Film-Forming Systems for the Delivery of DNDI-0690 to Treat Cutaneous Leishmaniasis

Bocxlaer, Katrien Van; McArthur, Kerri-Nicola; Harris, Andy; Alavijeh, Mohammad S.; Braillard, Stéphanie; Mowbray, Charles E.; Croft, Simon L.

doi:10.3390/pharmaceutics13040516

Cited by 16 publications

(11 citation statements)

References 33 publications

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“…One of them, Strat-M synthetic membranes, as depicted schematically in Figure 20. This type of assay is performed as a membrane passage experiment with a Franz diffusion cell method [368,369]. Fick's laws of diffusion describe the transdermal permeation [366,367,370] by relating flow and apparent permeability.…”

Section: Formulation Of a Functionalized Nanoemulsion For The Adminis...mentioning

confidence: 99%

“…Recently, this approach was used to formulate and deploy a promising Leishmaniasis treatment with a nanoemulsion-based cream, tailored to be applied on the skin [371]. [364,368,370].…”

Section: Formulation Of a Functionalized Nanoemulsion For The Adminis...mentioning

confidence: 99%

“…Figure 20. Schematical representation of the transdermal delivery through human skin and Strat-MTM membrane[364,368,370].…”

mentioning

confidence: 99%

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Formulation in Surfactant Systems: From-Winsor-to-HLDN

Salager¹,

Márquez²,

Bullón³

et al. 2022

Preprint

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Formulation is an ancient concept, although the word has been used only recently. The first formulations made our civilization advance by inventing bronze, steel, and gunpowder; then, it was used in medieval alchemy. When chemistry became a science and with the golden age of organic synthesis, the second formulation period began. This made it possible to create new chemical species and new combinations “à la carte.” However, the research and developments were still carried out by trial and error. Finally, the third period of formulation history began after World War II, when the properties of a system were associated with its ingredients and the way they were assembled or combined. Therefore, the formulation and the systems’ phenomenology were related to the generation of some synergy to obtain a commercial product. Winsor’s formulation studies in the 1950s were enlightening for academy and industries that were studying empirically surfactant-oil-water (SOW) systems. One of its key characteristics was how the interfacial interaction of the adsorbed surfactant with oil and water phases could be equal by varying the physicochemical formulation of the system. Then, Hansen’s solubility parameter in the 1960s helped to reach a further understanding of the affinity of some substances to make them suitable to oil and water phases. In the 1970s, researchers such as Shinoda and Kunieda, and different groups working in Enhanced Oil Recovery (EOR), among them Schechter and Wade’s group at the University of Texas, made formulation become a science by using semiquantitative correlations to attain specific characteristics in a system (e.g., low oil-water interfacial tension, formulation of a stable O/W or W/O emulsion, or high-performance solubilization in a bicontinuous microemulsion system at the so-called optimum formulation). Nowadays, over 40 years of studies with the hydrophilic-lipophilic deviation equation (HLD) have made it feasible for formulators to improve products in many different applications using surfactants to attain a target system using HLD in its original or its normalized form, i.e., HLDN. Thus, it can be said that there is still current progress being made towards an interdisciplinary applied science with numerical guidelines. In the present work, the state-of-the-art of formulation in multiphase systems containing two immiscible phases like oil and water, and therefore systems with heterogeneous or micro-heterogeneous interfaces, is discussed. Surfactants, from simple to complex or polymeric, are generally present in such systems to solve a wide variety of problems in many areas. Some significant cases are presented here as examples dealing with petroleum, foods, pharmaceutics, cosmetics, detergency, and other products occurring as dispersions, emulsions, or foams, that we find in our everyday lives.

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Section: Formulation Of a Functionalized Nanoemulsion For The Adminis...mentioning

confidence: 99%

“…Recently, this approach was used to formulate and deploy a promising Leishmaniasis treatment with a nanoemulsion-based cream, tailored to be applied on the skin [371]. [364,368,370].…”

Section: Formulation Of a Functionalized Nanoemulsion For The Adminis...mentioning

confidence: 99%

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Formulation in Surfactant Systems: From-Winsor-to-HLDN

Salager¹,

Márquez²,

Bullón³

et al. 2022

Preprint

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“…The treating scheme mentioned above is associated with a traumatic effect due to the type of administration and the location of the injury to infiltrate, as is the case of genital and face injuries, especially with small children [9,39]. These conditions promote treatment dropout, especially in regions of difficult access.…”

Section: Of 16mentioning

confidence: 99%

“…Figure 2 shows a Franz cell, which consists of an upper compartment (giver) where the sample under study was placed (vehicle with the active ingredient). Moreover, an inferior compartment (reception) was placed within a liquid, which, in this case, was a saline buffer solution at pH = 7.4, very similar to the mammal's extracellular liquid [39,78]. A membrane, which in this case was the Strat-M membrane, was placed between both compartments.…”

Section: Cream Stability Testsmentioning

confidence: 99%

A Promising Cutaneous Leishmaniasis Treatment with a Nanoemulsion-Based Cream with a Generic Pentavalent Antimony (Ulamina) as the Active Ingredient

et al. 2021

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Leishmania parasites are the etiological agents of Leishmaniasis, a tropical disease that affects around 15 million people in about 90 countries. The chosen therapy for this disease is based on antimony V compounds, such as meglumine antimoniate. It can be administered as a parenteral, subcutaneous or perilesional form as successive infiltrations with pre-established doses localized in the border of the granuloma that characterizes the wound of Cutaneous Leishmaniasis (CL). Herein, a topical pharmaceutical recipe, such as an emulsion, is proposed to eliminate the trauma caused by administering the medicine in parenteral form to the face or other difficult access zones. The evaluation of this vehicle was performed by analyzing parameters such as pH, viscosity, homogeneity and droplet size distribution. Furthermore, the effectiveness of the emulsion was proved by in vitro experiments using Strat-M synthetic membranes, showing that the transdermal passage of the antimonial complex is guaranteed. Moreover, complete healing of the wound has been attained in patients with CL, as shown with two clinical cases in this article.

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