymphatic filariasis, subcutaneous filariasis, and serous cavity filariasis. The symptoms exhibited by individuals afflicted with filariasis are diverse and contingent upon several variables, including the species of parasite, the host’s health and immune response, and the stage of infection. While many classical parasitological techniques are considered indispensable tools for the diagnosis of parasitic infections in humans, alternative methods are being sought due to their limitations. Novel tests based on host–parasite interactions offer a rapid, simple, sensitive, and specific diagnostic tool in comparison to traditional parasitological methods. This article presents methods developed in the 21st century for the diagnosis of filariasis caused by invasion from W. bancrofti, B. malayi, O. volvulus, and O. lupi, as well as techniques that are currently in use. The development of modern diagnostic methods based on molecular biology constitutes a significant advancement in the fight against filariasis.

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